Drug & supplement interaction

Prohormones + Opicapone

Opicapone brand name: Ongentys.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Prohormones and Opicapone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Prohormones and Opicapone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Opicapone and Prohormones in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Prohormones at all — not against Opicapone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Prohormones safety at a glance

Prohormones overall Avoid These hormone-altering compounds carry serious health risks and are best avoided without medical supervision.
Pregnancy Avoid Hormonal effects can harm a developing baby; do not use during pregnancy.
Breastfeeding Possibly Unsafe When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Opicapone and Prohormones? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Opicapone’s Own FDA Label Lists

This is not an interaction — none of it involves Prohormones. These are the most notable effects listed in the ADVERSE REACTIONS section of Opicapone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 13.9% of FDA reports for Opicapone
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Raised blood pressure Worth acting on
  • Weight gain
  • Weight loss
  • Dry mouth
  • Low blood pressure
  • Drowsiness
  • Trouble sleeping

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Opicapone. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,261 voluntary FDA FAERS reports for Opicapone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Prohormones’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Prohormones side to compare — that is a limit of the record, not a statement that Prohormones has no side effects.

Special populations

Prohormones in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Opicapone

This page covers Prohormones only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Opicapone page lists 58 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Ayahuasca (moderate), Bitter Melon (moderate) and Black Horehound (moderate).

By severity: 2 major · 39 moderate · 17 minor.

From our pharmacist’s overview on the Opicapone page

“If you take opicapone (Ongentys) alongside levodopa for Parkinson's disease, don't skim this page. Two entries can genuinely undercut your treatment: St.”

Reviewed by 2 · Jul 18, 2026

Open the Opicapone interaction page

How much people look this up

Where Prohormones and Opicapone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Prohormones
Top half

#715 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Opicapone
Top half

#943 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Prohormones reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Prohormones and Opicapone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Prohormones

What is Prohormones?

  • Muscle building
  • Strength and athletic performance
  • Body recomposition
  • Fat loss
  • Bodybuilding cycles

Prohormones are steroid-like compounds the body can convert into active anabolic hormones such as testosterone. They are marketed for muscle and strength gains, but they carry real risks to the liver, heart, and hormone balance, and many sold as supplements are legally and chemically questionable. We do not recommend them outside of medical supervision, and they should never be used during pregnancy or breastfeeding.

Synthetic or semi-synthetic steroidal compounds (not a plant part) · Capsules, tablets, powders

An interaction check asks whether these two react with each other — it does not ask whether Prohormones is a good idea for someone in your situation. Here is what our Prohormones record says about it on its own.

Prohormones: dosing

There is no established safe or standardized dose for prohormones, and we cannot recommend one. Products vary widely in their ingredients and strength, and labels are not always accurate.Because these compounds act like hormones and carry real risks, the safest approach is to avoid them unless you are under the care of a qualified medical provider.

From our Prohormones monograph — the full record covers uses, side effects and every documented interaction.

Read the full Prohormones monograph & all interactions
Medication

About Opicapone

What Is Opicapone Used For?

Brand name: Ongentys

Ongentys (opicapone) is used alongside levodopa/carbidopa to treat Parkinson's disease in adults who experience 'off' episodes — periods when medication wears off and Parkinson's symptoms return before the next dose is due.

It is not used alone. Ongentys works as an add-on to help levodopa stay active longer, reducing the time patients spend in these 'off' states.

Most-Reported Side Effects for Opicapone

From FAERS, the FDA’s public side-effect reporting system (2,261 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 314 reports
Dyskinesia 306 reports
Fall 258 reports
On and off phenomenon 158 reports
Tremor 143 reports
See full Opicapone drug information
Keep checking

Other Drugs & Prohormones

Browse every other medication we’ve checked against Prohormones — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Prohormones against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Prohormones list.

See the full Prohormones interactions page
See every supplement checked against Opicapone, ranked by severity
Evidence & sources

Prohormones References

The 1 references that drive our Prohormones monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Prohormones and Opicapone Together: Common Questions

Is it safe to take Prohormones with Opicapone?
We do not list a known interaction between Prohormones and Opicapone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Opicapone interact with any supplements?
Yes. Opicapone has documented interactions with 58 supplements in our database — Prohormones is not one of them. The Opicapone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Prohormones monograph Uses, safety profile, and every drug interaction in one place Opicapone drug information The full plain-English guide to this medication Opicapone supplement interactions Every supplement checked against Opicapone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Opicapone and Prohormones?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.