Propolis + Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.
Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 drug categories that Propolis can interact with; the most serious is rated moderate. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full interaction reportPropolis and Diphenhydramine Hydrochloride, Naproxen Sodium
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Propolis interacts with whole categories of medication. Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 of those categories, so it can interact with Propolis in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Propolis interacts with.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM combines naproxen (a pain reliever) with diphenhydramine (the sleepy antihistamine found in Benadryl). The theory here is that propolis might block an enzyme called CYP1A2, which helps clear certain medicines. If that enzyme slowed down, a drug like this could linger a bit longer, which in plain terms might mean more drowsiness, grogginess, dry mouth, or stomach upset.
Here's the reassuring part: this concern comes only from lab dish studies. When propolis was actually tested in animals, it did not meaningfully affect this enzyme, and there are no reports of problems in people. Neither of these drugs is a prodrug, so nothing flips. Food-level amounts are very unlikely to matter, but if you take concentrated propolis supplements daily, just mention it to your pharmacist.
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
2 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM combines naproxen (a pain and inflammation reliever) with diphenhydramine (a sedating antihistamine for sleep). The naproxen part is partly cleared by a liver enzyme called CYP2C9. In the test tube, propolis can slow that enzyme down, which in theory could let naproxen build up a bit and lead to stronger effects like stomach upset, heartburn, or a higher risk of stomach irritation.
The good news: this is only a theoretical concern. Animal studies didn't show a real effect, and it has never been reported in people. It would mostly matter, if at all, with concentrated, high-dose propolis supplements rather than small amounts. Still, if you take both regularly, it's worth a quick chat with your pharmacist or doctor.
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
3 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the connection with Aleve PM. The naproxen part of this combo is an NSAID, and NSAIDs already nudge up bleeding risk a little by affecting how your platelets stick together. Propolis, in lab studies, seems to do something similar, slowing platelet clumping. So in theory, taking both could add up to a slightly higher chance of bruising, nosebleeds, or stomach irritation and bleeding.
I want to be honest about how soft this evidence is. It comes from test tube and animal research, not human studies, so we really don't know how much it matters in real life. The diphenhydramine (the PM sleep aid) isn't the concern here. If you take Aleve PM regularly, or you're also on a blood thinner, just run the propolis past your pharmacist or doctor first.
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Propolis Also Interacts With Other Medications
Propolis has 920 moderate known drug interactions in our database — the Diphenhydramine Hydrochloride, Naproxen Sodium one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Propolis
We haven’t checked that one against Propolis yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Propolis. Pick one to open its full report.
See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium
This page covers Propolis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 13 major · 320 moderate · 45 minor.
From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page
“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”
Reviewed by 2 · Jul 18, 2026
Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page
Taking Propolis as Part of a Dietary Supplement Product? Check It for Interactions
We hold 723 real supplement products containing Propolis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Propolis. Your product may carry other ingredients that interact with Diphenhydramine Hydrochloride, Naproxen Sodium too, on top of Propolis — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Propolis and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#235 of 1,452 supplements looked up here in the last 7 days
#1,250 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Propolis
What is Propolis?
- Cold sores and herpes lesions (topical)
- Sore throat and mouth sores
- Wound and skin healing
- Immune support
- Oral and gum health
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth sores, and minor wounds, but high-quality evidence is limited for most uses. It is generally well tolerated, but allergic reactions can occur, especially in people allergic to bee products.
Other Drugs & Propolis
Browse every other medication we’ve checked against Propolis — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
920 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Meloxicam ›
- Nortriptyline ›
- Propoxyphene ›
Showing 60 of 920 moderate interactions — see all 920 on the Propolis page.
No interaction 1,909 drugs checked — show the list
We also checked Propolis against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Tirzepatide ›
- Docusate ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Isotretinoin ›
- Semaglutide ›
- Metformin ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Doxycycline ›
- Pregabalin ›
- Azithromycin ›
- Lamotrigine ›
- Acyclovir ›
- Levothyroxine, Liothyronine ›
- Gabapentin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Cephalexin ›
- Cyclopentolate ›
- Ezetimibe ›
- Carbidopa, Levodopa ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Levetiracetam ›
- Mannitol ›
- Thyroid Hormone ›
- Insulin Degludec, Liraglutide ›
- Levodopa ›
- Spironolactone ›
- Mitomycin ›
- Canagliflozin, Metformin ›
- Alginic Acid, Aluminum Hydroxide ›
- Dexmethylphenidate ›
- Levothyroxine Sodium ›
- Atenolol ›
- Magnesium Hydroxide (otc Drug) ›
- Minoxidil ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Phentermine, Topiramate ›
- Acarbose ›
- Cefaclor ›
- Daptomycin ›
- Amobarbital, Ephedrine Sulfate ›
- Hydroxychloroquine ›
- Pegunigalsidase Alfa-iwxj ›
- Flutemetamol F-18 ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Digoxin ›
- Hydrochlorothiazide ›
Showing the 60 most looked-up of 1,909 medications checked with no known interaction — see the full Propolis list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diphenhydramine Hydrochloride, Naproxen Sodium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diphenhydramine Hydrochloride, Naproxen Sodium as a medicine that can lower these. This is not an interaction with Propolis — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diphenhydramine Hydrochloride, Naproxen Sodium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Propolis and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions
Can you take Propolis with Diphenhydramine Hydrochloride, Naproxen Sodium?
Why are there 3 interactions listed for Propolis and Diphenhydramine Hydrochloride, Naproxen Sodium?
How serious is the Propolis and Diphenhydramine Hydrochloride, Naproxen Sodium interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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