Drug & supplement interaction

Pulsatilla + Voriconazole

Voriconazole brand name: Vfend.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Pulsatilla and Voriconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pulsatilla and Voriconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voriconazole and Pulsatilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pulsatilla at all — not against Voriconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pulsatilla safety at a glance

Pulsatilla overall Use caution The fresh plant is toxic and irritating; only properly dried or highly diluted homeopathic forms are used, and evidence is limited.
Pregnancy Likely Unsafe When used orally. The fresh or dried above ground parts are contraindicated due to abortifacient and teratogenic effects. ...when the fresh above ground parts a... Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh above ground parts are used for oral or topical use. There is insufficient reliable information available about the safety of dried pulsatilla du... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voriconazole and Pulsatilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Pulsatilla and Voriconazole May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Pulsatilla

    “Orally, fresh pulsatilla is a toxic gastrointestinal irritant (4,19). It can also cause kidney and urinary tract irritation (2).

    Topically, contact with the fresh plant can cause skin irritation, mucous membrane irritation, itching, and pustule formation known as ranunculus dermatitis (2).”

    Pulsatilla · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    3. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    “Topically, contact with the fresh plant can cause skin irritation, mucous membrane irritation, itching, and pustule formation known as ranunculus dermatitis (2).”

    Pulsatilla · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Voriconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Voriconazole. Read the label on DailyMed ›

Reported for Pulsatilla but not commonly for Voriconazole: an allergic reaction and itching.

Effects for Voriconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Pulsatilla come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Pulsatilla in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. The fresh or dried above ground parts are contraindicated due to abortifacient and teratogenic effects. ...when the fresh above ground parts are used topically. There is insufficient reliable information available about the safety of topical dried pulsatilla during pregnancy.

Lactation Likely Unsafe

When the fresh above ground parts are used for oral or topical use. There is insufficient reliable information available about the safety of dried pulsatilla during breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Voriconazole

This page covers Pulsatilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voriconazole page lists 205 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 159 moderate · 40 minor.

From our pharmacist’s overview on the Voriconazole page

“Voriconazole (Vfend) is a heavy-hitter antifungal, usually prescribed for dangerous infections like invasive aspergillosis, and its list of 205 interacting supplements includes six rated major, enough that anyone on this drug should read those entries before touching a supplement bottle. Most interactions run through the liver enzymes…”

Reviewed by 2 · Jul 18, 2026

Open the Voriconazole interaction page

One more smart check

Taking Pulsatilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 65 real supplement products containing Pulsatilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pulsatilla. Even though Pulsatilla itself has no known interaction with Voriconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pulsatilla and Voriconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pulsatilla
Steady interest

#870 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voriconazole
Steady interest

#2,062 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pulsatilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pulsatilla and Voriconazole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pulsatilla

What is Pulsatilla?

  • Menstrual and PMS-related complaints
  • Anxiety, moodiness, and weepiness (traditional/homeopathic)
  • Earache and cold symptoms (homeopathic)
  • Eye irritation and sinus complaints
  • Sleep and restlessness

Pulsatilla is a flowering plant in the buttercup family that is most often used today in homeopathic (highly diluted) preparations. The fresh plant is toxic and irritating, so it must never be eaten raw, and high-quality human evidence for its benefits is lacking. Talk with your pharmacist or doctor before using any Pulsatilla product, and avoid it during pregnancy and breastfeeding.

Pulsatilla vulgaris · Ranunculaceae · Aerial parts (dried whole flowering plant); used dried, never fresh · Homeopathic pellets and liquid dilutions, dried herb, tincture

An interaction check asks whether these two react with each other — it does not ask whether Pulsatilla is a good idea for someone in your situation. Here is what our Pulsatilla record says about it on its own.

Pulsatilla: dosing

There is no well-established, standardized dose of Pulsatilla for any health condition. Homeopathic products come in different potencies (such as 6C or 30C) and are dosed according to the label or a practitioner's directions, not by milligrams.Because the raw plant is toxic, you should never make or take a homemade preparation.

From our Pulsatilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pulsatilla monograph & all interactions
Medication

About Voriconazole

What Is Voriconazole Used For?

Brand name: Vfend

Voriconazole treats several serious fungal infections. Across all available forms — tablets, oral suspension, and intravenous (IV) injection — it is used for invasive aspergillosis (a dangerous mold infection), candidemia (Candida fungus in the bloodstream) in patients who are not neutropenic (not severely low on white blood cells), other deep-tissue Candida infections, and serious infections caused by Scedosporium apiospermum or Fusarium species in patients who cannot tolerate or have not responded to other antifungal treatments.

Esophageal candidiasis (a Candida infection of the esophagus, the swallowing tube) is also an approved use for most formulations. Note on the oral tablet form (generic voriconazole tablets): that specific tablet formulation is approved for patients aged 12 to 14 years weighing at least 50 kg, and all patients 15 years and older — not for younger or smaller children. The oral suspension and the IV injection are approved for patients 2 years and older for most of these conditions.

Most-Reported Side Effects for Voriconazole

From FAERS, the FDA’s public side-effect reporting system (30,194 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 1,441 reports
Pneumonia 1,347 reports
Bronchopulmonary aspergillosis 1,051 reports
Aspergillus infection 908 reports
See full Voriconazole drug information
Keep checking

Other Drugs & Pulsatilla

Browse every other medication we’ve checked against Pulsatilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Pulsatilla References

The 3 references that drive our Pulsatilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pulsatilla and Voriconazole Together: Common Questions

Is it safe to take Pulsatilla with Voriconazole?
We do not list a known interaction between Pulsatilla and Voriconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pulsatilla and Voriconazole have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Voriconazole interact with any supplements?
Yes. Voriconazole has documented interactions with 205 supplements in our database — Pulsatilla is not one of them. The Voriconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Voriconazole and Pulsatilla?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.