Drug & supplement interaction

Red Soapwort + Hydrochlorothiazide, Valsartan

Hydrochlorothiazide, Valsartan brand name: Diovan HCT.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Red Soapwort and Hydrochlorothiazide, Valsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Red Soapwort and Hydrochlorothiazide, Valsartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide, Valsartan and Red Soapwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Red Soapwort at all — not against Hydrochlorothiazide, Valsartan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Soapwort safety at a glance

Red Soapwort overall Use caution Its saponins can irritate the digestive tract and may be toxic in larger amounts, so internal use should be approached carefully.
Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide, Valsartan and Red Soapwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Red Soapwort and Hydrochlorothiazide, Valsartan May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Vomiting / Nausea Additional detail

    Red Soapwort

    “Orally, red soapwort has been reported to cause stomach irritation (2), nausea, and vomiting (7).”

    Red Soapwort · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 7. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.

    Hydrochlorothiazide, Valsartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Valsartan. Read the label on DailyMed ›

Effects for Hydrochlorothiazide, Valsartan come from the ADVERSE REACTIONS section of its FDA label; effects for Red Soapwort come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 17,095 voluntary FDA FAERS reports for Hydrochlorothiazide, Valsartan that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Valsartan

This page covers Red Soapwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Valsartan page lists 273 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 226 moderate · 37 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Valsartan page

“Diovan HCT pairs valsartan with the water pill hydrochlorothiazide to bring blood pressure down, and the 273 supplements listed here deserve genuine care, ten of them rated major. Most of the moderate entries either drop blood pressure further than intended or blunt the medication, and a second large group compounds the diuretic action…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Valsartan interaction page

One more smart check

Taking Red Soapwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Red Soapwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Soapwort. Even though Red Soapwort itself has no known interaction with Hydrochlorothiazide, Valsartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Soapwort and Hydrochlorothiazide, Valsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Soapwort
Steady interest

#927 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Valsartan
Top 25%

#483 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Soapwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red Soapwort and Hydrochlorothiazide, Valsartan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Soapwort

What is Red Soapwort?

  • Natural soap and shampoo making
  • Cough and chest congestion (traditional)
  • Skin conditions like eczema and itching (topical, traditional)
  • Mild inflammation (traditional)
  • Digestive complaints (traditional)

Red soapwort (Saponaria officinalis) is a soap-making plant that has been used in folk medicine as a cough remedy and skin wash. There is very little reliable human research to support any health claim, and its saponins can irritate the gut and even be toxic if too much is swallowed, so it is mainly used externally or as a natural cleanser. Talk with a pharmacist or doctor before using it medicinally.

Saponaria officinalis · Caryophyllaceae · Root and aerial parts (leaves and stems) · Dried root, tea/decoction, liquid extract, topical washes, and as a natural cleanser in soaps and shampoos

An interaction check asks whether these two react with each other — it does not ask whether Red Soapwort is a good idea for someone in your situation. Here is what our Red Soapwort record says about it on its own.

Red Soapwort: dosing

There is no well-established or standardized medicinal dose for red soapwort. Because of its saponin content and the risk of digestive irritation or toxicity, there is no safe "recommended" amount for internal use that has been confirmed by good research.If you use a commercial product (such as a soapwort-based soap, shampoo, or labeled supplement), follow the directions on the package.

From our Red Soapwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Soapwort monograph & all interactions
Keep checking

Other Drugs & Red Soapwort

Browse every other medication we’ve checked against Red Soapwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Red Soapwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Red Soapwort list.

See the full Red Soapwort interactions page
See every supplement checked against Hydrochlorothiazide, Valsartan, ranked by severity
Evidence & sources

Red Soapwort References

The 2 references that drive our Red Soapwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Soapwort and Hydrochlorothiazide, Valsartan Together: Common Questions

Is it safe to take Red Soapwort with Hydrochlorothiazide, Valsartan?
We do not list a known interaction between Red Soapwort and Hydrochlorothiazide, Valsartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Red Soapwort and Hydrochlorothiazide, Valsartan have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Hydrochlorothiazide, Valsartan interact with any supplements?
Yes. Hydrochlorothiazide, Valsartan has documented interactions with 273 supplements in our database — Red Soapwort is not one of them. The Hydrochlorothiazide, Valsartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Soapwort monograph Uses, safety profile, and every drug interaction in one place Hydrochlorothiazide, Valsartan supplement interactions Every supplement checked against Hydrochlorothiazide, Valsartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide, Valsartan and Red Soapwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.