Drug & supplement interaction

Rutin + Ibuprofen

Ibuprofen brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rutin and Ibuprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rutin and Ibuprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ibuprofen and Rutin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rutin safety at a glance

Rutin overall Use caution Generally well tolerated in food and short-term supplement use, but high-quality long-term safety data are limited.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the use of supplemental rutin; avoid amounts gre... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the use of supplemental rutin; avoid amounts gre... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ibuprofen and Rutin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ibuprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ibuprofen is filed under 10 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Rutin has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Ibuprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rutin Does Interact With Other Medications

Rutin has 86 moderate known drug interactions in our database — Ibuprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Rutin

Covers the 2,830 medications we’ve checked against Rutin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rutin and Ibuprofen May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 5.8% of FDA reports for Ibuprofen Additional detail

    Rutin

    “Orally, rutin may cause headache in some people.”

    Rutin · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 313. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.

    Ibuprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ibuprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Rutin but not commonly for Ibuprofen: flushing.

Effects for Ibuprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Rutin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 283,500 voluntary FDA FAERS reports for Ibuprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rutin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the use of supplemental rutin; avoid amounts greater than those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Ibuprofen Is Prescribed For, and What Rutin Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ibuprofen is a prescription medicine with approved uses on its FDA label. Rutin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ibuprofen is prescribed for: Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods). Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Rutin has been studied for:

  • Osteoarthritis studied, not established Rutin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Rutin for osteoarthritis

    Oral rutin has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ibuprofen on your own; if you are taking Rutin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Rutin or Ibuprofen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rutin or Ibuprofen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen

This page covers Rutin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen page lists 286 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 243 moderate · 36 minor.

From our pharmacist’s overview on the Ibuprofen page

“Most people treat ibuprofen (Advil, Motrin) as an everyday pain reliever, which is exactly why this list of 286 interacting supplements deserves real attention rather than a shrug. The dominant pattern by far is bleeding: 202 of these ingredients can add to the bleeding and stomach irritation ibuprofen already causes, and the seven maj…”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen interaction page

One more smart check

Taking Rutin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,711 real supplement products containing Rutin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rutin. Even though Rutin itself has no known interaction with Ibuprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rutin and Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rutin
Top 10%

#89 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen
Top 1%

#19 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rutin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rutin and Ibuprofen records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rutin

What is Rutin?

  • Varicose veins and chronic venous insufficiency
  • Hemorrhoids
  • Easy bruising and fragile capillaries
  • Swelling (edema) in the legs
  • General antioxidant support

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limited and mostly preliminary, so it should not replace proven treatments. It is generally well tolerated, but talk to your pharmacist or doctor before starting it, especially if you are pregnant or breastfeeding.

A flavonoid found in many plants, such as buckwheat, citrus fruits, apples, and tea · Tablets, capsules, powders, and combination supplements (sometimes with vitamin C or other bioflavonoids)

An interaction check asks whether these two react with each other — it does not ask whether Rutin is a good idea for someone in your situation. Here is what our Rutin record says about it on its own.

Rutin: dosing

There is no official, standardized dose of rutin. Different products contain different amounts, and rutin is often combined with other ingredients.Because a proven safe and effective dose has not been clearly established, the best approach is to follow the directions on the product label and not take more than recommended.

From our Rutin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rutin monograph & all interactions
Medication

About Ibuprofen

What Is Ibuprofen Used For?

Brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, Ibugel Forte, Arthrofen, Ebufac, Rimafen, Calprofen, Fenpaed, Galprofen, Nurofen for Children, Orbifen for Children, Brufen, Brufen Retard, Fenbid, Tab-Profen, Ibuprofen, Calodor

Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods).

Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Most-Reported Side Effects for Ibuprofen

From FAERS, the FDA’s public side-effect reporting system (283,500 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 18,755 reports
Nausea 18,290 reports
Headache 16,566 reports
Arthralgia 13,469 reports
Dyspnea 13,139 reports
See full Ibuprofen drug information
Keep checking

Other Drugs & Rutin

Browse every other medication we’ve checked against Rutin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Rutin page.

No interaction 2,743 drugs checked — show the list

We also checked Rutin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Rutin list.

See the full Rutin interactions page
See every supplement checked against Ibuprofen, ranked by severity
Evidence & sources

Rutin References

The 2 references that drive our Rutin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rutin and Ibuprofen Together: Common Questions

Is it safe to take Rutin with Ibuprofen?
We do not list a known interaction between Rutin and Ibuprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rutin and Ibuprofen have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Rutin and Ibuprofen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Rutin in each. That is a conversation for your prescriber, especially if Ibuprofen is being adjusted to a target.
How was the Rutin and Ibuprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ibuprofen is filed under 10 classifications, and Rutin has documented interactions with 1 drug class — none of Ibuprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rutin interact with any other medications?
Yes. Rutin has 86 documented drug interactions in our database — Ibuprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ibuprofen interact with any supplements?
Yes. Ibuprofen has documented interactions with 286 supplements in our database — Rutin is not one of them. The Ibuprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rutin monograph Uses, safety profile, and every drug interaction in one place Ibuprofen drug information The full plain-English guide to this medication Ibuprofen supplement interactions Every supplement checked against Ibuprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ibuprofen and Rutin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.