Sage + Aspirin, Carisoprodol, Codeine Phosphate
Aspirin, Carisoprodol, Codeine Phosphate brand name: Soma Compound w/ Codeine.
Aspirin, Carisoprodol, Codeine Phosphate falls into 3 drug categories that Sage can interact with; the most serious is rated moderate. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full interaction reportSage and Aspirin, Carisoprodol, Codeine Phosphate
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Sage interacts with whole categories of medication. Aspirin, Carisoprodol, Codeine Phosphate falls into 3 of those categories, so it can interact with Sage in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 3Why this applies to Aspirin, Carisoprodol, Codeine Phosphate
Aspirin, Carisoprodol, Codeine Phosphate falls under CNS DEPRESSANTS — the group Sage interacts with.
Some constituents of sage have CNS depressant activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill (Soma Compound with Codeine) already does a lot to slow down your nervous system. The carisoprodol is a muscle relaxer, and the codeine is an opioid pain reliever, so together they can make you drowsy, foggy, dizzy, or slow your breathing. The concern here is that some natural compounds in sage may also have a mild calming, sedating effect of their own.
Stacking sage on top of this medicine could, in theory, add to that sleepiness and make those effects stronger. I want to be honest, though: this is based only on lab and animal data, not on real patient cases, so it's a fairly weak signal. A sprinkle of sage in cooking is very unlikely to matter. Concentrated sage extracts or the essential oil are where I'd be more cautious. If you take sage supplements regularly, just run it by your pharmacist or doctor first.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Aspirin, Carisoprodol, Codeine Phosphate also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this combo product: the codeine part is actually a prodrug. Your body uses an enzyme called CYP2D6 to turn codeine into morphine, which is what gives you the pain relief. Lab studies hint that sage might slow that same enzyme down. If that happened, less codeine would convert to morphine, so you could get weaker pain relief than expected. The aspirin and carisoprodol pieces aren't really the concern here.
The good news: this is only seen in test-tube studies, never reported in real people, so I wouldn't lose sleep over a little sage in your cooking. Concentrated sage extracts or the essential oil are a different story. If you use those regularly, just check with your pharmacist or doctor first.
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007 Nov;101:350-8.
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
3 of 3Aspirin, Carisoprodol, Codeine Phosphate also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill mixes aspirin, the muscle relaxer carisoprodol, and codeine. The piece that touches sage is carisoprodol, which your body partly handles using a liver enzyme called CYP2C19. In test-tube studies, water-based sage extracts seemed to slow that enzyme down. If that happened in people, carisoprodol could build up a bit, which might leave you feeling extra drowsy, dizzy, or unsteady, especially since codeine already adds to that sleepy effect.
Here's the reassuring part: this is only lab data, and it has not been seen in real patients. Sprinkling sage on your food is very unlikely to matter. Concentrated sage capsules or oil are the bigger question mark, so just run those by your pharmacist or doctor first.
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Sage Also Interacts With Other Medications
Sage has 1,295 moderate known drug interactions in our database — the Aspirin, Carisoprodol, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Sage
We haven’t checked that one against Sage yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Sage. Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Carisoprodol, Codeine Phosphate
This page covers Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Carisoprodol, Codeine Phosphate page lists 339 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 11 major · 292 moderate · 36 minor.
From our pharmacist’s overview on the Aspirin, Carisoprodol, Codeine Phosphate page
“Soma Compound with Codeine packs aspirin, carisoprodol, and codeine into one tablet, and I read its list of 339 interacting supplement ingredients as a genuine warning, not fine print. Most, 202 of them, can add to aspirin's blood-thinning effect and raise bleeding risk.”
Reviewed by 2 · Jul 18, 2026
Open the Aspirin, Carisoprodol, Codeine Phosphate interaction page
Taking Sage as Part of a Dietary Supplement Product? Check It for Interactions
We hold 718 real supplement products containing Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sage. Your product may carry other ingredients that interact with Aspirin, Carisoprodol, Codeine Phosphate too, on top of Sage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Sage and Aspirin, Carisoprodol, Codeine Phosphate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#254 of 1,452 supplements looked up here in the last 7 days
#666 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Sage
What is Sage?
- Sore throat and mouth irritation
- Digestive upset
- Excessive sweating
- Memory and thinking
- Menopause symptoms (hot flashes)
- General antioxidant support
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore throat and menopausal hot flashes, but most uses are not well proven. Concentrated extracts and the essential oil should be used carefully because high doses contain a compound called thujone, which can be harmful.
Other Drugs & Sage
Browse every other medication we’ve checked against Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,295 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Glycopyrrolate ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Ipratropium ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Procainamide ›
- Trimipramine ›
- Acetaminophen ›
Showing 60 of 1,295 moderate interactions — see all 1,295 on the Sage page.
No interaction 1,534 drugs checked — show the list
We also checked Sage against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Bupropion ›
- Amoxicillin ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Dexmethylphenidate ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Factor 7a ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Mitomycin ›
- Lenvatinib ›
- Ezetimibe ›
- Cefaclor ›
- Hethylphenidate Hcl ›
- Phenylephrine ›
- Vancomycin ›
- Bentoquatam ›
- Tenecteplase ›
- Amoxicillin, Clavulanate Potassium ›
- Hydroxychloroquine ›
- Dirithromycin ›
- Triptorelin ›
- Pizotifen ›
- Tocainide ›
- Azelaic Acid ›
- Acetylsalicylic Acid ›
- Dextrothyroxine ›
- Lomustine ›
- Rocuronium ›
- Mitomycin C ›
- Chenodiol ›
- Desflurane ›
- Gestodene ›
- Succimer ›
- Digitoxin ›
- Niacin (prescription Drug) ›
- Halothane ›
- Caspofungin ›
Showing the 60 most looked-up of 1,534 medications checked with no known interaction — see the full Sage list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Carisoprodol, Codeine Phosphate Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Aspirin, Carisoprodol, Codeine Phosphate as a medicine that can lower these. This is not an interaction with Sage — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Carisoprodol, Codeine Phosphate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sage and Aspirin, Carisoprodol, Codeine Phosphate Together: Common Questions
Can you take Sage with Aspirin, Carisoprodol, Codeine Phosphate?
Why are there 3 interactions listed for Sage and Aspirin, Carisoprodol, Codeine Phosphate?
How serious is the Sage and Aspirin, Carisoprodol, Codeine Phosphate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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