Drug & supplement interaction

Sceletium + Dupilumab

Dupilumab brand name: Dupixent.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sceletium and Dupilumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sceletium and Dupilumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dupilumab and Sceletium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sceletium safety at a glance

Sceletium overall Use caution It appears generally tolerable in small studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety data are lacking, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dupilumab and Sceletium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Sceletium Does Interact With Other Medications

Sceletium has 248 moderate known drug interactions in our database — Dupilumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Dupilumab)
Taking anything else?

Check Another of Your Medications Against Sceletium

Covers the 2,830 medications we’ve checked against Sceletium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sceletium and Dupilumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Trouble sleeping / Headache Additional detail

    Sceletium

    “Orally, a sceletium extract has been reported to cause anxiety, headache, insomnia, and irritability. There are also anecdotal reports that chewing sceletium can cause headache, depression, and listlessness. Additionally, anecdotal reports suggest that sceletium can cause euphoric effects when inhaled or taken orally in high doses.”

    Sceletium · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 106745. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed
    2. 17580. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
    3. 100649. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum

    Dupilumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Dupilumab. Read the label on DailyMed ›

Reported for Sceletium but not commonly for Dupilumab: reduced appetite, mood changes or irritability, raised blood pressure and low mood.

Effects for Dupilumab come from the ADVERSE REACTIONS section of its FDA label; effects for Sceletium come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 478,975 voluntary FDA FAERS reports for Dupilumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

One more smart check

Taking Sceletium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 132 real supplement products containing Sceletium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sceletium. Even though Sceletium itself has no known interaction with Dupilumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sceletium and Dupilumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sceletium
Top half

#370 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dupilumab
Steady interest

#1,848 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sceletium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sceletium and Dupilumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sceletium

What is Sceletium?

  • Anxiety and stress
  • Low mood
  • Mental focus and cognition
  • Relaxation
  • Traditional use as a mood lifter

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk to your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Sceletium tortuosum · Aizoaceae · Aerial parts (leaves, stems, and flowers), often fermented · Capsules, tablets, powders, tinctures, chewed plant material, and tea

An interaction check asks whether these two react with each other — it does not ask whether Sceletium is a good idea for someone in your situation. Here is what our Sceletium record says about it on its own.

Sceletium: dosing

There is no official, well-established dose for Sceletium. Products differ greatly in their strength and in how they are prepared and standardized.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Sceletium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sceletium monograph & all interactions
Medication

About Dupilumab Injection

What Is Dupilumab Injection Used For?

Brand name: Dupixent

Dupixent (dupilumab) injection is approved for several inflammatory conditions. It treats moderate-to-severe atopic dermatitis (eczema) in patients 6 months and older when topical treatments haven't worked well enough. It is also used as an add-on maintenance treatment for moderate-to-severe asthma (ages 6 and up), chronic rhinosinusitis with nasal polyps (ages 12 and up), and COPD with an eosinophilic phenotype in adults.

Additionally, Dupixent treats eosinophilic esophagitis (EoE, a chronic inflammatory condition of the esophagus) in patients 1 year and older weighing at least 15 kg, prurigo nodularis (severe itchy skin nodules) in adults, chronic spontaneous urticaria (hives without a clear trigger) in patients 2 and older who haven't responded to antihistamines, bullous pemphigoid (a blistering skin disease) in adults, and allergic fungal rhinosinusitis in patients 6 and older with a history of sinus surgery. It is not for relief of sudden or acute breathing attacks.

Most-Reported Side Effects for Dupilumab

From FAERS, the FDA’s public side-effect reporting system (478,975 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 58,692 reports
Dermatitis atopic 45,026 reports
Rash 38,629 reports
Injection site pain 36,707 reports
Eczema 26,626 reports
See full Dupilumab Injection drug information
Keep checking

Other Drugs & Sceletium

Browse every other medication we’ve checked against Sceletium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Sceletium page.

No interaction 2,581 drugs checked — show the list

We also checked Sceletium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Sceletium list.

See the full Sceletium interactions page
See every supplement checked against Dupilumab, ranked by severity
Evidence & sources

Sceletium References

The 3 references that drive our Sceletium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sceletium and Dupilumab Together: Common Questions

Is it safe to take Sceletium with Dupilumab?
We do not list a known interaction between Sceletium and Dupilumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sceletium and Dupilumab have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Sceletium interact with any other medications?
Yes. Sceletium has 248 documented drug interactions in our database — Dupilumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sceletium monograph Uses, safety profile, and every drug interaction in one place Dupilumab Injection drug information The full plain-English guide to this medication Dupilumab supplement interactions Every supplement checked against Dupilumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dupilumab and Sceletium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.