Drug & supplement interaction

Sea Moss + Rilonacept

Rilonacept brand name: Arcalyst.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Sea Moss and Rilonacept in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sea Moss and Rilonacept

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rilonacept and Sea Moss in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sea Moss safety at a glance

Sea Moss overall Use caution Generally seen as food, but variable iodine levels and possible heavy-metal content warrant caution.

Pregnancy Likely Safe When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using. Read the full pregnancy detail

Breastfeeding Likely Safe When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rilonacept and Sea Moss? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Sea Moss Does Interact With Other Medications

Sea Moss has 22 moderate known drug interactions in our database — Rilonacept isn’t one of them. If you take anything else, check it against the full list below.

Moderate 22 No known interaction 2,808 (incl. Rilonacept)

Taking anything else?

Check Another of Your Medications Against Sea Moss

Covers the 2,830 medications we’ve checked against Sea Moss. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sea Moss and Rilonacept May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Diarrhea Additional detail
Sea Moss
“Orally, see moss has been reported to cause constipation and diarrhea in one observational study.”

Sea Moss · Natural Medicines adverse-effect record, reported in constipation.
1 source cited

109121. Palmieri B, Vadalà M, Laurino C. Clinical effects of overwintered-stressed Chondrus Crispus and non-overwintered-stressed Chondrus crispus dietary supplementations. Asian J Med Sci. 2018; 9(6): 7-13. DOI
Rilonacept

Listed in the ADVERSE REACTIONS section of the FDA label for Rilonacept. Read the label on DailyMed ›

Reported for Sea Moss but not commonly for Rilonacept: constipation.

Effects for Rilonacept come from the ADVERSE REACTIONS section of its FDA label; effects for Sea Moss come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sea Moss in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Rilonacept Is Prescribed For, and What Sea Moss Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Rilonacept is a prescription medicine with approved uses on its FDA label. Sea Moss is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Rilonacept is prescribed for: Arcalyst (rilonacept) is approved to treat Cryopyrin-Associated Periodic Syndromes (CAPS) — including Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS) — in adults and children 12 and older. It is also used to maintain remission of Deficiency of Interleukin-1 Receptor Antagonist (DIRA) in adults and children weighing at least 10 kg (about 22 lbs). Arcalyst is also approved to treat recurrent pericarditis (repeated episodes of inflammation around the heart) and to lower the risk of it coming back, in adults and children 12 and older.

Sea Moss has been studied for:

Fatigue studied, not established Sea Moss has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Sea Moss for fatigue

It is unclear if oral sea moss is beneficial for increasing energy.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Rilonacept on your own; if you are taking Sea Moss for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Sea Moss or Rilonacept

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sea Moss or Rilonacept, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

How much people look this up

Where Sea Moss and Rilonacept Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sea Moss

Top half

#413 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Rilonacept

Steady interest

#1,425 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sea Moss reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sea Moss and Rilonacept records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Sea Moss

What is Sea Moss?

Source of iodine and minerals
Thyroid support
Respiratory issues and cough
Digestive support
Skin and hair health
General immune and antioxidant support

Sea moss is a type of red seaweed that is naturally rich in iodine and several minerals, and it is popular as a 'whole-food' supplement. Strong human evidence for most of its health claims is lacking, and its high and variable iodine content can be a real concern, especially for people with thyroid problems. Talk to your pharmacist or doctor before using it, particularly if you are pregnant, breastfeeding, or have a thyroid condition.

Chondrus crispus · Gigartinaceae · Whole dried seaweed (thallus) · Gel, dried raw seaweed, capsules, powder, gummies, drinks, skin products

An interaction check asks whether these two react with each other — it does not ask whether Sea Moss is a good idea for someone in your situation. Here is what our Sea Moss record says about it on its own.

Sea Moss: dosing

There is no established, standardized dose for sea moss. Iodine content varies widely between products, which makes consistent dosing difficult and increases the risk of getting too much.If you choose to use it, follow the directions on the product label and start low.

From our Sea Moss monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sea Moss monograph & all interactions

Medication

About Rilonacept Injection

What Is Rilonacept Injection Used For?

Brand name: Arcalyst

Arcalyst (rilonacept) is approved to treat Cryopyrin-Associated Periodic Syndromes (CAPS) — including Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS) — in adults and children 12 and older. It is also used to maintain remission of Deficiency of Interleukin-1 Receptor Antagonist (DIRA) in adults and children weighing at least 10 kg (about 22 lbs).

Arcalyst is also approved to treat recurrent pericarditis (repeated episodes of inflammation around the heart) and to lower the risk of it coming back, in adults and children 12 and older.

Most-Reported Side Effects for Rilonacept

From FAERS, the FDA’s public side-effect reporting system (1,121 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site erythema 132 reports

Chest pain 115 reports

Fatigue 89 reports

Injection site pain 87 reports

Pericarditis 84 reports

See full Rilonacept Injection drug information

Keep checking

Other Drugs & Sea Moss

Browse every other medication we’ve checked against Sea Moss — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

22Moderate

0Minor

2,807No known interaction

22 Moderate 2,807 No interaction

Moderate

22 interactions

No interaction 2,807 drugs checked — show the list

We also checked Sea Moss against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,807 medications checked with no known interaction — see the full Sea Moss list.

See the full Sea Moss interactions page

See every supplement checked against Rilonacept, ranked by severity

Evidence & sources

Sea Moss References

The 3 references that drive our Sea Moss monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Darias-Rosales J, Rubio C, Gutiérrez ÁJ, Paz S, Hardisson A. Risk assessment of iodine intake from the consumption of red seaweeds (Palmaria palmata and Chondrus crispus). Environ Sci Pollut Res Int 2020;27(36):45737-45741. PubMed
U.S. Department of Agriculture (USDA). Agricultural Research Service. FoodData Central. Seaweed, irishmoss, raw. April 2019. Available at: https://fdc.nal.usda.gov/fdc-app.html#/food-details/168456/nutrients. Accessed Aug. 30, 2022.
Palmieri B, Vadalà M, Laurino C. Clinical effects of overwintered-stressed Chondrus Crispus and non-overwintered-stressed Chondrus crispus dietary supplementations. Asian J Med Sci. 2018; 9(6): 7-13. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sea Moss and Rilonacept Together: Common Questions

Is it safe to take Sea Moss with Rilonacept?

We do not list a known interaction between Sea Moss and Rilonacept. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Sea Moss and Rilonacept have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Sea Moss and Rilonacept used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sea Moss in each. That is a conversation for your prescriber, especially if Rilonacept is being adjusted to a target.

Does Sea Moss interact with any other medications?

Yes. Sea Moss has 22 documented drug interactions in our database — Rilonacept is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sea Moss monograph Uses, safety profile, and every drug interaction in one place Rilonacept Injection drug information The full plain-English guide to this medication Rilonacept supplement interactions Every supplement checked against Rilonacept, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rilonacept and Sea Moss?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.