Drug & supplement interaction

Serrapeptase + Dextromethorphan, Guaifenesin, Psuedoephedrine

Dextromethorphan, Guaifenesin, Psuedoephedrine brand name: Aquatab C.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan, Guaifenesin, Psuedoephedrine and Serrapeptase in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Serrapeptase safety at a glance

Serrapeptase overall Use caution Generally tolerated short-term, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan, Guaifenesin, Psuedoephedrine and Serrapeptase? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dextromethorphan, Guaifenesin, Psuedoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextromethorphan, Guaifenesin, Psuedoephedrine is filed under 8 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. Serrapeptase has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Dextromethorphan, Guaifenesin, Psuedoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Serrapeptase Does Interact With Other Medications

Serrapeptase has 122 moderate known drug interactions in our database — Dextromethorphan, Guaifenesin, Psuedoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Dextromethorphan, Guaifenesin, Psuedoephedrine)
Taking anything else?

Check Another of Your Medications Against Serrapeptase

Covers the 2,830 medications we’ve checked against Serrapeptase. Pick one to open its full report.

What to actually watch for

What Serrapeptase Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan, Guaifenesin, Psuedoephedrine. It is the side-effect record for Serrapeptase on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Serrapeptase, this list is the first place to look.

  • Stomach upset / Nausea Additional detail

    “Orally, some patients have reported experiencing epigastric pain, gastrointestinal upset, and nausea; however, these side effects appear to occur at the same rate as placebo.”

    Serrapeptase · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 13152. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Serrapeptase — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan, Guaifenesin, Psuedoephedrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan, Guaifenesin, Psuedoephedrine.

From our Q&A

Questions About Serrapeptase or Dextromethorphan, Guaifenesin, Psuedoephedrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Serrapeptase or Dextromethorphan, Guaifenesin, Psuedoephedrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dextromethorphan, Guaifenesin, Psuedoephedrine

This page covers Serrapeptase only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan, Guaifenesin, Psuedoephedrine page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Lithium (major) and Peyote (major).

By severity: 8 major · 148 moderate · 41 minor.

From our pharmacist’s overview on the Dextromethorphan, Guaifenesin, Psuedoephedrine page

“A cold and congestion remedy sounds low stakes, but Aquatab C (dextromethorphan, guaifenesin, and pseudoephedrine) earns real caution. Eight of the 197 supplements and herbs on file carry a major rating, and those deserve your attention first.”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan, Guaifenesin, Psuedoephedrine interaction page

One more smart check

Taking Serrapeptase as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Serrapeptase, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Serrapeptase. Even though Serrapeptase itself has no known interaction with Dextromethorphan, Guaifenesin, Psuedoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Serrapeptase
Top half

#452 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextromethorphan, Guaifenesin, Psuedoephedrine
Steady interest

#2,022 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Serrapeptase reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Serrapeptase

What is Serrapeptase?

  • Inflammation and swelling
  • Sinus and respiratory congestion
  • Pain after surgery or injury
  • Joint and back pain
  • Thinning mucus

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coated product, follow the label, and check with your pharmacist or doctor first—especially if you are pregnant, breastfeeding, or take other medicines.

Enzyme produced by bacteria (Serratia species) found in silkworms · Tablets, capsules (often enteric-coated)

An interaction check asks whether these two react with each other — it does not ask whether Serrapeptase is a good idea for someone in your situation. Here is what our Serrapeptase record says about it on its own.

Serrapeptase: dosing

There is no official or well-established dose for serrapeptase. Products are often measured in enzyme "units" rather than simple milligrams, and these vary between brands.The best approach is to follow the directions on the product label and not exceed them.

From our Serrapeptase monograph — the full record covers uses, side effects and every documented interaction.

Read the full Serrapeptase monograph & all interactions
Keep checking

Other Drugs & Serrapeptase

Browse every other medication we’ve checked against Serrapeptase — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Serrapeptase page.

No interaction 2,707 drugs checked — show the list

We also checked Serrapeptase against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Serrapeptase list.

See the full Serrapeptase interactions page
See every supplement checked against Dextromethorphan, Guaifenesin, Psuedoephedrine, ranked by severity
Evidence & sources

Serrapeptase References

The 2 references that drive our Serrapeptase monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine Together: Common Questions

Is it safe to take Serrapeptase with Dextromethorphan, Guaifenesin, Psuedoephedrine?
We do not list a known interaction between Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Serrapeptase and Dextromethorphan, Guaifenesin, Psuedoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Dextromethorphan, Guaifenesin, Psuedoephedrine is filed under 8 classifications, and Serrapeptase has documented interactions with 1 drug class — none of Dextromethorphan, Guaifenesin, Psuedoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Serrapeptase interact with any other medications?
Yes. Serrapeptase has 122 documented drug interactions in our database — Dextromethorphan, Guaifenesin, Psuedoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dextromethorphan, Guaifenesin, Psuedoephedrine interact with any supplements?
Yes. Dextromethorphan, Guaifenesin, Psuedoephedrine has documented interactions with 197 supplements in our database — Serrapeptase is not one of them. The Dextromethorphan, Guaifenesin, Psuedoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Serrapeptase monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan, Guaifenesin, Psuedoephedrine supplement interactions Every supplement checked against Dextromethorphan, Guaifenesin, Psuedoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan, Guaifenesin, Psuedoephedrine and Serrapeptase?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.