Drug & supplement interaction

Sorrel + Levothyroxine Sodium

Levothyroxine Sodium brand names: Tirosint-Sol, Thyquidity, Ermez.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sorrel and Levothyroxine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Levothyroxine Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sorrel and Levothyroxine Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levothyroxine Sodium and Sorrel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sorrel safety at a glance

Sorrel overall Use caution Generally safe as a food in normal amounts, but high oxalate content can be a concern with large or concentrated doses.
Pregnancy Possibly Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts d... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts d... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Sorrel has few documented, clinically significant, drug interactions. Preliminary research in animals indicates it may interact with antiplatelet drugs and drugs that are a substrate for transporter proteins known as OATPs (Organic Anion Transporting Polypeptides).

It is unlikely sorrel has clinically significant drug interactions, and there is no known drug interaction between the drug in this monograph and sorrel. As always however, be sure to let your doctor know about all the medications you are taking so you can be appropriately monitored.

—

Still wondering about combining Levothyroxine Sodium and Sorrel? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levothyroxine Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levothyroxine Sodium is filed under 3 classifications — including thyroid hormone, oral drugs. Sorrel has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), fexofenadine (allegra) (moderate) and organic anion-transporting polypeptide substrates (oatp) (moderate) — and none of Levothyroxine Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sorrel Does Interact With Other Medications

Sorrel has 169 moderate known drug interactions in our database — Levothyroxine Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 169 No known interaction 2,661 (incl. Levothyroxine Sodium)
Taking anything else?

Check Another of Your Medications Against Sorrel

Covers the 2,830 medications we’ve checked against Sorrel. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sorrel and Levothyroxine Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    Sorrel

    “Environmental exposure to sorrel pollen may trigger allergic rhinitis or bronchial asthma in hypersensitive individuals, and allergic cross-sensitivity may occur in up to 19% of people who are allergic to weed pollen.”

    Sorrel · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 75141. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.

    Levothyroxine Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium. Read the label on DailyMed ›

  • Nausea reported in 7.2% of FDA reports for Levothyroxine Sodium Additional detail

    Sorrel

    “Orally, sorrel, when used in combination with other herbs, has been reported to cause gastrointestinal side effects including nausea and an unpleasant aftertaste.”

    Sorrel · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 374. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
    2. 379. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
    3. 37419. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed

    Levothyroxine Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Sorrel but not commonly for Levothyroxine Sodium: kidney problems, a stuffy or runny nose and passing urine more often.

Effects for Levothyroxine Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Sorrel come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 312,551 voluntary FDA FAERS reports for Levothyroxine Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sorrel in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Levothyroxine Sodium Products Have a Food Rule — Sorrel Should Not Break It

At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach. Most supplements — Sorrel included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine Sodium on its own and move Sorrel to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Sorrel or Levothyroxine Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sorrel or Levothyroxine Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levothyroxine Sodium

This page covers Sorrel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine Sodium page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

Open the Levothyroxine Sodium interaction page

One more smart check

Taking Sorrel as Part of a Dietary Supplement Product? Check It for Interactions

We hold 224 real supplement products containing Sorrel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sorrel. Even though Sorrel itself has no known interaction with Levothyroxine Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sorrel and Levothyroxine Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sorrel
Top 25%

#329 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levothyroxine Sodium
Top 5%

#136 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sorrel reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sorrel and Levothyroxine Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sorrel

What is Sorrel?

Sorrel
  • Sinus and respiratory congestion
  • Digestive upset
  • Fever
  • Skin conditions and inflammation
  • Antioxidant support

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its high oxalate content means it should be used in moderation, especially by people prone to kidney stones.

Rumex acetosa · Polygonaceae · Leaves (and sometimes whole aerial parts) · Fresh leaves in cooking, tea, dried herb, tincture, and as an ingredient in some herbal combination products

An interaction check asks whether these two react with each other — it does not ask whether Sorrel is a good idea for someone in your situation. Here is what our Sorrel record says about it on its own.

Sorrel: dosing

There is no well-established standardized medicinal dose for sorrel. As a food, it is used in normal culinary amounts.When sorrel appears in herbal supplement products, the amount varies by brand. Follow the directions on the product label and do not exceed the recommended dose. Because of the oxalate concern, it is wise to avoid taking large amounts over long periods.

From our Sorrel monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sorrel monograph & all interactions
Medication

About Levothyroxine Sodium

Most-Reported Side Effects for Levothyroxine Sodium

From FAERS, the FDA’s public side-effect reporting system (312,551 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 26,585 reports
Nausea 22,605 reports
Headache 19,408 reports
Diarrhea 18,759 reports
Dyspnea 16,717 reports
Keep checking

Other Drugs & Sorrel

Browse every other medication we’ve checked against Sorrel — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
169Moderate
0Minor
2,660No known interaction
169 Moderate 2,660 No interaction
Moderate

169 interactions

Showing 60 of 169 moderate interactions — see all 169 on the Sorrel page.

No interaction 2,660 drugs checked — show the list

We also checked Sorrel against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,660 medications checked with no known interaction — see the full Sorrel list.

See the full Sorrel interactions page
See every supplement checked against Levothyroxine Sodium, ranked by severity
Evidence & sources

Sorrel References

The 8 references that drive our Sorrel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sorrel and Levothyroxine Sodium Together: Common Questions

Is it safe to take Sorrel with Levothyroxine Sodium?
We do not list a known interaction between Sorrel and Levothyroxine Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sorrel and Levothyroxine Sodium have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Sorrel and Levothyroxine Sodium at the same time of day?
At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Levothyroxine Sodium on its own and move Sorrel to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Sorrel and Levothyroxine Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Levothyroxine Sodium is filed under 3 classifications, and Sorrel has documented interactions with 3 drug classes — none of Levothyroxine Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sorrel interact with any other medications?
Yes. Sorrel has 169 documented drug interactions in our database — Levothyroxine Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levothyroxine Sodium interact with any supplements?
Yes. Levothyroxine Sodium has documented interactions with 50 supplements in our database — Sorrel is not one of them. The Levothyroxine Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sorrel monograph Uses, safety profile, and every drug interaction in one place Levothyroxine Sodium supplement interactions Every supplement checked against Levothyroxine Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levothyroxine Sodium and Sorrel?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.