Drug & supplement interaction

Squalamine + Trandolapril, Verapamil

Trandolapril, Verapamil brand name: Tarka.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Trandolapril, Verapamil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Trandolapril, Verapamil states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squalamine and Trandolapril, Verapamil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trandolapril, Verapamil and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Trandolapril, Verapamil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trandolapril, Verapamil and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Squalamine and Trandolapril, Verapamil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Squalamine

    “Topically and intravenously, squalamine seems to be well tolerated; however, a thorough safety evaluation has not been conducted.

    Most Common Adverse Effects:

    Intravenously: Fatigue, loss of appetite, myalgia, nausea, transaminitis, vomiting.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    Trandolapril, Verapamil

    Listed in the ADVERSE REACTIONS section of the FDA label for Trandolapril, Verapamil. Read the label on DailyMed ›

  • Tiredness Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Trandolapril, Verapamil

    Listed in the ADVERSE REACTIONS section of the FDA label for Trandolapril, Verapamil. Read the label on DailyMed ›

  • Nausea Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Trandolapril, Verapamil

    Listed in the ADVERSE REACTIONS section of the FDA label for Trandolapril, Verapamil. Read the label on DailyMed ›

Reported for Squalamine but not commonly for Trandolapril, Verapamil: yellowing of the skin or eyes, reduced appetite, muscle pain and vomiting.

Effects for Trandolapril, Verapamil come from the ADVERSE REACTIONS section of its FDA label; effects for Squalamine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Trandolapril, Verapamil Products Have a Food Rule — Squalamine Should Not Break It

At least one FDA label for a product containing Trandolapril, Verapamil says to take it with food. If you take Squalamine on an empty stomach out of habit, keep them separate — and take Trandolapril, Verapamil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Trandolapril, Verapamil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Trandolapril and verapamil hydrochloride extended-release tablets should be administered with food.

From the Dosage and Administration section of the FDA label we read for Trandolapril, Verapamil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Trandolapril, Verapamil

This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trandolapril, Verapamil page lists 304 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 11 major · 250 moderate · 43 minor.

From our pharmacist’s overview on the Trandolapril, Verapamil page

“This is one of the supplement lists I would want a patient to read closely, not skim. Tarka combines trandolapril and verapamil to lower blood pressure, and most of these interactions pull on that same lever, either dropping pressure further than intended or working against the medicine altogether.”

Reviewed by 2 · Jul 18, 2026

Open the Trandolapril, Verapamil interaction page

How much people look this up

Where Squalamine and Trandolapril, Verapamil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#859 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trandolapril, Verapamil
Top 25%

#516 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Squalamine and Trandolapril, Verapamil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Trandolapril, Verapamil, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Trandolapril, Verapamil Together: Common Questions

Is it safe to take Squalamine with Trandolapril, Verapamil?
We do not list a known interaction between Squalamine and Trandolapril, Verapamil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squalamine and Trandolapril, Verapamil have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Squalamine and Trandolapril, Verapamil at the same time of day?
At least one FDA label for a product containing Trandolapril, Verapamil says to take it with food. If you take Squalamine on an empty stomach out of habit, keep them separate and take Trandolapril, Verapamil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Trandolapril, Verapamil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Trandolapril, Verapamil interact with any supplements?
Yes. Trandolapril, Verapamil has documented interactions with 304 supplements in our database — Squalamine is not one of them. The Trandolapril, Verapamil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Trandolapril, Verapamil supplement interactions Every supplement checked against Trandolapril, Verapamil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trandolapril, Verapamil and Squalamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.