Medication interaction hub

What Supplements Interact with Trandolapril, Verapamil?

Trandolapril, Verapamil brand name: Tarka. Every interaction below applies to the brands too.

304 Interactions 11 Major 250 Moderate 43 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Trandolapril, Verapamil? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Trandolapril, Verapamil against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

This is one of the supplement lists I would want a patient to read closely, not skim. Tarka combines trandolapril and verapamil to lower blood pressure, and most of these interactions pull on that same lever, either dropping pressure further than intended or working against the medicine altogether. A second large cluster changes how much drug actually reaches the bloodstream, and grapefruit and St. John's wort sit at opposite ends there, one raising drug levels, the other cutting them.

Heavy alcohol adds liver strain on top of that, and a few herbs can damage the kidneys, a real concern with an ACE inhibitor on board. Potassium supplements deserve extra care as well, since the trandolapril half reduces how much potassium the body clears. Of the 304 ingredients on file, 250 rate moderate and 43 minor, but the 11 marked major are where the reading should begin.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 250 Minor 43 No known interaction 1,148

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Trandolapril, Verapamil: Top Interactions at a Glance

The Trandolapril, Verapamil supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 304 interacting ingredients — plus 1,148 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Trandolapril, Verapamil Combinations Today

The Trandolapril, Verapamil + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Black Psyllium + Trandolapril, Verapamili

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Agmatine + Trandolapril, Verapamili

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Goji + Trandolapril, Verapamili

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Read the full interaction Moderate Likelihood Possible Magnesium + Trandolapril, Verapamili

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Read the full interaction Moderate Likelihood Probable Fish Oil + Trandolapril, Verapamili

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Soy + Trandolapril, Verapamili

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Trandolapril, Verapamil

All 1,452 ingredients in our database, ranked by severity — 304 with a Trandolapril, Verapamil interaction on file and 1,148 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Trandolapril, Verapamil?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Psyllium with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Trandolapril, Verapamil answer

Can you take Agmatine with Trandolapril, Verapamil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Trandolapril, Verapamil answer

Can you take Goji with Trandolapril, Verapamil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Full Goji + Trandolapril, Verapamil answer

Can you take Magnesium with Trandolapril, Verapamil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.

Full Magnesium + Trandolapril, Verapamil answer

Can you take Fish Oil with Trandolapril, Verapamil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Trandolapril, Verapamil answer

Can you take Puravive with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin, which has been found to slightly reduce blood pressure in individuals with mild hypertension (https://pubmed.nc...

Full Puravive + Trandolapril, Verapamil answer

Can you take Stevia with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.

Full Stevia + Trandolapril, Verapamil answer

Can you take Valerian with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Trandolapril, Verapamil answer

Can you take Xanthan Gum with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Trandolapril, Verapamil answer

Can you take Asian Water Plantain with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Trandolapril, Verapamil answer

Can you take Capsicum with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Full Capsicum + Trandolapril, Verapamil answer

Can you take Chrysin with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Trandolapril, Verapamil answer

Can you take Diindolylmethane with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Full Diindolylmethane + Trandolapril, Verapamil answer

Can you take Jequirity with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Trandolapril, Verapamil answer

Can you take Milk Thistle with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Trandolapril, Verapamil answer

Can you take Mommy's Bliss Gripe Water with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Trandolapril, Verapamil answer

Can you take Polypodium Leucotomos with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Trandolapril, Verapamil answer

Can you take Red Clover with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Trandolapril, Verapamil answer

Can you take Rosemary with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Full Rosemary + Trandolapril, Verapamil answer

Can you take Tangerine with Trandolapril, Verapamil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Trandolapril, Verapamil answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Trandolapril, Verapamil is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Trandolapril, Verapamil, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Trandolapril, Verapamil sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Verapamil (Calan, Others) 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Calcium Channel Blockers 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Trandolapril, Verapamil through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Trandolapril, Verapamil through this category.

Related: does Trandolapril, Verapamil deplete any nutrients?

Trandolapril, Verapamil has 2 reported nutrient associations in the research literature — see the Trandolapril, Verapamil nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Trandolapril, Verapamil

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Trandolapril, Verapamil.

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Pharmacist Counseling Corner

Trandolapril, Verapamil & Supplements: Common Questions

What supplements interact with Trandolapril, Verapamil?
Our database currently documents 304 ingredients with a known Trandolapril, Verapamil interaction (11 major, 250 moderate, 43 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 304. The highest-ranked right now: American Hellebore, Grapefruit, Siberian Cocklebur.
Which Trandolapril, Verapamil supplement interactions are the most serious?
Focus on the major group: American Hellebore, Grapefruit, Siberian Cocklebur, Tyramine and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Trandolapril, Verapamil?
Plenty of supplements coexist fine with Trandolapril, Verapamil; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tarka have the same supplement interactions as Trandolapril, Verapamil?
Yes — Tarka all contain Trandolapril, Verapamil, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Trandolapril, Verapamil deplete any vitamins or nutrients?
It might — Trandolapril, Verapamil has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Trandolapril, Verapamil nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Trandolapril, Verapamil and my other medications?
This page covers Trandolapril, Verapamil against supplements and herbal ingredients. Checking Trandolapril, Verapamil against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.