Drug & supplement interaction

Noni + Trandolapril, Verapamil

Trandolapril, Verapamil brand name: Tarka.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Trandolapril, Verapamil falls into 3 drug categories that Noni can interact with; the most serious is rated moderate. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Noni and Trandolapril, Verapamil

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Noni interacts with whole categories of medication. Trandolapril, Verapamil falls into 3 of those categories, so it can interact with Noni in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 3

Why this applies to Trandolapril, Verapamil

Trandolapril, Verapamil falls under ANTIHYPERTENSIVE DRUGS — the group Noni interacts with.

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Tarka combines two blood pressure medicines in one pill: trandolapril (an ACE inhibitor) and verapamil (a calcium channel blocker). Both work to lower your blood pressure. Here's the simple version of the concern: noni juice has shown a mild blood-pressure-lowering effect of its own in some early research. So drinking it regularly on top of Tarka could, in theory, push your numbers down a little too far.

If that happens, you might feel dizzy or lightheaded, especially when standing up, or notice tiredness or a headache. To be honest, this is based on weak, anecdotal evidence, not strong studies, so it isn't a reason to panic. Still, please loop in your pharmacist or doctor before adding noni, and keep an eye on your blood pressure at home.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
Moderate

HEPATOTOXIC DRUGS

2 of 3

Trandolapril, Verapamil also falls under HEPATOTOXIC DRUGS.

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: there have been a few rare reports of noni juice causing liver trouble in certain people. Tarka combines two medicines, trandolapril (a blood pressure medicine) and verapamil. Verapamil, in particular, is processed by your liver and can occasionally affect liver enzymes on its own. So the worry is that stacking noni on top of a medicine your liver already handles might add a little extra strain.

I want to be honest, though: this concern is mostly theoretical and based on scattered case reports, not strong studies. The bigger issue is that verapamil and noni can both lower blood pressure, which could leave you dizzy or lightheaded. Please check with your pharmacist or doctor before adding noni, especially if you have any liver concerns.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  2. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  3. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
Moderate

ACE INHIBITORS (ACEIs)

3 of 3

Trandolapril, Verapamil also falls under ACE INHIBITORS (ACEIs).

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Tarka: it contains trandolapril, which is an ACE inhibitor. One known effect of ACE inhibitors is that they tend to nudge your potassium levels up a bit. Noni juice is naturally pretty rich in potassium (roughly 6 mEq per 100 mL), so drinking a lot of it alongside trandolapril could, in theory, push your potassium higher than you'd want.

If potassium climbs too high (called hyperkalemia), you might feel muscle weakness, tiredness, or notice an irregular heartbeat. I'll be honest though, this concern is based on weak, anecdotal evidence, and an occasional glass of noni juice is unlikely to cause trouble for most people. Regular or concentrated supplement use is more of a question. If you have kidney issues or take other potassium-raising medicines, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Noni Also Interacts With Other Medications

Noni has 540 moderate, 1 minor known drug interactions in our database — the Trandolapril, Verapamil one above is among them. If you take anything else, check it against the full list below.

Moderate 540 Minor 1 No known interaction 2,289 (incl. Trandolapril, Verapamil)
Taking anything else?

Check Another of Your Medications Against Noni

Covers the 2,830 medications we’ve checked against Noni. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Trandolapril, Verapamil

This page covers Noni only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trandolapril, Verapamil page lists 304 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 11 major · 250 moderate · 43 minor.

From our pharmacist’s overview on the Trandolapril, Verapamil page

“This is one of the supplement lists I would want a patient to read closely, not skim. Tarka combines trandolapril and verapamil to lower blood pressure, and most of these interactions pull on that same lever, either dropping pressure further than intended or working against the medicine altogether.”

Reviewed by 2 · Jul 18, 2026

Open the Trandolapril, Verapamil interaction page

One more smart check

Taking Noni as Part of a Dietary Supplement Product? Check It for Interactions

We hold 727 real supplement products containing Noni, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Noni. Your product may carry other ingredients that interact with Trandolapril, Verapamil too, on top of Noni — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Noni and Trandolapril, Verapamil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Noni
Top 25%

#288 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trandolapril, Verapamil
Top 25%

#517 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Noni

What is Noni?

Noni
  • General wellness and energy
  • Inflammation and joint pain
  • Immune support
  • High blood pressure
  • Skin and wound care
  • Digestive complaints

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake is generally well tolerated, there are rare reports of liver problems, and it should be avoided in pregnancy and breastfeeding. Talk with your pharmacist or doctor before using it, especially if you have kidney or liver disease.

Read the full Noni monograph & all interactions
Keep checking

Other Drugs & Noni

Browse every other medication we’ve checked against Noni — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
540Moderate
1Minor
2,288No known interaction
540 Moderate 1 Minor 2,288 No interaction
Moderate

540 interactions

Showing 60 of 540 moderate interactions — see all 540 on the Noni page.

Minor

1 interaction

No interaction 2,288 drugs checked — show the list

We also checked Noni against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,288 medications checked with no known interaction — see the full Noni list.

See the full Noni interactions page
See every supplement checked against Trandolapril, Verapamil, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Noni monograph › Uses, safety, and every drug interaction in one place Trandolapril, Verapamil supplement interactions › Every supplement checked against Trandolapril, Verapamil, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Noni and Trandolapril, Verapamil Together: Common Questions

Can you take Noni with Trandolapril, Verapamil?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Noni and Trandolapril, Verapamil?
Trandolapril, Verapamil belongs to more than one drug category, and Noni interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Noni and Trandolapril, Verapamil interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.