Drug & supplement interaction

Stereospermum + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Stereospermum and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.

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Interaction report

Stereospermum and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Stereospermum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stereospermum safety at a glance

Stereospermum overall Not established Human safety data are very limited, so its overall safety is not well established.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Stereospermum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tasimelteon

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tasimelteon is filed under 5 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, cns depressants. Stereospermum has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Tasimelteon’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Stereospermum Does Interact With Other Medications

Stereospermum has 86 moderate known drug interactions in our database — Tasimelteon isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Tasimelteon)
Taking anything else?

Check Another of Your Medications Against Stereospermum

Covers the 2,830 medications we’ve checked against Stereospermum. Pick one to open its full report.

What to actually watch for

What Tasimelteon’s Own FDA Label Lists

This is not an interaction — none of it involves Stereospermum. These are the most notable effects listed in the ADVERSE REACTIONS section of Tasimelteon’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Vivid dreams or nightmares mentioned in 8.5% of FDA reports for Tasimelteon
  • Trouble sleeping mentioned in 19.8% of FDA reports for Tasimelteon
  • Headache mentioned in 6.7% of FDA reports for Tasimelteon

From the ADVERSE REACTIONS section of the FDA label for Tasimelteon. Read the label on DailyMed › Where a percentage is shown, it is the share of 5,765 voluntary FDA FAERS reports for Tasimelteon that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Stereospermum’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Stereospermum side to compare — that is a limit of the record, not a statement that Stereospermum has no side effects.

How to take them

Some Tasimelteon Products Have a Food Rule — Stereospermum Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Stereospermum included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Stereospermum to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Stereospermum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

One more smart check

Taking Stereospermum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 34 real supplement products containing Stereospermum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stereospermum. Even though Stereospermum itself has no known interaction with Tasimelteon, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stereospermum and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stereospermum
Steady interest

#823 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#2,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stereospermum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Stereospermum and Tasimelteon records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stereospermum

What is Stereospermum?

  • Fever
  • Inflammation and pain
  • Digestive complaints
  • Respiratory issues
  • General tonic in Ayurveda

Stereospermum is a tree used in traditional Ayurvedic medicine, most notably as one of the herbs in the classic 'Dashamula' (ten-root) formula. There is very little high-quality human research to confirm its benefits, so its uses remain largely traditional. If you are considering it, talk with a pharmacist or doctor first, especially if you are pregnant, breastfeeding, or taking other medicines.

Stereospermum suaveolens · Bignoniaceae · Root bark, stem bark, leaves, and flowers · Powder (churna), decoction, capsules, and as part of traditional Ayurvedic herbal blends

An interaction check asks whether these two react with each other — it does not ask whether Stereospermum is a good idea for someone in your situation. Here is what our Stereospermum record says about it on its own.

Stereospermum: dosing

There is no well-established standardized dose for Stereospermum. Traditional preparations vary, and it is often used as part of multi-herb formulas rather than alone.If you choose to use a product that contains it, follow the directions on the product label and do not exceed the recommended amount.

From our Stereospermum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stereospermum monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Stereospermum

Browse every other medication we’ve checked against Stereospermum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Stereospermum page.

No interaction 2,743 drugs checked — show the list

We also checked Stereospermum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Stereospermum list.

See the full Stereospermum interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Stereospermum References

The 2 references that drive our Stereospermum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Balasubramanian T, Lal MS, Sarkar M, Chatterjee TK. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. J Diet Suppl 2009;6(3):227-51.
  2. Balsubramanian T, Senthilkumar GP, Karthikeyan M, Chatterjee TK. Protective effect of ethyl acetate fraction of Stereospermum suaveolens against hepatic oxidative stress in STZ diabetic rats. J Tradit Complement Med 2013;3(3):175-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stereospermum and Tasimelteon Together: Common Questions

Is it safe to take Stereospermum with Tasimelteon?
We do not list a known interaction between Stereospermum and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Stereospermum and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Stereospermum to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Stereospermum and Tasimelteon combination checked?
Interactions in our licensed database are recorded against drug classes. Tasimelteon is filed under 5 classifications, and Stereospermum has documented interactions with 1 drug class — none of Tasimelteon's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Stereospermum interact with any other medications?
Yes. Stereospermum has 86 documented drug interactions in our database — Tasimelteon is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Stereospermum is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stereospermum monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Stereospermum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.