Drug & supplement interaction

Sunflower Oil + Fluconazole

Fluconazole brand names: Diflucan, Diflucan Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sunflower Oil and Fluconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sunflower Oil and Fluconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluconazole and Sunflower Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sunflower Oil safety at a glance

Sunflower Oil overall Generally safe Sunflower oil is widely used as a food and is generally safe for most people in normal dietary amounts.
Pregnancy Likely Safe When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil wh... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil wh... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluconazole and Sunflower Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fluconazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fluconazole is filed under 7 classifications — including antifungals, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Sunflower Oil has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Fluconazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sunflower Oil Does Interact With Other Medications

Sunflower Oil has 86 moderate known drug interactions in our database — Fluconazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Fluconazole)
Taking anything else?

Check Another of Your Medications Against Sunflower Oil

Covers the 2,830 medications we’ve checked against Sunflower Oil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sunflower Oil and Fluconazole May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Sunflower Oil

    “Orally, sunflower oil can cause an allergic reaction in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs. However, the protein content of sunflower oil is very low. In one case report, an allergic response to sunflower oil did not occur despite presenting with severe allergy and anaphylaxis to sunflower seed.”

    Sunflower Oil · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 108140. An J. Anaphylaxis to sunflower seed with tolerance to sunflower oil: A case report. Medicina (Kaunas) 2021;57(7):661. PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

Reported for Sunflower Oil but not commonly for Fluconazole: an allergic reaction.

Effects for Fluconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Sunflower Oil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sunflower Oil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of sunflower oil when used in amounts greater than those found in food.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Sunflower Oil or Fluconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sunflower Oil or Fluconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fluconazole

This page covers Sunflower Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluconazole page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 54 moderate · 23 minor.

From our pharmacist’s overview on the Fluconazole page

“Fluconazole (Diflucan) treats fungal infections, and I would pair it with supplements carefully. Nearly half of the 81 ingredients with an interaction on file, 38 of them, put extra strain on the liver, which is already busy processing the antifungal.”

Reviewed by 2 · Jul 18, 2026

Open the Fluconazole interaction page

One more smart check

Taking Sunflower Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 314 real supplement products containing Sunflower Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sunflower Oil. Even though Sunflower Oil itself has no known interaction with Fluconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sunflower Oil and Fluconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sunflower Oil
Top 25%

#337 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluconazole
Top 25%

#581 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sunflower Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sunflower Oil and Fluconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sunflower Oil

What is Sunflower Oil?

  • Cooking and frying
  • Skin moisturizing
  • Hair and scalp care
  • Source of vitamin E and unsaturated fats
  • Massage and carrier oil
  • Heart-healthy fat substitute

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, and it is also used on the skin, but evidence for treating any specific medical condition is limited. If you have a known allergy to sunflower seeds or ragweed-family plants, use caution.

Helianthus annuus · Asteraceae · Oil pressed from the seeds · Cooking oil, topical oil, skin and hair products, soft-gel capsules, ingredient in salad dressings and margarine

An interaction check asks whether these two react with each other — it does not ask whether Sunflower Oil is a good idea for someone in your situation. Here is what our Sunflower Oil record says about it on its own.

Sunflower Oil: dosing

There is no standard medicinal dose of sunflower oil. As a food, it is simply used in cooking and baking like other vegetable oils, in the amounts called for in recipes.For skin or hair use, people typically apply a small amount as needed.

From our Sunflower Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sunflower Oil monograph & all interactions
Medication

About Fluconazole

What Is Fluconazole Used For?

Brand names: Diflucan, Diflucan Injection

Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Most-Reported Side Effects for Fluconazole

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,205 reports
Nausea 3,813 reports
Diarrhea 3,614 reports
Fatigue 3,266 reports
Headache 2,930 reports
See full Fluconazole drug information
Keep checking

Other Drugs & Sunflower Oil

Browse every other medication we’ve checked against Sunflower Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Sunflower Oil page.

No interaction 2,743 drugs checked — show the list

We also checked Sunflower Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Sunflower Oil list.

See the full Sunflower Oil interactions page
See every supplement checked against Fluconazole, ranked by severity
Evidence & sources

Sunflower Oil References

The 2 references that drive our Sunflower Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. An J. Anaphylaxis to sunflower seed with tolerance to sunflower oil: A case report. Medicina (Kaunas) 2021;57(7):661. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sunflower Oil and Fluconazole Together: Common Questions

Is it safe to take Sunflower Oil with Fluconazole?
We do not list a known interaction between Sunflower Oil and Fluconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sunflower Oil and Fluconazole have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Sunflower Oil and Fluconazole combination checked?
Interactions in our licensed database are recorded against drug classes. Fluconazole is filed under 7 classifications, and Sunflower Oil has documented interactions with 1 drug class — none of Fluconazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sunflower Oil interact with any other medications?
Yes. Sunflower Oil has 86 documented drug interactions in our database — Fluconazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fluconazole interact with any supplements?
Yes. Fluconazole has documented interactions with 81 supplements in our database — Sunflower Oil is not one of them. The Fluconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sunflower Oil monograph Uses, safety profile, and every drug interaction in one place Fluconazole drug information The full plain-English guide to this medication Fluconazole supplement interactions Every supplement checked against Fluconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fluconazole and Sunflower Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.