Drug & supplement interaction

Sunflower Oil + Sitagliptin, Metformin

Sitagliptin, Metformin brand name: Zituvimet.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Sunflower Oil has a moderate interaction with Sitagliptin, Metformin. Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Sunflower Oil and Sitagliptin, Metformin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Sitagliptin, Metformin

Sitagliptin, Metformin falls under ANTIDIABETES DRUGS — the group Sunflower Oil interacts with.

Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
A diet using sunflower oil as a fat source can cause increased fasting blood glucose levels in patients with type 2 diabetes. Dose adjustments to diabetes medications might be necessary.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the practical takeaway with your Zituvimet (which combines sitagliptin and metformin to lower blood sugar). Some lower-quality research suggests that using sunflower oil as your main dietary fat source might nudge fasting blood sugar upward in people with type 2 diabetes. In plain terms, that could make your medication work a little less effectively, so you might notice your morning numbers creeping higher than usual.

I want to be honest that this evidence is on the weaker side and mostly theoretical, so I wouldn't panic. Normal cooking amounts of sunflower oil are unlikely to throw things off. If you're using it heavily or checking your glucose at home, keep an eye on your readings and mention any upward trend to your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Sunflower Oil Also Interacts With Other Medications

Sunflower Oil has 85 moderate known drug interactions in our database — the Sitagliptin, Metformin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Sitagliptin, Metformin)
Taking anything else?

Check Another of Your Medications Against Sunflower Oil

Covers the 2,830 medications we’ve checked against Sunflower Oil. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Sitagliptin, Metformin

This page covers Sunflower Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sitagliptin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

Open the Sitagliptin, Metformin interaction page

One more smart check

Taking Sunflower Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 314 real supplement products containing Sunflower Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sunflower Oil. Your product may carry other ingredients that interact with Sitagliptin, Metformin too, on top of Sunflower Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sunflower Oil and Sitagliptin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sunflower Oil
Top half

#369 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sitagliptin, Metformin
Steady interest

#2,380 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Sunflower Oil

What is Sunflower Oil?

  • Cooking and frying
  • Skin moisturizing
  • Hair and scalp care
  • Source of vitamin E and unsaturated fats
  • Massage and carrier oil
  • Heart-healthy fat substitute

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, and it is also used on the skin, but evidence for treating any specific medical condition is limited. If you have a known allergy to sunflower seeds or ragweed-family plants, use caution.

Read the full Sunflower Oil monograph & all interactions
Keep checking

Other Drugs & Sunflower Oil

Browse every other medication we’ve checked against Sunflower Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Sunflower Oil page.

No interaction 2,744 drugs checked — show the list

We also checked Sunflower Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Sunflower Oil list.

See the full Sunflower Oil interactions page
See every supplement checked against Sitagliptin, Metformin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sunflower Oil monograph › Uses, safety, and every drug interaction in one place Sitagliptin, Metformin supplement interactions › Every supplement checked against Sitagliptin, Metformin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sunflower Oil and Sitagliptin, Metformin Together: Common Questions

Can you take Sunflower Oil with Sitagliptin, Metformin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Sunflower Oil and Sitagliptin, Metformin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sitagliptin, Metformin and Sunflower Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.