Drug & supplement interaction

Tangerine + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tangerine and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Tangerine and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Tangerine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tangerine safety at a glance

Tangerine overall Generally safe Tangerine fruit is generally safe when eaten as food.
Pregnancy Use caution The fruit is fine as food, but concentrated extracts and essential oil should be used with caution and medical advice.
Breastfeeding Use caution Eating the fruit is fine, but safety of concentrated supplements or oils is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Tangerine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Imiquimod

Interactions in our licensed database are recorded against drug classes, not just single drug names. Imiquimod is filed under a single classification — topical drugs. Tangerine has documented interactions with 2 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (minor) and midazolam (versed) (minor) — and none of Imiquimod’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tangerine Does Interact With Other Medications

Tangerine has 643 minor known drug interactions in our database — Imiquimod isn’t one of them. If you take anything else, check it against the full list below.

Minor 643 No known interaction 2,187 (incl. Imiquimod)
Taking anything else?

Check Another of Your Medications Against Tangerine

Covers the 2,830 medications we’ve checked against Tangerine. Pick one to open its full report.

What to actually watch for

What Tangerine Itself Has Been Linked To

This is not an interaction — nothing below involves Imiquimod. It is the side-effect record for Tangerine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tangerine, this list is the first place to look.

  • A skin rash Additional detail

    “Orally, very few adverse effects have been reported with the medicinal use of tangerine. However, a thorough evaluation of safety outcomes has not been conducted.

    Topically, contact dermatitis has been associated with tangerine essential oil.”

    Tangerine · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 28610. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

    “According to one case report, the essential oil of tangerine in a fragrance has been associated with contact dermatitis.”

    Tangerine · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 28610. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Tangerine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Imiquimod’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Imiquimod column appears here.

Overlapping uses

What Imiquimod Is Prescribed For, and What Tangerine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Imiquimod is a prescription medicine with approved uses on its FDA label. Tangerine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Imiquimod is prescribed for: Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older. It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Tangerine has been studied for:

  • Cancer studied, not established Tangerine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Tangerine for cancer

    Observational research has found that daily intake of oranges and/or tangerines is associated with a reduced odds of developing nasopharyngeal carcinoma when compared with consuming oranges and/or tangerines less than once a week.

    1 source cited
    1. 28608. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Imiquimod on your own; if you are taking Tangerine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Tangerine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Tangerine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 705 real supplement products containing Tangerine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tangerine. Even though Tangerine itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tangerine and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tangerine
Top 25%

#253 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imiquimod
Top half

#1,174 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tangerine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tangerine and Imiquimod records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tangerine

What is Tangerine?

  • Source of vitamin C
  • Digestive support
  • Aromatherapy and relaxation
  • Cough and phlegm (traditional)
  • Skin and flavoring uses

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and aromatherapy, strong human evidence for specific health benefits beyond basic nutrition is limited. Enjoying tangerines as part of a balanced diet is generally safe for most people.

Citrus reticulata · Rutaceae · Fruit, peel, and essential oil · Fresh fruit, juice, dried peel, essential oil, capsules, extracts

An interaction check asks whether these two react with each other — it does not ask whether Tangerine is a good idea for someone in your situation. Here is what our Tangerine record says about it on its own.

Tangerine: dosing

There is no official or standardized medicinal dose for tangerine. As a food, you can simply enjoy it the way you would any fruit.For peel, extracts, essential oil, or capsule products, there is no established dose proven safe and effective for any condition. Essential oils are for external or aromatherapy use only unless a professional advises otherwise.

From our Tangerine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tangerine monograph & all interactions
Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports
Fatigue 179 reports
Nausea 114 reports
Influenza like illness 102 reports
Application site erythema 100 reports
See full Imiquimod Topical drug information
Keep checking

Other Drugs & Tangerine

Browse every other medication we’ve checked against Tangerine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
643Minor
2,186No known interaction
643 Minor 2,186 No interaction
Minor

643 interactions

Showing 60 of 643 minor interactions — see all 643 on the Tangerine page.

No interaction 2,186 drugs checked — show the list

We also checked Tangerine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Tangerine list.

See the full Tangerine interactions page
See every supplement checked against Imiquimod, ranked by severity
Evidence & sources

Tangerine References

The 3 references that drive our Tangerine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tangerine and Imiquimod Together: Common Questions

Is it safe to take Tangerine with Imiquimod?
We do not list a known interaction between Tangerine and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Tangerine and Imiquimod used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Tangerine in each. That is a conversation for your prescriber, especially if Imiquimod is being adjusted to a target.
How was the Tangerine and Imiquimod combination checked?
Interactions in our licensed database are recorded against drug classes. Imiquimod is filed under 1 classification, and Tangerine has documented interactions with 2 drug classes — none of Imiquimod's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tangerine interact with any other medications?
Yes. Tangerine has 643 documented drug interactions in our database — Imiquimod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Imiquimod interact with any supplements?
Yes. Imiquimod has documented interactions with 3 supplements in our database — Tangerine is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tangerine monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Tangerine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.