Drug & supplement interaction

Trichopus Zeylanicus + Istradefylline

Istradefylline brand name: Nourianz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Trichopus Zeylanicus and Istradefylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Trichopus Zeylanicus and Istradefylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Istradefylline and Trichopus Zeylanicus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Trichopus Zeylanicus safety at a glance

Trichopus Zeylanic... overall Not established Human safety data are very limited, so use cautiously and under professional guidance.
Pregnancy Avoid Safety has not been established, so avoid use during pregnancy.
Breastfeeding Avoid No reliable safety data exist, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Istradefylline and Trichopus Zeylanicus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Istradefylline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Istradefylline is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Trichopus Zeylanicus has documented interactions with 1 drug class — the most serious being immunosuppressants (moderate) — and none of Istradefylline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Trichopus Zeylanicus Does Interact With Other Medications

Trichopus Zeylanicus has 121 moderate known drug interactions in our database — Istradefylline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Istradefylline)
Taking anything else?

Check Another of Your Medications Against Trichopus Zeylanicus

Covers the 2,830 medications we’ve checked against Trichopus Zeylanicus. Pick one to open its full report.

What to actually watch for

What Istradefylline’s Own FDA Label Lists

This is not an interaction — none of it involves Trichopus Zeylanicus. These are the most notable effects listed in the ADVERSE REACTIONS section of Istradefylline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on
  • High blood sugar Worth acting on
  • A change in sex drive
  • Reduced appetite
  • Trouble sleeping
  • Constipation
  • Dizziness
  • Diarrhea
  • A skin rash
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Istradefylline. Read the label on DailyMed › Trichopus Zeylanicus’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Trichopus Zeylanicus side to compare — that is a limit of the record, not a statement that Trichopus Zeylanicus has no side effects.

Everything else you take

See Every Supplement That Interacts With Istradefylline

This page covers Trichopus Zeylanicus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Istradefylline page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Istradefylline page

“Istradefylline (Nourianz) is added to levodopa to trim the daily 'off' time of Parkinson's disease, and its supplement list deserves genuine care. Most of the 138 ingredients here can change how the liver enzyme CYP3A4 handles the drug, so blood levels may drift too high or too low.”

Reviewed by 2 · Jul 18, 2026

Open the Istradefylline interaction page

One more smart check

Taking Trichopus Zeylanicus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Trichopus Zeylanicus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Trichopus Zeylanicus. Even though Trichopus Zeylanicus itself has no known interaction with Istradefylline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Trichopus Zeylanicus and Istradefylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Trichopus Zeylanicus
Top half

#677 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Istradefylline
Top half

#865 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Trichopus Zeylanicus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Trichopus Zeylanicus and Istradefylline records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Trichopus Zeylanicus

What is Trichopus Zeylanicus?

  • Fatigue and energy
  • Physical stamina
  • Stress and adaptation
  • General tonic/well-being
  • Immune support

Trichopus zeylanicus is a tropical herb traditionally used as a tonic to boost energy and resist stress, but human evidence is very limited and mostly based on animal or laboratory studies. Because little is known about its safety, talk with a pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Trichopus zeylanicus · Dioscoreaceae · Leaves (and sometimes whole plant) · Capsules, powder, extracts, teas

An interaction check asks whether these two react with each other — it does not ask whether Trichopus Zeylanicus is a good idea for someone in your situation. Here is what our Trichopus Zeylanicus record says about it on its own.

Trichopus Zeylanicus: dosing

There is no established standard dose for Trichopus zeylanicus. Because reliable human studies are lacking, no safe and effective amount has been confirmed.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Trichopus Zeylanicus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Trichopus Zeylanicus monograph & all interactions
Medication

About Istradefylline

What Is Istradefylline Used For?

Brand name: Nourianz

Istradefylline (sold as Nourianz) is an add-on treatment for adults with Parkinson’s disease. It is used with levodopa/carbidopa in people who have “off” episodes.

“Off” episodes are times when Parkinson’s symptoms return or get worse between doses of levodopa.

See full Istradefylline drug information
Keep checking

Other Drugs & Trichopus Zeylanicus

Browse every other medication we’ve checked against Trichopus Zeylanicus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Trichopus Zeylanicus page.

No interaction 2,708 drugs checked — show the list

We also checked Trichopus Zeylanicus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Trichopus Zeylanicus list.

See the full Trichopus Zeylanicus interactions page
See every supplement checked against Istradefylline, ranked by severity
Evidence & sources

Trichopus Zeylanicus References

The 1 references that drive our Trichopus Zeylanicus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singh B, Chandan BK, Sharma N, et al. Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II). Phytomedicine 2005;12:468-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Trichopus Zeylanicus and Istradefylline Together: Common Questions

Is it safe to take Trichopus Zeylanicus with Istradefylline?
We do not list a known interaction between Trichopus Zeylanicus and Istradefylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Trichopus Zeylanicus and Istradefylline combination checked?
Interactions in our licensed database are recorded against drug classes. Istradefylline is filed under 2 classifications, and Trichopus Zeylanicus has documented interactions with 1 drug class — none of Istradefylline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Trichopus Zeylanicus interact with any other medications?
Yes. Trichopus Zeylanicus has 121 documented drug interactions in our database — Istradefylline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Istradefylline interact with any supplements?
Yes. Istradefylline has documented interactions with 138 supplements in our database — Trichopus Zeylanicus is not one of them. The Istradefylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Trichopus Zeylanicus monograph Uses, safety profile, and every drug interaction in one place Istradefylline drug information The full plain-English guide to this medication Istradefylline supplement interactions Every supplement checked against Istradefylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Istradefylline and Trichopus Zeylanicus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.