Drug & supplement interaction

Trichopus Zeylanicus + Teplizumab-mzwv

Teplizumab-mzwv brand name: Tzield.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Trichopus Zeylanicus has a moderate interaction with Teplizumab-mzwv. Theoretically, Trichopus zeylanicus might reduce the effects of immunosuppressants.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Trichopus Zeylanicus and Teplizumab-mzwv

Here is the interaction we found between these two, with the evidence behind it.

Moderate

IMMUNOSUPPRESSANTS

Why this applies to Teplizumab-mzwv

Teplizumab-mzwv falls under IMMUNOSUPPRESSANTS — the group Trichopus Zeylanicus interacts with.

Theoretically, Trichopus zeylanicus might reduce the effects of immunosuppressants. Animal research suggests that Trichopus zeylanicus might have immunostimulant effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Tzield (teplizumab). This is an infused medicine that works by calming down the part of your immune system that attacks the insulin-making cells in your pancreas, with the goal of delaying type 1 diabetes. So its whole job is to quiet immune activity.

Trichopus zeylanicus is being studied as something that might do the opposite, gently revving up immune activity. In theory, that could work against Tzield and chip away at the benefit you're hoping to get. I want to be honest though: this idea comes only from test-tube and animal studies, not from people, so it's a soft, theoretical concern rather than a proven problem. Since Tzield is a serious medicine given in a short course, I'd skip the herb and run it by your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Singh B, Chandan BK, Sharma N, et al. Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II). Phytomedicine 2005;12:468-81. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Trichopus Zeylanicus Also Interacts With Other Medications

Trichopus Zeylanicus has 120 moderate known drug interactions in our database — the Teplizumab-mzwv one above is one of them. If you take anything else, check it against the full list below.

Moderate 120 No known interaction 2,710 (incl. Teplizumab-mzwv)
Taking anything else?

Check Another of Your Medications Against Trichopus Zeylanicus

Covers the 2,830 medications we’ve checked against Trichopus Zeylanicus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Teplizumab-mzwv

This page covers Trichopus Zeylanicus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Teplizumab-mzwv page lists 89 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Active Hexose Correlated Compound (ahcc) (moderate) and Alfalfa (moderate).

By severity: 3 major · 85 moderate · 1 minor.

From our pharmacist’s overview on the Teplizumab-mzwv page

“Siberian cocklebur is the single riskiest item here for anyone on teplizumab-mzwv (Tzield), the infusion given to delay the onset of type 1 diabetes. That herb has caused liver injury and outright liver failure on its own, and 38 of the 89 interacting ingredients on this page share that liver theme, including beer and wine, which carry…”

Reviewed by 2 · Jul 18, 2026

Open the Teplizumab-mzwv interaction page

One more smart check

Taking Trichopus Zeylanicus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Trichopus Zeylanicus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Trichopus Zeylanicus. Your product may carry other ingredients that interact with Teplizumab-mzwv too, on top of Trichopus Zeylanicus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Trichopus Zeylanicus and Teplizumab-mzwv Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Trichopus Zeylanicus
Steady interest

#943 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Teplizumab-mzwv
Top 10%

#201 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Trichopus Zeylanicus

What is Trichopus Zeylanicus?

  • Fatigue and energy
  • Physical stamina
  • Stress and adaptation
  • General tonic/well-being
  • Immune support

Trichopus zeylanicus is a tropical herb traditionally used as a tonic to boost energy and resist stress, but human evidence is very limited and mostly based on animal or laboratory studies. Because little is known about its safety, talk with a pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Read the full Trichopus Zeylanicus monograph & all interactions
Medication

About Teplizumab-mzwv injection

What Is Teplizumab-mzwv injection Used For?

Brand name: Tzield

Tzield is used to delay the onset of Stage 3 type 1 diabetes (T1D) in adults and children aged 1 year and older who already have Stage 2 T1D — meaning their immune system is attacking insulin-producing cells, but they don't yet have overt high blood sugar symptoms.

Tzield is also used to slow the loss of the body's own insulin production in children and teenagers aged 8 to 17 years who have recently been diagnosed with Stage 3 T1D. This second use is approved under accelerated approval, meaning continued approval depends on results from ongoing confirmatory studies.

See full Teplizumab-mzwv injection drug information
Keep checking

Other Drugs & Trichopus Zeylanicus

Browse every other medication we’ve checked against Trichopus Zeylanicus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
120Moderate
0Minor
2,709No known interaction
120 Moderate 2,709 No interaction
Moderate

120 interactions

Showing 60 of 120 moderate interactions — see all 120 on the Trichopus Zeylanicus page.

No interaction 2,709 drugs checked — show the list

We also checked Trichopus Zeylanicus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,709 medications checked with no known interaction — see the full Trichopus Zeylanicus list.

See the full Trichopus Zeylanicus interactions page
See every supplement checked against Teplizumab-mzwv, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Trichopus Zeylanicus monograph › Uses, safety, and every drug interaction in one place Teplizumab-mzwv supplement interactions › Every supplement checked against Teplizumab-mzwv, ranked by severity Teplizumab-mzwv injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Trichopus Zeylanicus and Teplizumab-mzwv Together: Common Questions

Can you take Trichopus Zeylanicus with Teplizumab-mzwv?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Trichopus Zeylanicus and Teplizumab-mzwv interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Teplizumab-mzwv and Trichopus Zeylanicus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.