Drug & supplement interaction

Wine + Thioguanine

Thioguanine brand names: Thioguanine, Tabloid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Wine and Thioguanine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wine and Thioguanine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Thioguanine and Wine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wine safety at a glance

Wine overall Use caution Wine contains alcohol, which can harm health and become habit-forming even in moderate amounts.
Pregnancy Likely Unsafe When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developm... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcoho... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Thioguanine and Wine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Thioguanine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Thioguanine is filed under a single classification — oral drugs. Wine has documented interactions with 37 drug classes — the most serious being aspirin (major), cisapride (propulsid) (major) and cns depressants (major) — and none of Thioguanine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wine Does Interact With Other Medications

Wine has 658 major, 270 moderate known drug interactions in our database — Thioguanine isn’t one of them. If you take anything else, check it against the full list below.

Major 658 Moderate 270 No known interaction 1,902 (incl. Thioguanine)
Taking anything else?

Check Another of Your Medications Against Wine

Covers the 2,830 medications we’ve checked against Wine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wine and Thioguanine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Wine

    “Orally, chronic heavy alcohol ingestion of three or more drinks daily is associated with an increased risk of all-cause mortality, atrial fibrillation, cardiac myopathy, hypertension, ischemic stroke, and myocardial infarction (MI). Consumption of any amount of alcohol can increase the risk of hemorrhagic stroke.”

    Wine · Natural Medicines adverse-effect record, reported in atrial fibrillation.

    6 sources cited
    1. 2261. Pearson TA. Alcohol and heart disease. Circulation 1996;94:3023-5. PubMed
    2. 6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
    3. 6892. Goldberg I, Mosca L, Piano MR, Fisher EA. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the America
    4. 8102. Thadhani R, Camargo CA, Stampfer MJ, et al. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med 2002;162:569-74. PubMed
    5. 9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
    6. 33984. Seiler, C. [Alcohol, the heart and cardiovascular system]. Ther Umsch. 2000;57(4):200-204.

    Thioguanine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioguanine. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Wine

    “Orally, chronic heavy alcohol ingestion (three or more drinks daily) can lead to cirrhosis and hepatotoxicity.”

    Wine · Natural Medicines adverse-effect record, reported in cirrhosis.

    2 sources cited
    1. 6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
    2. 9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

    Thioguanine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioguanine. Read the label on DailyMed ›

  • Vomiting / Nausea reported in 4.1% of FDA reports for Thioguanine Additional detail

    Wine

    “Orally, wine can cause a variety of side effects which depend on the amount of alcohol ingested and can vary among individuals. Some common side effects include abdominal pain, diarrhea, indigestion, nausea, and vomiting.. Chronic alcohol use is also associated with pancreatitis.”

    Wine · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
    2. 8972. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
    3. 9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
    4. 34013. Bode, C. and Bode, J. C. Alcohol's role in gastrointestinal tract disorders. Alcohol Health Res World 1997;21(1):76-83.
    5. 34031. Pehl, C., Wendl, B., and Pfeiffer, A. White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Aliment.Pharmacol Ther 6-1-2006;23(11):1581-1586. PubMed

    Thioguanine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioguanine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Wine but not commonly for Thioguanine: a heart attack, dependence or withdrawal symptoms, an irregular heartbeat and mood changes or irritability.

Effects for Thioguanine come from the ADVERSE REACTIONS section of its FDA label; effects for Wine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,099 voluntary FDA FAERS reports for Thioguanine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wine in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developmental and behavioral dysfunction in infants and children exposed to alcohol in utero; avoid using.

Lactation Likely Unsafe

When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcohol also seems to reduce milk production; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Thioguanine Is Prescribed For, and What Wine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Thioguanine is a prescription medicine with approved uses on its FDA label. Wine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Thioguanine is prescribed for: Tabloid brand thioguanine is used for remission induction and remission consolidation in acute nonlymphocytic leukemias. That means getting the leukemia into remission and then helping keep it there. It is not recommended for maintenance or other long-term continuous treatment because of a high risk of liver toxicity. It is not effective for chronic lymphocytic leukemia, Hodgkin’s lymphoma, multiple myeloma, or solid tumors.

Wine has been studied for:

  • Cancer studied, not established Wine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Wine for cancer

    It is unclear if wine consumption is beneficial for preventing cancer or cancer-related mortality. The available evidence suggests variable effects depending on cancer type.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Thioguanine on your own; if you are taking Wine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Thioguanine

This page covers Wine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Thioguanine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Thioguanine page

“With thioguanine (Tabloid), a chemotherapy pill used mainly for leukemias, the supplement question is an absorption question. Each interaction here can change how much of a swallowed dose reaches the blood, and with a cancer drug that deserves genuine caution, because a partly absorbed dose can undercut treatment.”

Reviewed by 2 · Jul 18, 2026

Open the Thioguanine interaction page

One more smart check

Taking Wine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Wine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wine. Even though Wine itself has no known interaction with Thioguanine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wine and Thioguanine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wine
Top half

#415 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Thioguanine
Top half

#1,391 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Wine and Thioguanine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wine

What is Wine?

  • Social and relaxation use
  • Heart health (popular belief)
  • Antioxidant intake
  • Aiding digestion (traditional use)
  • Culinary flavoring

Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine. Despite popular claims about heart benefits, the alcohol it contains carries real health risks, and no amount of drinking can be recommended to improve health. If you drink, do so in moderation, and avoid alcohol entirely during pregnancy or if you have certain medical conditions.

Fermented grapes (or other fruit) · Red wine, white wine, rosé, sparkling wine, fortified wine

An interaction check asks whether these two react with each other — it does not ask whether Wine is a good idea for someone in your situation. Here is what our Wine record says about it on its own.

Wine: dosing

There is no medicinal or supplement "dose" for wine, and no amount is recommended to improve health. If a person chooses to drink, public health guidelines generally define moderate drinking as up to one standard drink per day for women and up to two for men, with a standard drink being about 5 ounces of wine.Less is always better when it comes to alcohol, and not drinking at all is the safest choice.

From our Wine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wine monograph & all interactions
Medication

About Thioguanine

What Is Thioguanine Used For?

Brand names: Thioguanine, Tabloid

Tabloid brand thioguanine is used for remission induction and remission consolidation in acute nonlymphocytic leukemias. That means getting the leukemia into remission and then helping keep it there.

It is not recommended for maintenance or other long-term continuous treatment because of a high risk of liver toxicity. It is not effective for chronic lymphocytic leukemia, Hodgkin’s lymphoma, multiple myeloma, or solid tumors.

Most-Reported Side Effects for Thioguanine

From FAERS, the FDA’s public side-effect reporting system (2,099 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 486 reports
Haematotoxicity 138 reports
Neutropenia 134 reports
Fever 134 reports
Thrombocytopenia 100 reports
See full Thioguanine drug information
Keep checking

Other Drugs & Wine

Browse every other medication we’ve checked against Wine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

658Major
270Moderate
0Minor
1,901No known interaction
658 Major 270 Moderate 1,901 No interaction
Major

658 interactions

Showing 60 of 658 major interactions — see all 658 on the Wine page.

Moderate

270 interactions

Showing 60 of 270 moderate interactions — see all 270 on the Wine page.

No interaction 1,901 drugs checked — show the list

We also checked Wine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,901 medications checked with no known interaction — see the full Wine list.

See the full Wine interactions page
See every supplement checked against Thioguanine, ranked by severity
Evidence & sources

Wine References

The 73 references that drive our Wine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Hart CL, Smith GD, Hole DJ, Hawthorne VM. Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. BMJ 1999;318:1725-9. PubMed
  3. Offman EM, Freeman DJ, Dresser GK, et al. Cisapride interaction with grapefruit juice and red wine. Clin Pharmacol Ther 2000;67:110 (abstract PI-83).
  4. Tsunoda SM, Christians U, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) metabolites. Clin Pharmacol Ther 2000;67:150 (abstract PIII-35).
  5. Tsunoda SM, Harris RZ, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) Pharmacokinetics. Clin Pharmacol Ther 1998;65:159 (abstract PII-51). DOI
  6. Pearson TA. Alcohol and heart disease. Circulation 1996;94:3023-5. PubMed
  7. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
  8. Stampfer MJ, Colditz GA, Willett WC, et al. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 1988;319:267-73. PubMed
  9. Vally H, de Klerk N, Thompson PJ. Alcoholic drinks: important triggers for asthma. J Allergy Clin Immunol 2000;105:462-7. PubMed
  10. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
  11. Goldberg I, Mosca L, Piano MR, Fisher EA. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the America
  12. Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-37.
  13. Dufour MC. If you drink alcoholic beverages do so in moderation: what does this mean? J Nutr 2001;131:552S-61S. PubMed
  14. Thadhani R, Camargo CA, Stampfer MJ, et al. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med 2002;162:569-74. PubMed
  15. Mukamal KJ, Longstreth WT, Mittleman MA. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke 2001;32:1939-46. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wine and Thioguanine Together: Common Questions

Is it safe to take Wine with Thioguanine?
We do not list a known interaction between Wine and Thioguanine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wine and Thioguanine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Wine and Thioguanine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Wine in each. That is a conversation for your prescriber, especially if Thioguanine is being adjusted to a target.
How was the Wine and Thioguanine combination checked?
Interactions in our licensed database are recorded against drug classes. Thioguanine is filed under 1 classification, and Wine has documented interactions with 37 drug classes — none of Thioguanine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wine interact with any other medications?
Yes. Wine has 928 documented drug interactions in our database — Thioguanine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Thioguanine interact with any supplements?
Yes. Thioguanine has documented interactions with 17 supplements in our database — Wine is not one of them. The Thioguanine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wine monograph Uses, safety profile, and every drug interaction in one place Thioguanine drug information The full plain-English guide to this medication Thioguanine supplement interactions Every supplement checked against Thioguanine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 73 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Thioguanine and Wine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.