What Supplements Interact with Acetaminophen, Codeine, Methocarbamol?
Acetaminophen, Codeine, Methocarbamol brand names: Acetaminophen, Codeine, Methocarbamol, Robaxacet 8. Every interaction below applies to the brands too.
Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy
What is this page for?
One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Codeine, Methocarbamol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.
This page covers supplement interactions only — to check Acetaminophen, Codeine, Methocarbamol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy
243 supplements and herbal ingredients have interactions with Acetaminophen, Codeine, Methocarbamol on file in the HelloPharmacist interaction database — 10 rated major, 193 moderate, and 40 minor. The most serious involve Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal.
Our assessment: with 10 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Codeine, Methocarbamol.
Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.
This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓
Acetaminophen, Codeine, Methocarbamol: Top Interactions at a Glance
The Acetaminophen, Codeine, Methocarbamol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.
Showing the 12 highest-ranked of 243 interacting ingredients — plus 1,209 more checked with no known interaction. See the complete ranked list.
The Most-Checked Acetaminophen, Codeine, Methocarbamol Combinations Today
The Acetaminophen, Codeine, Methocarbamol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full interaction Minor Likelihood Possible Bitter Orange + Acetaminophen, Codeine, MethocarbamoliTheoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
Read the full interaction Moderate Likelihood Possible Baikal Skullcap + Acetaminophen, Codeine, MethocarbamoliTheoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full interaction Minor Likelihood Unlikely Gamma-aminobutyric Acid (gaba) + Acetaminophen, Codeine, MethocarbamoliTheoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full interaction Moderate Likelihood Possible Hesperidin + Acetaminophen, Codeine, MethocarbamoliTheoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full interaction Moderate Likelihood Possible Jamaican Dogwood + Acetaminophen, Codeine, MethocarbamoliJamaican dogwood may potentiate sedative effects.
Read the full interactionEvery Supplement Checked Against Acetaminophen, Codeine, Methocarbamol
All 1,452 ingredients in our database, ranked by severity — 243 with a Acetaminophen, Codeine, Methocarbamol interaction on file and 1,209 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.
Looking for an interaction with a specific supplement product? Search products instead ↓
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Beer Likely
What it is: Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health suppl...
Concomitant use may increase sedative and other adverse effects.
Read the full Beer + Acetaminophen, Codeine, Methocarbamol interactionSiberian Cocklebur Likely
What it is: Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and al...
Siberian cocklebur can adversely affect the kidney.
Read the full Siberian Cocklebur + Acetaminophen, Codeine, Methocarbamol interactionWine Likely
What it is: Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine.
Concomitant use may increase sedative and other adverse effects.
Read the full Wine + Acetaminophen, Codeine, Methocarbamol interaction1,4-butanediolOne Comma Four, one Four Bdo, one Four Bee, +1 more Probable
What it is: 1,4-butanediol is a toxic industrial chemical, not a safe dietary supplement.
Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.
Read the full 1,4-butanediol + Acetaminophen, Codeine, Methocarbamol interactionActivated CharcoalActivated Carbon, animal Charcoal, carbo Vegetabilis, +13 more Probable
What it is: Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some...
Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full Activated Charcoal + Acetaminophen, Codeine, Methocarbamol interactionGamma-hydroxybutyrate (ghb) Probable
What it is: GHB (gamma-hydroxybutyrate) is a powerful central nervous system depressant that is NOT a safe dietary supplement.
GHB may increase the risk of serious CNS and respiratory depression.
Read the full Gamma-hydroxybutyrate (ghb) + Acetaminophen, Codeine, Methocarbamol interactionKavaPiper Methysticum, ava Pepper, ava Root, +20 more Probable
What it is: Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety.
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava + Acetaminophen, Codeine, Methocarbamol interactionL-tryptophanL-triptofano, l-trypt, l-tryptophane, +1 more Probable
What it is: L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood.
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Codeine, Methocarbamol interactionProcaine Probable
What it is: Procaine is a synthetic local anesthetic (best known by the brand name Novocaine) used by doctors and dentists to numb tissue.
Intravenous use of procaine hydrochloride is contraindicated.
Read the full Procaine + Acetaminophen, Codeine, Methocarbamol interactionAsarabaccaAsarum Europaeum, asara, asari Herba, +12 more Possible
What it is: Asarabacca is a European woodland plant traditionally used to clear the nose, cause sweating, or trigger vomiting, but it is rarely used tod...
Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.
Read the full Asarabacca + Acetaminophen, Codeine, Methocarbamol interactionAyahuascaAppane, ayahoasca, caapi, +19 more Probable
What it is: Ayahuasca is a powerful psychoactive brew that combines a DMT-containing plant with a vine that allows the DMT to take effect, causing inten...
Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.
Read the full Ayahuasca + Acetaminophen, Codeine, Methocarbamol interactionBrussels Sprout Probable
What it is: Brussels sprouts are a nutritious cruciferous vegetable rich in fiber, vitamin C, vitamin K, and plant compounds called glucosinolates.
A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.
Read the full Brussels Sprout + Acetaminophen, Codeine, Methocarbamol interactionCabbageBrassica Oleracea, cabbage Leaf, chou, +13 more Probable
What it is: Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast en...
Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
Read the full Cabbage + Acetaminophen, Codeine, Methocarbamol interactionCannabidiol (cbd) Probable
What it is: CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorder...
Cannabidiol may increase levels of drugs metabolized by CYP1A2.
Read the full Cannabidiol (cbd) + Acetaminophen, Codeine, Methocarbamol interactionCoffee CharcoalCafé Arabica, café Carbonisé, café Robusta, +5 more Probable
What it is: Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarr...
Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Read the full Coffee Charcoal + Acetaminophen, Codeine, Methocarbamol interactionEuropean MandrakeMandragora Officinarum, alraunwurzel, mandragora, +7 more Probable
What it is: European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reli...
Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake.
Read the full European Mandrake + Acetaminophen, Codeine, Methocarbamol interactionEvodia Probable
What it is: Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain.
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Read the full Evodia + Acetaminophen, Codeine, Methocarbamol interactionGarlicAllium Sativum, aged Black Garlic Extract, aged Garlic Extract, +16 more Probable
What it is: Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects...
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic + Acetaminophen, Codeine, Methocarbamol interactionGlucomannanGlucomanano, glucomannane, konjac, +1 more Probable
What it is: Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipati...
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Glucomannan + Acetaminophen, Codeine, Methocarbamol interactionGoldensealHydrastis Canadensis, chinese Goldenseal, eye Balm, +14 more Probable
What it is: Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects.
Goldenseal might increase serum levels of drugs metabolized by CYP2D6.
Read the full Goldenseal + Acetaminophen, Codeine, Methocarbamol interactionLithiumCarbonate De Lithium, citrate De Lithium, lithium Aspartate, +8 more Probable
What it is: Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment...
Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Read the full Lithium + Acetaminophen, Codeine, Methocarbamol interactionMagnesiumChelated Magnesium, dimagnesium Malate, epsom Salts, +10 more Probable
What it is: Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful...
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium + Acetaminophen, Codeine, Methocarbamol interactionMelatoninN-acetyl-5-methoxytryptamine Probable
What it is: Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with...
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Codeine, Methocarbamol interactionResveratrolExtrait De Vin, extrait De Vin Rouge, kojo-kon, +16 more Probable
What it is: Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant supp...
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol + Acetaminophen, Codeine, Methocarbamol interactionSyrian Rue Probable
What it is: Syrian Rue (Peganum harmala) is a traditional plant whose seeds contain potent compounds called harmala alkaloids, including MAO-inhibiting...
Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Syrian Rue + Acetaminophen, Codeine, Methocarbamol interactionYerba MansaAnemopsis Californica, anemopsis De Californie, lizard's Tail, +3 more Probable
What it is: Yerba mansa is a traditional Southwestern and Mexican medicinal plant used for sore throats, skin problems, and infections.
Theoretically, concomitant use might cause additive or prolonged sedative effects.
Read the full Yerba Mansa + Acetaminophen, Codeine, Methocarbamol interaction1,3-dmaaDmaa, dimethylamylamine Possible
What it is: DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to seriou...
1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.
Read the full 1,3-dmaa + Acetaminophen, Codeine, Methocarbamol interaction5-htp5 Hydroxy-tryptophan, 5 Hydroxy-tryptophane, 5-hydroxytryptophan, +9 more Possible
What it is: 5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches.
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full 5-htp + Acetaminophen, Codeine, Methocarbamol interactionAcacia RigidulaVachellia Rigidula, acacia Rigidula, acaciopsis Rigidula, +3 more Possible
What it is: Acacia rigidula is a shrub from Texas and Mexico that is marketed in weight-loss and energy supplements.
Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 substrates.
Read the full Acacia Rigidula + Acetaminophen, Codeine, Methocarbamol interactionActive Hexose Correlated Compound (ahcc) Possible
What it is: AHCC is a proprietary mushroom-derived supplement promoted mainly for immune support and to help people tolerate cancer treatment.
Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.
Read the full Active Hexose Correlated Compound (ahcc) + Acetaminophen, Codeine, Methocarbamol interactionAdrafinilAdrafinilum, benzhydryl Sulfinyl Acetyl Hydroxamic Acid, crl-40028, +1 more Possible
What it is: Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug.
Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Adrafinil + Acetaminophen, Codeine, Methocarbamol interactionAdrueCyperus Articulatus, chintul, cyperus, +5 more Possible
What it is: Adrue (Cyperus articulatus) is a sedge whose rhizome has long been used in traditional medicine for nausea and other stomach complaints, and...
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Adrue + Acetaminophen, Codeine, Methocarbamol interactionAfrican Wild Potato Possible
What it is: African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflamm...
In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).
Read the full African Wild Potato + Acetaminophen, Codeine, Methocarbamol interactionAlbizia JulibrissinAlbizia Julibrissin, arbre De Sois, federbaum, +16 more Possible
What it is: Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming th...
Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice.
Read the full Albizia Julibrissin + Acetaminophen, Codeine, Methocarbamol interactionAnisePimpinella Anisum, anis, anís, +14 more Possible
What it is: Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs.
Theoretically, anise oil might increase the effects and adverse effects of codeine.
Read the full Anise + Acetaminophen, Codeine, Methocarbamol interactionAristolochiaAristolochia Auricularia, birthwort, guan Mu Tong, +15 more Possible
What it is: Aristolochia contains aristolochic acid, a potent toxin linked to severe kidney damage and cancer, and it is not safe to take.
Aristolochia is nephrotoxic.
Read the full Aristolochia + Acetaminophen, Codeine, Methocarbamol interactionAshitabaAngelica Keiskei, angelica, ashitaba Du Japon, +6 more Possible
What it is: Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benef...
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Ashitaba + Acetaminophen, Codeine, Methocarbamol interactionAshwagandhaWithania Somnifera, ajagandha, amangura, +17 more Possible
What it is: Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, thoug...
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha + Acetaminophen, Codeine, Methocarbamol interactionBacopaBacopa Monnieri, andri, brahmi, +11 more Possible
What it is: Bacopa is an Ayurvedic herb most often used for memory and thinking.
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa + Acetaminophen, Codeine, Methocarbamol interactionBaikal SkullcapScutellaria Baicalensis, baikal Scullcap, baikal Skullcap Root, +16 more Possible
What it is: Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baica...
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Baikal Skullcap + Acetaminophen, Codeine, Methocarbamol interactionBay LeafLaurus Nobilis, bay, bay Laurel, +17 more Possible
What it is: Bay leaf is a common culinary herb that is safe in the small amounts used in cooking.
Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.
Read the full Bay Leaf + Acetaminophen, Codeine, Methocarbamol interactionBerberineAlcaloïde De Berbérine, berberina, berbérine, +5 more Possible
What it is: Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of res...
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine + Acetaminophen, Codeine, Methocarbamol interactionBeta-methylphenethylamine (bmpea) Possible
What it is: Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and spo...
Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full Beta-methylphenethylamine (bmpea) + Acetaminophen, Codeine, Methocarbamol interactionBilberryVaccinium Myrtillus, airelle, arándano, +16 more Possible
What it is: Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for...
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry + Acetaminophen, Codeine, Methocarbamol interactionBiofeedback Possible
What it is: Biofeedback is a mind-body technique, not an herb or supplement.
There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.
Read the full Biofeedback + Acetaminophen, Codeine, Methocarbamol interactionBitter AlmondPrunus Amygdalus, almendra Amarga, almendro Amargo, +13 more Possible
What it is: Bitter almond is a variety of almond that contains amygdalin, a compound the body converts into cyanide, making it potentially poisonous.
Theoretically, bitter almond oil may have additive effects with other CNS depressants.
Read the full Bitter Almond + Acetaminophen, Codeine, Methocarbamol interactionBlack CohoshActaea Racemosa, baie D'actée, baneberry, +10 more Possible
What it is: Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from s...
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Black Cohosh + Acetaminophen, Codeine, Methocarbamol interactionBlack Hoof MushroomPhellinus Linteus, black Hoof Fungus, mesima, +5 more Possible
What it is: Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support.
Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Black Hoof Mushroom + Acetaminophen, Codeine, Methocarbamol interactionBlack PepperPiper Nigrum, black Peppercorn, extrait De Poivre, +23 more Possible
What it is: Black pepper is a common kitchen spice that is generally safe in the amounts used in food.
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Black Pepper + Acetaminophen, Codeine, Methocarbamol interactionBlack SeedNigella Sativa, black Caraway, black Cumin, +18 more Possible
What it is: Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure...
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed + Acetaminophen, Codeine, Methocarbamol interactionBoldoPeumus Boldus, boldine, boldo Folium, +4 more Possible
What it is: Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is ver...
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Codeine, Methocarbamol interactionBoswellia SerrataBoswellia Serrata, arbre à Oliban Indien, boswella, +10 more Possible
What it is: Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation.
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata + Acetaminophen, Codeine, Methocarbamol interactionBreadfruit Possible
What it is: Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high bloo...
Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).
Read the full Breadfruit + Acetaminophen, Codeine, Methocarbamol interactionBroccoli Possible
What it is: Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific int...
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Acetaminophen, Codeine, Methocarbamol interactionBuchuAgathosma Betulina, anysboegoe, barasmae Folium, +12 more Possible
What it is: Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic.
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Codeine, Methocarbamol interactionBulbine Natalensis Possible
What it is: Bulbine natalensis is a South African plant marketed mainly as a testosterone-boosting and libido supplement, but the human evidence is esse...
Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Bulbine Natalensis + Acetaminophen, Codeine, Methocarbamol interactionCajeput OilMelaleuca Leucadendra, aceite De Cajeput, cajeputi Aetheroleum, +10 more Possible
What it is: Cajeput oil is an aromatic essential oil traditionally used for aches, congestion, and minor skin complaints, but solid human evidence for t...
Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.
Read the full Cajeput Oil + Acetaminophen, Codeine, Methocarbamol interactionCalamusAcorus Calamus, acore Calame, acore Odorant, +20 more Possible
What it is: Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complain...
Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.
Read the full Calamus + Acetaminophen, Codeine, Methocarbamol interactionCalcium D-glucarate Possible
What it is: Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and help...
Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
Read the full Calcium D-glucarate + Acetaminophen, Codeine, Methocarbamol interactionCalifornia PoppyEschscholzia Californica, amapola De California, pavot D'amérique, +4 more Possible
What it is: California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs.
Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Read the full California Poppy + Acetaminophen, Codeine, Methocarbamol interactionCamphor Possible
What it is: Camphor is a strong-smelling compound from the camphor tree (or made synthetically) that is used in many topical rub-on products for muscle...
Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.
Read the full Camphor + Acetaminophen, Codeine, Methocarbamol interactionCannabichromene (cbc)Cannabichrome, pentylcannabichromene, cannabinochromene Possible
What it is: Cannabichromene (CBC) is a non-intoxicating cannabinoid found in the cannabis plant that is being studied for possible pain, anti-inflammato...
Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.
Read the full Cannabichromene (cbc) + Acetaminophen, Codeine, Methocarbamol interactionCannabinol (cbn) Possible
What it is: Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limit...
Theoretically, cannabinol might increase the levels and clinical effects of CYP2E1 substrates.
Read the full Cannabinol (cbn) + Acetaminophen, Codeine, Methocarbamol interactionCannabisCannabis Sativa, anashca, banji, +25 more Possible
What it is: Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not).
Theoretically, cannabis might have additive effects if used with other CNS depressants.
Read the full Cannabis + Acetaminophen, Codeine, Methocarbamol interactionCarawayCarum Carvi, alcaravea, anis Canadien, +20 more Possible
What it is: Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion.
Theoretically, caraway might increase the effects and adverse effects of CNS depressants.
Read the full Caraway + Acetaminophen, Codeine, Methocarbamol interactionCassia CinnamonCinnamomum Aromaticum, bastard Cinnamon, chinese Cinnamon, +1 more Possible
What it is: Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar suppor...
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia Cinnamon + Acetaminophen, Codeine, Methocarbamol interactionCatechuBlack Catechu, acacia Catechu: Acacia à Cachou, acacia Catechu Heartwood Extract, +17 more Possible
What it is: Catechu is an astringent extract made from the heartwood of the Acacia (Senegalia) catechu tree, used traditionally for mouth sores, sore th...
Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.
Read the full Catechu + Acetaminophen, Codeine, Methocarbamol interactionCatnipNepeta Cataria, cataire, catmint, +8 more Possible
What it is: Catnip is a mint-family herb most often used as a calming tea for sleep, anxiety, and minor digestive upset, but solid human research suppor...
Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Read the full Catnip + Acetaminophen, Codeine, Methocarbamol interactionCauliflower Possible
What it is: Cauliflower is a nutritious cruciferous vegetable that provides vitamin C, fiber, and plant compounds called glucosinolates.
Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabbage, can increase cytochrome P450 1A2 (CYP1A2) activity by 14% to 27%.
Read the full Cauliflower + Acetaminophen, Codeine, Methocarbamol interactionCeleryApium Graveolens, ache Des Marais, ajamoda, +13 more Possible
What it is: Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint d...
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery + Acetaminophen, Codeine, Methocarbamol interactionCeylon Leadwort Possible
What it is: Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin pr...
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Ceylon Leadwort + Acetaminophen, Codeine, Methocarbamol interactionChanca PiedraPhyllanthus Niruri, amli, arranca-pedras, +16 more Possible
What it is: Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health.
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Chanca Piedra + Acetaminophen, Codeine, Methocarbamol interactionChaparralLarrea Divaricata, creosote Bush, créosotier, +4 more Possible
What it is: Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition.
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Codeine, Methocarbamol interactionCinchonaCinchona Calisaya, arbol De La Quina, bois Aux Fièvres, +14 more Possible
What it is: Cinchona bark is the natural source of quinine and has been used for centuries to treat malaria and fever, but the bark itself is not standa...
Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.
Read the full Cinchona + Acetaminophen, Codeine, Methocarbamol interactionCloveSyzygium Aromaticum, bourgeon Floral De Clou De Girofle, bouton Floral De Clou De Girofle, +12 more Possible
What it is: Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to it...
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove + Acetaminophen, Codeine, Methocarbamol interactionCnidiumCnidium Monnieri, cnidii Fructus, cnidii Monnieri Fructus, +10 more Possible
What it is: Cnidium is the dried fruit of an Asian plant long used in traditional Chinese medicine, mostly for skin problems and sexual health.
In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.
Read the full Cnidium + Acetaminophen, Codeine, Methocarbamol interactionComfreySymphytum Officinale, ass Ear, beinwellwurzel, +15 more Possible
What it is: Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit fo...
Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Comfrey + Acetaminophen, Codeine, Methocarbamol interactionCorianderCoriandrum Sativum, coriander Essential Oil, coriandre, +5 more Possible
What it is: Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints...
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Coriander + Acetaminophen, Codeine, Methocarbamol interactionCorn PoppyPapaver Rhoeas, amapola, common Poppy, +18 more Possible
What it is: Corn poppy is a red-flowered plant traditionally used in teas and syrups for cough, sleep, and mild pain.
Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.
Read the full Corn Poppy + Acetaminophen, Codeine, Methocarbamol interactionCorydalis Yanhusuo Possible
What it is: Corydalis yanhusuo is a traditional Chinese herb used mainly for pain.
Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.
Read the full Corydalis Yanhusuo + Acetaminophen, Codeine, Methocarbamol interactionDandelionTaraxacum Officinale, blowball, cankerwort, +17 more Possible
What it is: Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid.
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Codeine, Methocarbamol interactionDanshenSalvia Bowleyana, ch'ih Shen, chinese Red Sage, +15 more Possible
What it is: Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems.
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Danshen + Acetaminophen, Codeine, Methocarbamol interactionDelta-9-tetrahydrocannabinol (thc)Bho, black Glass, budder, +9 more Possible
What it is: THC is the main mind-altering compound in cannabis and is best known for causing a 'high.' A prescription form (dronabinol) is approved for...
Theoretically, THC might have additive effects if used with other CNS depressants.
Read the full Delta-9-tetrahydrocannabinol (thc) + Acetaminophen, Codeine, Methocarbamol interactionDendrobium Possible
What it is: Dendrobium is a group of orchids long used in traditional Chinese medicine, often to moisten the body and as a general tonic.
The dendrobium constituent dendrobine is reported to have convulsant effects.
Read the full Dendrobium + Acetaminophen, Codeine, Methocarbamol interactionDiosmin Possible
What it is: Diosmin is a citrus-derived flavonoid most often used for vein-related problems such as chronic venous insufficiency and hemorrhoids, and it...
Theoretically, diosmin might inhibit the metabolism of CYP2E1 substrates.
Read the full Diosmin + Acetaminophen, Codeine, Methocarbamol interactionEchinaceaAmerican Cone Flower, black Sampson, black Susans, +7 more Possible
What it is: Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears sm...
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea + Acetaminophen, Codeine, Methocarbamol interactionElecampaneAlant, aunée, aunée Officinale, +17 more Possible
What it is: Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion.
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane + Acetaminophen, Codeine, Methocarbamol interactionEleutheroEleutherococcus Senticosus, acanthopanax Obovatus, ciwujia Root, +13 more Possible
What it is: Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress.
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Codeine, Methocarbamol interactionEnglish IvyHedera Helix, common Ivy, gum Ivy, +9 more Possible
What it is: English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredie...
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy + Acetaminophen, Codeine, Methocarbamol interactionEphedraEphedra Distachya, belcho, cao Mahuang, +13 more Possible
What it is: Ephedra (ma huang) contains powerful stimulants like ephedrine that affect the heart and nervous system.
Theoretically, ephedra might decrease levels of drugs metabolized by CYP1A2.
Read the full Ephedra + Acetaminophen, Codeine, Methocarbamol interactionEpistane Possible
What it is: Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been s...
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Codeine, Methocarbamol interactionEucalyptusEucalyptus Globulus, blue Gum, blue Mallee, +13 more Possible
What it is: Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion.
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus + Acetaminophen, Codeine, Methocarbamol interactionEuropean BarberryBerberis Vulgaris, agracejo, barberry, +15 more Possible
What it is: European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolat...
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full European Barberry + Acetaminophen, Codeine, Methocarbamol interactionFalse UnicornChamaelirium Luteum, alétris, blazing Star, +9 more Possible
What it is: False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concern...
In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.
Read the full False Unicorn + Acetaminophen, Codeine, Methocarbamol interactionFever BarkAlstonia Constricta, alstonia Bark, australian Febrifuge, +10 more Possible
What it is: Fever bark is the bark of the Australian tree Alstonia constricta, used in traditional medicine for fever, diarrhea, and infections.
Theoretically, fever bark might increase the levels and clinical effects of CYP2D6 substrates.
Read the full Fever Bark + Acetaminophen, Codeine, Methocarbamol interactionFeverfewTanacetum Parthenium, altamisa, bachelor's Buttons, +13 more Possible
What it is: Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occ...
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew + Acetaminophen, Codeine, Methocarbamol interactionFo-ti Possible
What it is: Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair.
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Fo-ti + Acetaminophen, Codeine, Methocarbamol interactionGalphimia GlaucaGalphimia Glauca, calderona Amarilla, flor Estrella, +2 more Possible
What it is: Galphimia glauca is a shrub from Mexico and Central America that has been studied mainly for anxiety, with some small clinical trials sugges...
Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.
Read the full Galphimia Glauca + Acetaminophen, Codeine, Methocarbamol interactionGamma Butyrolactone (gbl)2-3 Dihydro Furanone Possible
What it is: Gamma butyrolactone (GBL) is a toxic industrial solvent, not a dietary supplement, and the body converts it into GHB, a powerful and dangero...
Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.
Read the full Gamma Butyrolactone (gbl) + Acetaminophen, Codeine, Methocarbamol interactionGarciniaGarcinia Gummi-gutta, acide Hydroxycitrique, ahc, +11 more Possible
What it is: Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control.
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia + Acetaminophen, Codeine, Methocarbamol interactionGerman ChamomileMatricaria Recutita, blue Chamomile, camomèle, +12 more Possible
What it is: German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints.
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full German Chamomile + Acetaminophen, Codeine, Methocarbamol interactionGinkgoGinkgo Biloba, abricot Argenté Japonais, adiantifolia, +13 more Possible
What it is: Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation.
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgo + Acetaminophen, Codeine, Methocarbamol interactionGojiLycium Chinense, lycium Barbarum, barberry Matrimony Vine, +15 more Possible
What it is: Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food.
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Goji + Acetaminophen, Codeine, Methocarbamol interactionGotu KolaCentella Asiatica, asiatic Pennywort, brahma-buti, +12 more Possible
What it is: Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memor...
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
Read the full Gotu Kola + Acetaminophen, Codeine, Methocarbamol interactionGrapeVitis Vinifera, activin, black Grape Raisins, +10 more Possible
What it is: Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support h...
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Read the full Grape + Acetaminophen, Codeine, Methocarbamol interactionGrapefruitCitrus Paradisi Possible
What it is: Grapefruit is a nutritious citrus fruit rich in vitamin C and other nutrients, and it is generally safe to eat.
Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP1A2.
Read the full Grapefruit + Acetaminophen, Codeine, Methocarbamol interactionGreater CelandineChelidonium Majus, bai Qu Cai, celandine, +9 more Possible
What it is: Greater celandine is a traditional herb most often promoted for digestive and gallbladder complaints, but solid human evidence for any use i...
Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.
Read the full Greater Celandine + Acetaminophen, Codeine, Methocarbamol interactionGriffonia SimplicifoliaBandeiraea Simplicifolia Possible
What it is: Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin.
Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.
Read the full Griffonia Simplicifolia + Acetaminophen, Codeine, Methocarbamol interactionGuar GumDietary Fiber, farine De Guar, fibre Alimentaire, +10 more Possible
What it is: Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity.
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Codeine, Methocarbamol interactionGuarumoCecropia Obtusifolia, chancarro, grayumbo, +9 more Possible
What it is: Guarumo (Cecropia obtusifolia) is a tropical tree used in Latin American traditional medicine, most often as a leaf tea for diabetes and hig...
In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle relaxant activity.
Read the full Guarumo + Acetaminophen, Codeine, Methocarbamol interactionGum ArabicAcacia, acacia Gum, arabic Gum, +16 more Possible
What it is: Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplemen...
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Gum Arabic + Acetaminophen, Codeine, Methocarbamol interactionGymnemaGymnema Sylvestre, gimnema, gur-mar, +14 more Possible
What it is: Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue.
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema + Acetaminophen, Codeine, Methocarbamol interactionHemp AgrimonyEupatorium Cannabinum, alpenkraut, cañamazo, +15 more Possible
What it is: Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little relia...
Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).
Read the full Hemp Agrimony + Acetaminophen, Codeine, Methocarbamol interactionHesperidinAlpha-glucosyl Hesperidin, alpha-glucosylhesperidin, bioflavonoid, +8 more Possible
What it is: Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrh...
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin + Acetaminophen, Codeine, Methocarbamol interactionHigenamine Possible
What it is: Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidenc...
Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Higenamine + Acetaminophen, Codeine, Methocarbamol interactionHopsHumulus Lupulus, asperge Sauvage, common Hops, +13 more Possible
What it is: Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very stron...
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Read the full Hops + Acetaminophen, Codeine, Methocarbamol interactionHorny Goat WeedEpimedium Grandiflorum, barrenwort, Épimède, +10 more Possible
What it is: Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence...
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Acetaminophen, Codeine, Methocarbamol interactionHu Zhang Possible
What it is: Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin.
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Hu Zhang + Acetaminophen, Codeine, Methocarbamol interactionIndian SnakerootRauvolfia Serpentina, ajmaline, alseroxylon, +16 more Possible
What it is: Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects...
Theoretically, taking Indian snakeroot might cause additive sedative effects.
Read the full Indian Snakeroot + Acetaminophen, Codeine, Methocarbamol interactionIndole-3-carbinol Possible
What it is: Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement m...
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Codeine, Methocarbamol interactionIpriflavone7-isopropoxyisoflavone, ipriflavona Possible
What it is: Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it relia...
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Codeine, Methocarbamol interactionJackfruitArtocarpus Heterophyllus, arbol Del Pan, baramil, +21 more Possible
What it is: Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants.
Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.
Read the full Jackfruit + Acetaminophen, Codeine, Methocarbamol interactionJamaican Dogwood Possible
What it is: Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking.
Jamaican dogwood may potentiate sedative effects.
Read the full Jamaican Dogwood + Acetaminophen, Codeine, Methocarbamol interactionKhellaAmmi Visnaga, ammi Daucoides, daucus Visnaga, +13 more Possible
What it is: Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels.
Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Khella + Acetaminophen, Codeine, Methocarbamol interactionKratomMitragyna Speciosa, biak-biak, cratom, +16 more Possible
What it is: Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effec...
Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.
Read the full Kratom + Acetaminophen, Codeine, Methocarbamol interactionKudzuPueraria Montana, bidarikand, bilaikanda, +18 more Possible
What it is: Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol in...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Acetaminophen, Codeine, Methocarbamol interactionLemon BalmMelissa Officinalis, balm, balm Mint, +15 more Possible
What it is: Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically f...
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Lemon Balm + Acetaminophen, Codeine, Methocarbamol interactionLemongrassCymbopogon Citratus, abafado, cana Santa, +17 more Possible
What it is: Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil.
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Lemongrass + Acetaminophen, Codeine, Methocarbamol interactionLentinanBeta-glucan Lentinan, lentinane, lentinus Edodes Polysaccharide, +4 more Possible
What it is: Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherap...
Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2D6 (CYP2D6).
Read the full Lentinan + Acetaminophen, Codeine, Methocarbamol interactionLigandrol Possible
What it is: Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement.
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Ligandrol + Acetaminophen, Codeine, Methocarbamol interactionMace Possible
What it is: Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg.
Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedative effects.
Read the full Mace + Acetaminophen, Codeine, Methocarbamol interactionMagnoliaMagnolia Biondii, beaver Tree, bourgeon Floral De Magnolia, +13 more Possible
What it is: Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion.
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia + Acetaminophen, Codeine, Methocarbamol interactionManchurian Thorn Possible
What it is: Manchurian Thorn (Aralia elata) is a thorny shrub or small tree used in traditional East Asian medicine, mainly for blood sugar, joint pain,...
Animal research suggests that high doses of Manchurian thorn can induce liver damage.
Read the full Manchurian Thorn + Acetaminophen, Codeine, Methocarbamol interactionMarsh Labrador TeaRhododendron Tomentosum, james' Tea, lède Des Marais, +13 more Possible
What it is: Marsh Labrador tea is a bog-growing shrub used in folk medicine for coughs, colds, and skin problems, but high-quality human evidence for an...
Marsh Labrador tea can potentiate effects of barbiturates and alcohol.
Read the full Marsh Labrador Tea + Acetaminophen, Codeine, Methocarbamol interactionMethoxylated Flavones Possible
What it is: Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substance...
Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.
Read the full Methoxylated Flavones + Acetaminophen, Codeine, Methocarbamol interactionMilk ThistleSilybum Marianum, artichaut Sauvage, blessed Milk Thistle, +12 more Possible
What it is: Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called s...
Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.
Read the full Milk Thistle + Acetaminophen, Codeine, Methocarbamol interactionMotherwortLeonurus Cardiac, agripalma, agripaume, +16 more Possible
What it is: Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but soli...
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Motherwort + Acetaminophen, Codeine, Methocarbamol interactionMountain AshSorbus Aucuparia, arbre Aux Grives, corbier D'europe, +12 more Possible
What it is: Mountain ash (rowan) is a northern-hemisphere tree whose bright red berries are traditionally cooked into jams, syrups, and teas.
Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.
Read the full Mountain Ash + Acetaminophen, Codeine, Methocarbamol interactionN,n-dmpea Possible
What it is: N,N-DMPEA (N,N-dimethylphenethylamine) is a synthetic relative of phenethylamine sometimes marketed in stimulant or pre-workout supplements.
In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).
Read the full N,n-dmpea + Acetaminophen, Codeine, Methocarbamol interactionNeemAzadirachta Indica, arishta, arishtha, +18 more Possible
What it is: Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes.
Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Neem + Acetaminophen, Codeine, Methocarbamol interactionNiacin3-pyridinecarboxylic Acid, vitamin B3 Possible
What it is: Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countri...
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Codeine, Methocarbamol interactionNoniMorinda Citrifolia, ba Ji Tian, bois Douleur, +17 more Possible
What it is: Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claime...
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Noni + Acetaminophen, Codeine, Methocarbamol interactionNutmegMyristica Fragrans, buah Pala, jaatipatree, +14 more Possible
What it is: Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little so...
Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.
Read the full Nutmeg + Acetaminophen, Codeine, Methocarbamol interactionOnionAllium Cepa, allii Cepae Bulbus, cebolla, +9 more Possible
What it is: Onion is a common food with a long history in traditional medicine, and it contains antioxidants like quercetin and sulfur compounds.
Theoretically, taking onion might increase the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Onion + Acetaminophen, Codeine, Methocarbamol interactionOregon GrapeMahonia Aquifolium, barberry, berberis, +13 more Possible
What it is: Oregon grape is a shrub whose root contains berberine and related compounds.
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape + Acetaminophen, Codeine, Methocarbamol interactionOstarine Possible
What it is: Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not...
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine + Acetaminophen, Codeine, Methocarbamol interactionPadang Cassia Possible
What it is: Padang Cassia is a type of cinnamon (Indonesian or Korintje cinnamon) grown mainly in Indonesia and used widely as a kitchen spice.
There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.
Read the full Padang Cassia + Acetaminophen, Codeine, Methocarbamol interactionPanax GinsengAsian Ginseng, asiatic Ginseng, chinese Ginseng, +12 more Possible
What it is: Panax ginseng is a popular traditional herb used to boost energy, ease stress, and support overall wellness, though scientific evidence is m...
Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.
Read the full Panax Ginseng + Acetaminophen, Codeine, Methocarbamol interactionPanax NotoginsengPanax Notoginseng, field Seven, noto-gin, +15 more Possible
What it is: Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation.
Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Panax Notoginseng + Acetaminophen, Codeine, Methocarbamol interactionParsleyPetroselinum Crispum, common Parsley, garden Parsley, +16 more Possible
What it is: Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C.
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Acetaminophen, Codeine, Methocarbamol interactionPassion FlowerPassiflora Incarnata, apricot Vine, burucuya, +18 more Possible
What it is: Passion flower is a traditional calming herb that many people use for anxiety and sleep.
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passion Flower + Acetaminophen, Codeine, Methocarbamol interactionPennyroyal Possible
What it is: Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to...
Concomitant use of pennyroyal essential oil and acetaminophen might increase the risk of acetaminophen-induced hepatotoxicity.
Read the full Pennyroyal + Acetaminophen, Codeine, Methocarbamol interactionPeonyPaeonia Lactiflora, bai Shao, chi Shao, +17 more Possible
What it is: Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combina...
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Peony + Acetaminophen, Codeine, Methocarbamol interactionPhellodendronPhellodendron Amurense, amur Cork Bark, amur Cork Tree, +7 more Possible
What it is: Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and an...
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron + Acetaminophen, Codeine, Methocarbamol interactionPhenibutBeta-phenyl-gamma-aminobutyric Acid, 4-amino-3-phenylbutyric Acid, b-(aminomethyl)-benzenepropanoic Acid, +7 more Possible
What it is: Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it ca...
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Read the full Phenibut + Acetaminophen, Codeine, Methocarbamol interactionPinellia Ternata Possible
What it is: Pinellia ternata is a tuber used in traditional Chinese medicine, most often for nausea, vomiting, and phlegmy coughs, and almost always as...
Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.
Read the full Pinellia Ternata + Acetaminophen, Codeine, Methocarbamol interactionPomegranatePunica Granatum, anardana, dadim, +14 more Possible
What it is: Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice.
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate + Acetaminophen, Codeine, Methocarbamol interactionPoria Mushroom Possible
What it is: Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid.
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Mushroom + Acetaminophen, Codeine, Methocarbamol interactionPropolisAcide De Cire D'abeille, baume De Propolis, bee Glue, +12 more Possible
What it is: Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies.
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Codeine, Methocarbamol interactionQuercetin7-pentahydroxyflavone, bioflavonoid, bioflavonoid Complex, +9 more Possible
What it is: Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement.
Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Quercetin + Acetaminophen, Codeine, Methocarbamol interactionRauvolfia Vomitoria Possible
What it is: Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for hi...
Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.
Read the full Rauvolfia Vomitoria + Acetaminophen, Codeine, Methocarbamol interactionRauwolscine Possible
What it is: Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout su...
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Codeine, Methocarbamol interactionRed Yeast RiceMonascus Purpureus, cholestin, hong Qu, +19 more Possible
What it is: Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') chole...
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice + Acetaminophen, Codeine, Methocarbamol interactionRhubarbRheum Officinale, chinese Rhubarb, da Huang, +13 more Possible
What it is: Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food.
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Rhubarb + Acetaminophen, Codeine, Methocarbamol interactionRooibosAspalathus Linearis, green Red Bush, infusion Rooibos, +9 more Possible
What it is: Rooibos is a caffeine-free herbal tea from South Africa that is rich in antioxidants and generally considered safe as a beverage.
Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.
Read the full Rooibos + Acetaminophen, Codeine, Methocarbamol interactionSaffronCrocus Sativus, autumn Crocus, azafrán, +16 more Possible
What it is: Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most r...
Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Read the full Saffron + Acetaminophen, Codeine, Methocarbamol interactionSageSalvia Officinalis, broadleaf Sage, common Sage, +14 more Possible
What it is: Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and me...
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Sage + Acetaminophen, Codeine, Methocarbamol interactionSaigon Cinnamon Possible
What it is: Saigon cinnamon is a flavorful spice from a Cinnamomum tree grown mainly in Vietnam, and it is a type of 'cassia' cinnamon.
Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Saigon Cinnamon + Acetaminophen, Codeine, Methocarbamol interactionSassafrasSassafras Albidum, ague Tree, bois De Cannelle, +7 more Possible
What it is: Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole,...
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras + Acetaminophen, Codeine, Methocarbamol interactionSceletium Possible
What it is: Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood.
Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Read the full Sceletium + Acetaminophen, Codeine, Methocarbamol interactionSchizonepeta Possible
What it is: Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and...
Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6.
Read the full Schizonepeta + Acetaminophen, Codeine, Methocarbamol interactionShepherd's PurseCapsella Bursa-pastoris, blind Weed, bolsa Del Pastor, +14 more Possible
What it is: Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human resea...
Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Read the full Shepherd's Purse + Acetaminophen, Codeine, Methocarbamol interactionShiitake Mushroom Possible
What it is: Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people.
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Acetaminophen, Codeine, Methocarbamol interactionSkullcapScutellaria Lateriflora, american Skullcap, blue Pimpernel, +15 more Possible
What it is: American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited.
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap + Acetaminophen, Codeine, Methocarbamol interactionSlippery ElmIndian Elm, moose Elm, olmo Americano, +7 more Possible
What it is: Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and ir...
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Codeine, Methocarbamol interactionSpearmintMentha Spicata, curled Mint, fish Mint, +16 more Possible
What it is: Spearmint is a common culinary mint that is generally safe in food and tea amounts.
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint + Acetaminophen, Codeine, Methocarbamol interactionSt. John's WortHypericum Perforatum, amber Touch-and-heal, barbe De Saint-jean, +13 more Possible
Sulforaphane Possible
What it is: Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflamma...
Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Read the full Sulforaphane + Acetaminophen, Codeine, Methocarbamol interactionSweet AnnieArtemisia Annua, absinthe Sauvage, ajenjo Silvestre, +11 more Possible
What it is: Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs.
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Annie + Acetaminophen, Codeine, Methocarbamol interactionSweet CloverMelilotus Officinalis, angipars, casse Lunettes, +14 more Possible
What it is: Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limit...
Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.
Read the full Sweet Clover + Acetaminophen, Codeine, Methocarbamol interactionTarragonArtemisia Dracunculus, armoise Âcre, dragonne, +8 more Possible
What it is: Tarragon is a flavorful culinary herb that has been used in traditional medicine for digestion, sleep, and other complaints, but solid human...
Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneally at a dose of 1 mL/kg.
Read the full Tarragon + Acetaminophen, Codeine, Methocarbamol interactionTerminaliaTerminalia Arjuna, abhaya, amandier Indien, +19 more Possible
What it is: Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness...
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Terminalia + Acetaminophen, Codeine, Methocarbamol interactionTestolone Possible
What it is: Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Testolone + Acetaminophen, Codeine, Methocarbamol interactionTheacrine Possible
What it is: Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood.
Theoretically, theacrine might alter the effects of CNS depressants.
Read the full Theacrine + Acetaminophen, Codeine, Methocarbamol interactionThuja Possible
What it is: Thuja, also called northern white cedar or arborvitae, is a tree whose leaf and oil have a long history in folk and homeopathic medicine, es...
Thuja products can contains significant amounts of thujone, a neurotoxin.
Read the full Thuja + Acetaminophen, Codeine, Methocarbamol interactionThunder God VineTripterygium Wilfordii, huang-t'eng Ken, lei Gong Teng, +8 more Possible
What it is: Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited...
Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Thunder God Vine + Acetaminophen, Codeine, Methocarbamol interactionTianeptine Possible
What it is: Tianeptine is a prescription antidepressant in some countries, but it is NOT approved by the FDA in the United States and is illegally sold...
Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.
Read the full Tianeptine + Acetaminophen, Codeine, Methocarbamol interactionTinospora Cordifolia Possible
What it is: Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat...
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Tinospora Cordifolia + Acetaminophen, Codeine, Methocarbamol interactionTragacanthAdragante, astragale Adragant, astragale De Marseille, +14 more Possible
What it is: Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the thro...
Theoretically, tragacanth might alter absorption of oral drugs.
Read the full Tragacanth + Acetaminophen, Codeine, Methocarbamol interactionTree Turmeric Possible
What it is: Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content.
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Tree Turmeric + Acetaminophen, Codeine, Methocarbamol interactionTurmericCurcuma Longa, curcuma, curcumae Longa, +17 more Possible
What it is: Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain.
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Acetaminophen, Codeine, Methocarbamol interactionUva UrsiArctostaphylos Uva-ursi, arberry, arbousier, +16 more Possible
What it is: Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have anti...
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi + Acetaminophen, Codeine, Methocarbamol interactionValerianValeriana Officinalis, all-heal, amantilla, +10 more Possible
What it is: Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves.
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Acetaminophen, Codeine, Methocarbamol interactionVitamin A Possible
What it is: Vitamin A is an essential nutrient important for vision, skin, immune function, and growth.
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full Vitamin A + Acetaminophen, Codeine, Methocarbamol interactionWheatgrassTriticum Aestivum, agropyre, blé En Herbe, +7 more Possible
What it is: Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and pl...
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheatgrass + Acetaminophen, Codeine, Methocarbamol interactionWhite Pepper Possible
What it is: White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice.
In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).
Read the full White Pepper + Acetaminophen, Codeine, Methocarbamol interactionWild LettuceLactuca Virosa, acrid Lettuce, allubbyne, +13 more Possible
What it is: Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited.
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce + Acetaminophen, Codeine, Methocarbamol interactionWinter Cherry Possible
What it is: Winter Cherry is another name for ashwagandha (Withania somnifera), an herb long used in Ayurvedic medicine, most often for stress, sleep, a...
In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).
Read the full Winter Cherry + Acetaminophen, Codeine, Methocarbamol interactionYin ChenArmoise à Balais, armoise Capillaire, artemisia Officinalis, +11 more Possible
What it is: Yin Chen is a traditional Chinese medicine herb used mainly for liver and gallbladder complaints and jaundice.
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin Chen + Acetaminophen, Codeine, Methocarbamol interactionYohimbePausinystalia Yohimbe, 11-hydroxy Yohimbine, coryanthe Yohimbe, +7 more Possible
What it is: Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac.
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe + Acetaminophen, Codeine, Methocarbamol interactionZizyphusZiziphus Jujuba, anèbe, annab, +20 more Possible
What it is: Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion.
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Zizyphus + Acetaminophen, Codeine, Methocarbamol interactionGreen TeaCamellia Sinensis, green Sencha Tea, green Tea Extract, +17 more Unlikely
What it is: Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people.
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Green Tea + Acetaminophen, Codeine, Methocarbamol interactionLavenderLavandula Angustifolia, alhucema, common Lavender, +14 more Unlikely
What it is: Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for...
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Codeine, Methocarbamol interactionThyroid Extract Likely
What it is: Thyroid extract supplements are made from dried animal thyroid gland and may contain real thyroid hormones (T3 and T4), but the amounts in o...
Food and medications can interfere with thyroid hormone absorption.
Read the full Thyroid Extract + Acetaminophen, Codeine, Methocarbamol interactionHibiscus SabdariffaHibiscus Sabdariffa, agua De Jamaica, ambashthaki, +16 more Probable
What it is: Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood...
Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.
Read the full Hibiscus Sabdariffa + Acetaminophen, Codeine, Methocarbamol interactionVitamin C Probable
What it is: Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements.
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Codeine, Methocarbamol interaction1,3-dmba Possible
What it is: 1,3-DMBA is a synthetic stimulant chemically similar to the banned stimulant DMAA, and it is not a proven or safe dietary ingredient.
Theoretically, 1,3-DMBA might modestly increase the levels of CYP2D6 substrates.
Read the full 1,3-dmba + Acetaminophen, Codeine, Methocarbamol interactionAgarAgar-agar, agarose, agarose Gel, +17 more Possible
What it is: Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber.
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Codeine, Methocarbamol interactionAlginAlginate, alginate De Calcium, alginate De Magnésium, +12 more Possible
What it is: Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines.
Theoretically, algin can alter the absorption of oral drugs.
Read the full Algin + Acetaminophen, Codeine, Methocarbamol interactionAloeAloe Vera, aloe Capensis, aloe Gel, +18 more Possible
What it is: Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help.
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe + Acetaminophen, Codeine, Methocarbamol interactionAtractylodesAtractylodes Lancea, amk, atr, +9 more Possible
What it is: Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue,...
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Atractylodes + Acetaminophen, Codeine, Methocarbamol interactionBaelAegle Marmelos, arbre De Bael, bael Tree, +16 more Possible
What it is: Bael is a fruit-bearing tree long used in traditional Indian (Ayurvedic) medicine, mostly for digestive problems like diarrhea and indigesti...
Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.
Read the full Bael + Acetaminophen, Codeine, Methocarbamol interactionBeetBeta Vulgaris, beet Greens, beet Juice, +19 more Possible
What it is: Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in...
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beet + Acetaminophen, Codeine, Methocarbamol interactionBitter OrangeCitrus Aurantium, aurantii Fructus, aurantium, +17 more Possible
What it is: Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements.
Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
Read the full Bitter Orange + Acetaminophen, Codeine, Methocarbamol interactionBlack PsylliumAfrican Plantain, brown Psyllium, dietary Fiber, +16 more Possible
What it is: Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive...
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Black Psyllium + Acetaminophen, Codeine, Methocarbamol interactionBlond PsylliumPlantago Ovata, balle De Psyllium, blond Plantago, +14 more Possible
What it is: Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements.
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Blond Psyllium + Acetaminophen, Codeine, Methocarbamol interactionBroccoli Sprout Possible
What it is: Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammat...
Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Sprout + Acetaminophen, Codeine, Methocarbamol interactionCalea Zacatechichi Possible
What it is: Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive compla...
Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Read the full Calea Zacatechichi + Acetaminophen, Codeine, Methocarbamol interactionCarobCeratonia Siliqua, algarrobo, carob Flour, +16 more Possible
What it is: Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum...
Theoretically, carob might also impair the absorption of oral drugs.
Read the full Carob + Acetaminophen, Codeine, Methocarbamol interactionEurycoma LongifoliaAkar Pasak Bumi, ali's Umbrella, ali's Walking Stick, +17 more Possible
What it is: Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some...
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia + Acetaminophen, Codeine, Methocarbamol interactionFucus VesiculosusBlack Tang, bladder Fucus, bladder Wrack, +14 more Possible
What it is: Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin.
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
Read the full Fucus Vesiculosus + Acetaminophen, Codeine, Methocarbamol interactionGingerZingiber Officinale, african Ginger, ardraka, +21 more Possible
What it is: Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nause...
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Codeine, Methocarbamol interactionGlucosamine Possible
What it is: Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, espe...
Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Read the full Glucosamine + Acetaminophen, Codeine, Methocarbamol interactionHempCannabis Sativa, cheungsam, fiber Hemp, +14 more Possible
What it is: Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generall...
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp + Acetaminophen, Codeine, Methocarbamol interactionHordenineAnhalinine Possible
What it is: Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid hu...
Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.
Read the full Hordenine + Acetaminophen, Codeine, Methocarbamol interactionKaraya GumBassora Tragacanth, goma Karaya, gomme Karaya, +14 more Possible
What it is: Karaya gum is a natural plant gum from the Sterculia tree that is mostly used as a bulk-forming laxative and as a thickener or adhesive in f...
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.
Read the full Karaya Gum + Acetaminophen, Codeine, Methocarbamol interactionLicoriceGlycyrrhiza Echinate, alcacuz, bois Doux, +17 more Possible
What it is: Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most...
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Licorice + Acetaminophen, Codeine, Methocarbamol interactionMarshmallowAlthaea Officinalis, altea, alteia, +16 more Possible
What it is: Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sor...
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Codeine, Methocarbamol interactionMoringaMoringa Oleifera Possible
What it is: Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition...
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Moringa + Acetaminophen, Codeine, Methocarbamol interactionPeppermintMentha X Piperita, black Peppermint, brandy Mint, +12 more Possible
What it is: Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms.
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint + Acetaminophen, Codeine, Methocarbamol interactionPuravive Possible
What it is: Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no pub...
Puravive contains Panax ginseng.
Read the full Puravive + Acetaminophen, Codeine, Methocarbamol interactionRhodiolaRhodiola Rosea, arctic Root, golden Root, +12 more Possible
What it is: Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress.
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Codeine, Methocarbamol interactionXanthan GumBacterial Polysaccharide, corn Sugar Gum, goma Xantana, +7 more Possible
What it is: Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing diffic...
Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.
Read the full Xanthan Gum + Acetaminophen, Codeine, Methocarbamol interactionAsian Water PlantainAlisma Plantago-aquatica, dong Fang Ze Xie, jilgyeongitaegsa, +6 more Unlikely
What it is: Asian water plantain (Ze Xie) is a rhizome long used in traditional Chinese medicine, mainly as a diuretic and for fluid retention.
Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does not cause harm to the body.
Read the full Asian Water Plantain + Acetaminophen, Codeine, Methocarbamol interactionCalendulaCalendula Officinalis, caléndula, calendule, +13 more Unlikely
What it is: Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound...
Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Read the full Calendula + Acetaminophen, Codeine, Methocarbamol interactionChrysin Unlikely
What it is: Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies hav...
Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
Read the full Chrysin + Acetaminophen, Codeine, Methocarbamol interactionDiindolylmethaneDim Unlikely
What it is: Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone b...
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full Diindolylmethane + Acetaminophen, Codeine, Methocarbamol interactionGamma-aminobutyric Acid (gaba)Acide Bêta-phényl-gamma-amino-butyrique, acide Gamma-aminobutyrique, Ácido Gama-aminobutríco, +3 more Unlikely
What it is: GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety,...
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Codeine, Methocarbamol interactionHumann Superbeets Heart Chews Unlikely
What it is: SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric ox...
Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).
Read the full Humann Superbeets Heart Chews + Acetaminophen, Codeine, Methocarbamol interactionRed CloverTrifolium Pratense, beebread, clovone, +17 more Unlikely
What it is: Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms...
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover + Acetaminophen, Codeine, Methocarbamol interactionRosemaryRosmarinus Officinalis, alecrim, compass Plant, +14 more Unlikely
What it is: Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts.
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary + Acetaminophen, Codeine, Methocarbamol interactionTheanine Unlikely
What it is: Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without...
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Theanine + Acetaminophen, Codeine, Methocarbamol interactionTurpentine OilPinus Palustris, aceite De Trementina, essence De Térébenthine, +9 more Unlikely
What it is: Turpentine oil is a strong-smelling pine resin product used mostly in tiny amounts in topical rubs for muscle aches and congestion.
There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP activity.
Read the full Turpentine Oil + Acetaminophen, Codeine, Methocarbamol interactionCan You Take It With Acetaminophen, Codeine, Methocarbamol?
One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.
Can you take Magnesium with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect...
Full Magnesium + Acetaminophen, Codeine, Methocarbamol answerCan you take Bitter Orange with Acetaminophen, Codeine, Methocarbamol?
Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
Full Bitter Orange + Acetaminophen, Codeine, Methocarbamol answerCan you take Baikal Skullcap with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Full Baikal Skullcap + Acetaminophen, Codeine, Methocarbamol answerCan you take Gamma-aminobutyric Acid (gaba) with Acetaminophen, Codeine, Methocarbamol?
Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Codeine, Methocarbamol answerCan you take Hesperidin with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Full Hesperidin + Acetaminophen, Codeine, Methocarbamol answerCan you take Pinellia Ternata with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.
Full Pinellia Ternata + Acetaminophen, Codeine, Methocarbamol answerCan you take Pomegranate with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Full Pomegranate + Acetaminophen, Codeine, Methocarbamol answerCan you take Poria Mushroom with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Full Poria Mushroom + Acetaminophen, Codeine, Methocarbamol answerCan you take Propolis with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Full Propolis + Acetaminophen, Codeine, Methocarbamol answerCan you take Quercetin with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.
Full Quercetin + Acetaminophen, Codeine, Methocarbamol answerCan you take Rauvolfia Vomitoria with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.
Full Rauvolfia Vomitoria + Acetaminophen, Codeine, Methocarbamol answerCan you take Rauwolscine with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Full Rauwolscine + Acetaminophen, Codeine, Methocarbamol answerCan you take Red Yeast Rice with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.
Full Red Yeast Rice + Acetaminophen, Codeine, Methocarbamol answerCan you take Rhubarb with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Full Rhubarb + Acetaminophen, Codeine, Methocarbamol answerCan you take Rooibos with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.
Full Rooibos + Acetaminophen, Codeine, Methocarbamol answerCan you take Saffron with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Full Saffron + Acetaminophen, Codeine, Methocarbamol answerCan you take Sage with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Full Sage + Acetaminophen, Codeine, Methocarbamol answerCan you take Saigon Cinnamon with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
Full Saigon Cinnamon + Acetaminophen, Codeine, Methocarbamol answerCan you take Sassafras with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Full Sassafras + Acetaminophen, Codeine, Methocarbamol answerCan you take Sceletium with Acetaminophen, Codeine, Methocarbamol?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Full Sceletium + Acetaminophen, Codeine, Methocarbamol answerWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
How Does Our Interaction Checker Work?
Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).
So the check works in three steps: (1) Acetaminophen, Codeine, Methocarbamol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Codeine, Methocarbamol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.
Acetaminophen, Codeine, Methocarbamol sits in 14 interaction categories. Open any one to see what the group means:
Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
79 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Cns Depressants 78 ingredients
Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.
78 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
60 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Hepatotoxic Drugs 38 ingredients
Medications with known liver considerations. Supplements that can stress the liver add to the load.
38 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
24 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Oral Drugs 17 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
17 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Glucuronidated Drugs 12 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
12 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Acetaminophen (Tylenol, Others) 8 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
8 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Nephrotoxic Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Seizure Threshold Lowering Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Narcotic Drugs 5 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
5 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Skeletal Muscle Relaxants 3 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
3 of the supplement ingredients on this page reach Acetaminophen, Codeine, Methocarbamol through this category.
Codeine 1 ingredient
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
1 of the supplement ingredient on this page reaches Acetaminophen, Codeine, Methocarbamol through this category.
Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
1 of the supplement ingredient on this page reaches Acetaminophen, Codeine, Methocarbamol through this category.
Related: does Acetaminophen, Codeine, Methocarbamol deplete any nutrients?
Acetaminophen, Codeine, Methocarbamol has 2 reported nutrient associations in the research literature — see the Acetaminophen, Codeine, Methocarbamol nutrient depletion report.
Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Codeine, Methocarbamol
Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Codeine, Methocarbamol.
Search a supplement product
Type a product name, brand, or UPC — smart search across our full catalog.
Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI
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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.
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Products that contain Acetaminophen, Codeine, Methocarbamol-interacting ingredients
Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Codeine, Methocarbamol.
Acetaminophen, Codeine, Methocarbamol & Supplements: Common Questions
What supplements interact with Acetaminophen, Codeine, Methocarbamol?
Which Acetaminophen, Codeine, Methocarbamol supplement interactions are the most serious?
Can I take vitamins or supplements while on Acetaminophen, Codeine, Methocarbamol?
Do brands like Acetaminophen, Codeine, Methocarbamol have the same supplement interactions as Acetaminophen, Codeine, Methocarbamol?
Where do these interaction ratings come from?
Does Acetaminophen, Codeine, Methocarbamol deplete any vitamins or nutrients?
What about Acetaminophen, Codeine, Methocarbamol and my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Where This Data Comes From — and Why You Can Trust It
🧪 Licensed clinical database
Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.
🧑⚕️ Pharmacist review
This page is curated and coded by Dr. Brian Staiger, PharmD, BCPS, Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.
🔄 Kept current
Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.
🔍 Full transparency
How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.
Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.