Medication interaction hub

What Supplements Interact with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Amoxicillin, Omeprazole Magnesium, Rifabutin brand name: Talicia. Every interaction below applies to the brands too.

250 Interactions 8 Major 193 Moderate 49 Minor

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Talicia combines amoxicillin, omeprazole, and rifabutin in one capsule to clear H. pylori, and because success depends on all three staying at full strength, the supplements flagged here warrant genuine care rather than a quick skim. Grapefruit can raise rifabutin levels, St. John's wort speeds omeprazole out of the body enough to undercut the treatment, and heavy alcohol adds strain to a liver already handling three drugs at once.

Most of this long list works through the liver enzymes that process rifabutin and omeprazole, nudging their levels up or down, while probiotics simply get killed by the amoxicillin unless doses are spaced well apart, and activated charcoal or bulky fibers can block absorption outright. A few, like Siberian cocklebur, raise kidney concerns. Of the 250 ingredients on file, only eight rate major, against 193 moderate and 49 minor, but those eight are where I would start reading.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amoxicillin, Omeprazole Magnesium, Rifabutin: Top Interactions at a Glance

The Amoxicillin, Omeprazole Magnesium, Rifabutin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

The complete list

Every Supplement Checked Against Amoxicillin, Omeprazole Magnesium, Rifabutin

All 1,452 ingredients in our database, ranked by severity — 250 with a Amoxicillin, Omeprazole Magnesium, Rifabutin interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Straight answers

Can You Take It With Amoxicillin, Omeprazole Magnesium, Rifabutin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bifidobacterium Bifidum with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Caffeine with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Grape with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Betaine Hydrochloride with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Full Betaine Hydrochloride + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Bifidobacterium Breve with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Bifidobacterium Longum with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Cannabidiol (cbd) with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP2C19.

Full Cannabidiol (cbd) + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Coffee Charcoal with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take European Mandrake with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Fermented Milk with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Ginkgo with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.

Full Ginkgo + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Glucomannan with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Guar Gum with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of penicillin, potentially decreasing its effectiveness.

Full Guar Gum + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Guggul with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Gum Arabic with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Gum arabic can reduce the absorption of amoxicillin.

Full Gum Arabic + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Lacticaseibacillus Casei with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Lacticaseibacillus Paracasei with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Lacticaseibacillus Rhamnosus with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Amoxicillin, Omeprazole Magnesium, Rifabutin answer

Can you take Lactiplantibacillus Pentosus with Amoxicillin, Omeprazole Magnesium, Rifabutin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Amoxicillin, Omeprazole Magnesium, Rifabutin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amoxicillin, Omeprazole Magnesium, Rifabutin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amoxicillin, Omeprazole Magnesium, Rifabutin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amoxicillin, Omeprazole Magnesium, Rifabutin sits in 17 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Proton Pump Inhibitors (Ppis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Omeprazole (Prilosec) 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Amoxicillin (Amoxil, Trimox) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Penicillin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amoxicillin, Omeprazole Magnesium, Rifabutin through this category.

Related: does Amoxicillin, Omeprazole Magnesium, Rifabutin deplete any nutrients?

Amoxicillin, Omeprazole Magnesium, Rifabutin has 17 reported nutrient associations in the research literature — see the Amoxicillin, Omeprazole Magnesium, Rifabutin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amoxicillin, Omeprazole Magnesium, Rifabutin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amoxicillin, Omeprazole Magnesium, Rifabutin.

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Pharmacist Counseling Corner

Amoxicillin, Omeprazole Magnesium, Rifabutin & Supplements: Common Questions

What supplements interact with Amoxicillin, Omeprazole Magnesium, Rifabutin?
More than you might expect — 250 in total, though they are far from equal: 8 are rated major, 193 moderate, and 49 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Khat, Siberian Cocklebur.
Which Amoxicillin, Omeprazole Magnesium, Rifabutin supplement interactions are the most serious?
The 8 major-rated combinations — led by Grapefruit, Khat, Siberian Cocklebur, St. John's Wort and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amoxicillin, Omeprazole Magnesium, Rifabutin?
Usually yes — most people on Amoxicillin, Omeprazole Magnesium, Rifabutin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Talicia have the same supplement interactions as Amoxicillin, Omeprazole Magnesium, Rifabutin?
Yes — Talicia all contain Amoxicillin, Omeprazole Magnesium, Rifabutin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amoxicillin, Omeprazole Magnesium, Rifabutin deplete any vitamins or nutrients?
It might — Amoxicillin, Omeprazole Magnesium, Rifabutin has 17 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amoxicillin, Omeprazole Magnesium, Rifabutin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amoxicillin, Omeprazole Magnesium, Rifabutin and my other medications?
This page covers Amoxicillin, Omeprazole Magnesium, Rifabutin against supplements and herbal ingredients. Checking Amoxicillin, Omeprazole Magnesium, Rifabutin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.