Drug & supplement interaction

Propolis + Amoxicillin, Omeprazole Magnesium, Rifabutin

Amoxicillin, Omeprazole Magnesium, Rifabutin brand name: Talicia.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Amoxicillin, Omeprazole Magnesium, Rifabutin falls into 3 drug categories that Propolis can interact with; the most serious is rated moderate. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Propolis and Amoxicillin, Omeprazole Magnesium, Rifabutin

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Propolis interacts with whole categories of medication. Amoxicillin, Omeprazole Magnesium, Rifabutin falls into 3 of those categories, so it can interact with Propolis in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES

1 of 3

Why this applies to Amoxicillin, Omeprazole Magnesium, Rifabutin

Amoxicillin, Omeprazole Magnesium, Rifabutin falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group Propolis interacts with.

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Talicia is a three-in-one combo used to knock out H. pylori, and the part that matters here is the omeprazole. Omeprazole is handled by a liver enzyme called CYP2C19. In a test tube, propolis can slow that same enzyme down, which in theory could let omeprazole build up a bit. Higher omeprazole levels usually just mean more of its normal effects, things like headache, stomach upset, or loose stools.

Here's the reassuring part: this is only lab-dish data. In animal studies propolis didn't really change CYP2C19 in the body, likely because not much of it gets absorbed, and it has never been reported as a problem in people. For most folks, normal propolis use is unlikely to cause trouble. Still, it's worth a quick mention to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  2. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

2 of 3

Amoxicillin, Omeprazole Magnesium, Rifabutin also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Talicia is a three-in-one combo (amoxicillin, omeprazole, and rifabutin) used to knock out H. pylori stomach infections. The concern on file is that, in a test tube, propolis can block the liver enzyme CYP2C9, which could theoretically let certain medicines build up a bit. The good news here is that none of the three drugs in Talicia really lean on CYP2C9 to be cleared, so this particular pathway isn't a major route for them.

On top of that, the evidence is weak. Lab dishes showed some enzyme blocking, but animal studies didn't, and nothing has been seen in people. Everyday or food-level amounts of propolis are very unlikely to cause trouble. Still, if you take concentrated propolis supplements, it never hurts to mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  2. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

3 of 3

Amoxicillin, Omeprazole Magnesium, Rifabutin also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Talicia is a combo of three medicines used to treat H. pylori stomach infections. The one that matters here is rifabutin, which your liver clears using an enzyme called CYP3A4. In a test tube, some propolis compounds can block that enzyme, and in theory that could let rifabutin build up a bit, raising the chance of side effects like nausea, an upset stomach, or harmless orange-colored urine and tears.

Here's the honest part: this concern only comes from lab and animal studies, and it has never actually been seen in people. Real-world propolis doses likely don't reach the levels needed to matter. Still, if you take concentrated propolis supplements, mention it to your pharmacist or doctor so they can keep an eye on things.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  2. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Propolis Also Interacts With Other Medications

Propolis has 922 moderate known drug interactions in our database — the Amoxicillin, Omeprazole Magnesium, Rifabutin one above is among them. If you take anything else, check it against the full list below.

Moderate 922 No known interaction 1,908 (incl. Amoxicillin, Omeprazole Magnesium, Rifabutin)
Taking anything else?

Check Another of Your Medications Against Propolis

Covers the 2,830 medications we’ve checked against Propolis. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Amoxicillin, Omeprazole Magnesium, Rifabutin

This page covers Propolis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amoxicillin, Omeprazole Magnesium, Rifabutin page lists 250 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Grapefruit (major) and Khat (major).

By severity: 8 major · 193 moderate · 49 minor.

From our pharmacist’s overview on the Amoxicillin, Omeprazole Magnesium, Rifabutin page

“Talicia combines amoxicillin, omeprazole, and rifabutin in one capsule to clear H. pylori, and because success depends on all three staying at full strength, the supplements flagged here warrant genuine care rather than a quick skim.”

Reviewed by 2 · Jul 18, 2026

Open the Amoxicillin, Omeprazole Magnesium, Rifabutin interaction page

One more smart check

Taking Propolis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 723 real supplement products containing Propolis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Propolis. Your product may carry other ingredients that interact with Amoxicillin, Omeprazole Magnesium, Rifabutin too, on top of Propolis — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Propolis and Amoxicillin, Omeprazole Magnesium, Rifabutin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Propolis
Top 25%

#229 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amoxicillin, Omeprazole Magnesium, Rifabutin
Top 25%

#531 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Propolis

What is Propolis?

Propolis
  • Cold sores and herpes lesions (topical)
  • Sore throat and mouth sores
  • Wound and skin healing
  • Immune support
  • Oral and gum health

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth sores, and minor wounds, but high-quality evidence is limited for most uses. It is generally well tolerated, but allergic reactions can occur, especially in people allergic to bee products.

Read the full Propolis monograph & all interactions
Keep checking

Other Drugs & Propolis

Browse every other medication we’ve checked against Propolis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
922Moderate
0Minor
1,907No known interaction
922 Moderate 1,907 No interaction
Moderate

922 interactions

Showing 60 of 922 moderate interactions — see all 922 on the Propolis page.

No interaction 1,907 drugs checked — show the list

We also checked Propolis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,907 medications checked with no known interaction — see the full Propolis list.

See the full Propolis interactions page
See every supplement checked against Amoxicillin, Omeprazole Magnesium, Rifabutin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Propolis monograph › Uses, safety, and every drug interaction in one place Amoxicillin, Omeprazole Magnesium, Rifabutin supplement interactions › Every supplement checked against Amoxicillin, Omeprazole Magnesium, Rifabutin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Propolis and Amoxicillin, Omeprazole Magnesium, Rifabutin Together: Common Questions

Can you take Propolis with Amoxicillin, Omeprazole Magnesium, Rifabutin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Propolis and Amoxicillin, Omeprazole Magnesium, Rifabutin?
Amoxicillin, Omeprazole Magnesium, Rifabutin belongs to more than one drug category, and Propolis interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Propolis and Amoxicillin, Omeprazole Magnesium, Rifabutin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amoxicillin, Omeprazole Magnesium, Rifabutin and Propolis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.