Medication interaction hub

What Supplements Interact with Butabarbital, Phenobarbital, Secobarbital?

Butabarbital, Phenobarbital, Secobarbital brand name: S.B.P.. Every interaction below applies to the brands too.

141 Interactions 8 Major 115 Moderate 18 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Butabarbital, Phenobarbital, Secobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Butabarbital, Phenobarbital, Secobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

141 supplements and herbal ingredients have interactions with Butabarbital, Phenobarbital, Secobarbital on file in the HelloPharmacist interaction database — 8 rated major, 115 moderate, and 18 minor. The most serious involve Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal.

Our assessment: with 8 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Butabarbital, Phenobarbital, Secobarbital.

Major 8 Moderate 115 Minor 18 No known interaction 1,311

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Butabarbital, Phenobarbital, Secobarbital: Top Interactions at a Glance

The most significant Butabarbital, Phenobarbital, Secobarbital supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 141 interacting ingredients — plus 1,311 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Butabarbital, Phenobarbital, Secobarbital + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Butabarbital, Phenobarbital, Secobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely St. John's Wort + Butabarbital, Phenobarbital, Secobarbitali

St.

Read the full interaction Major Likelihood Likely Wine + Butabarbital, Phenobarbital, Secobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Butabarbital, Phenobarbital, Secobarbitali

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Butabarbital, Phenobarbital, Secobarbitali

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Butabarbital, Phenobarbital, Secobarbitali

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction
The complete list

Every Supplement Checked Against Butabarbital, Phenobarbital, Secobarbital

All 1,452 ingredients in our database, ranked by severity — 141 with a Butabarbital, Phenobarbital, Secobarbital interaction on file and 1,311 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Butabarbital, Phenobarbital, Secobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Artichoke with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.

Full Artichoke + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Ashwagandha with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Astaxanthin with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.

Full Astaxanthin + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Bay Leaf with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Berberine with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Bitter Almond with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Black Seed with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Black Tea with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Black Tea + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Boneset with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Borage with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Full Borage + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Butterbur with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Caffeine with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Caffeine + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Calamus with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Butabarbital, Phenobarbital, Secobarbital answer

Can you take California Poppy with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Cannabichromene (cbc) with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Cannabidiol (cbd) with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Cannabinol (cbn) with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabinol might increase the levels and clinical effects of CYP2B6 substrates.

Full Cannabinol (cbn) + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Cannabis with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Caraway with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Butabarbital, Phenobarbital, Secobarbital answer

Can you take Catnip with Butabarbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Butabarbital, Phenobarbital, Secobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Butabarbital, Phenobarbital, Secobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Butabarbital, Phenobarbital, Secobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Butabarbital, Phenobarbital, Secobarbital sits in 9 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Butabarbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Butabarbital, Phenobarbital, Secobarbital through this category.

Related: does Butabarbital, Phenobarbital, Secobarbital deplete any nutrients?

Butabarbital, Phenobarbital, Secobarbital has 7 reported nutrient associations in the research literature — see the Butabarbital, Phenobarbital, Secobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Butabarbital, Phenobarbital, Secobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Butabarbital, Phenobarbital, Secobarbital.

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Products that contain Butabarbital, Phenobarbital, Secobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Butabarbital, Phenobarbital, Secobarbital.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Butabarbital, Phenobarbital, Secobarbital & Supplements: Common Questions

What supplements interact with Butabarbital, Phenobarbital, Secobarbital?
More than you might expect — 141 in total, though they are far from equal: 8 are rated major, 115 moderate, and 18 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Butabarbital, Phenobarbital, Secobarbital supplement interactions are the most serious?
The 8 major-rated combinations — led by Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Butabarbital, Phenobarbital, Secobarbital?
Usually yes — most people on Butabarbital, Phenobarbital, Secobarbital can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like S.B.P. have the same supplement interactions as Butabarbital, Phenobarbital, Secobarbital?
Yes — S.B.P. all contain Butabarbital, Phenobarbital, Secobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Butabarbital, Phenobarbital, Secobarbital deplete any vitamins or nutrients?
It might — Butabarbital, Phenobarbital, Secobarbital has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Butabarbital, Phenobarbital, Secobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Butabarbital, Phenobarbital, Secobarbital and my other medications?
This page covers Butabarbital, Phenobarbital, Secobarbital against supplements and herbal ingredients. Checking Butabarbital, Phenobarbital, Secobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.