Medication interaction hub

What Supplements Interact with Chloroquine, Primaquine Phosphate?

Chloroquine, Primaquine Phosphate brand name: Aralen / Primaquine. Every interaction below applies to the brands too.

30 Interactions 2 Major 19 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chloroquine, Primaquine Phosphate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chloroquine, Primaquine Phosphate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

30 supplements and herbal ingredients have interactions with Chloroquine, Primaquine Phosphate on file in the HelloPharmacist interaction database — 2 rated major, 19 moderate, and 9 minor. The most serious involve Activated Charcoal and Hibiscus Sabdariffa.

Our assessment: with 2 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Chloroquine, Primaquine Phosphate.

Major 2 Moderate 19 Minor 9 No known interaction 1,422

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Chloroquine, Primaquine Phosphate: Top Interactions at a Glance

The most significant Chloroquine, Primaquine Phosphate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 30 interacting ingredients — plus 1,422 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Chloroquine, Primaquine Phosphate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Chloroquine, Primaquine Phosphatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Hibiscus Sabdariffa + Chloroquine, Primaquine Phosphatei

Taking Hibiscus sabdariffa tea along with chloroquine seems to reduce levels of chloroquine.

Read the full interaction
The complete list

Every Supplement Checked Against Chloroquine, Primaquine Phosphate

All 1,452 ingredients in our database, ranked by severity — 30 with a Chloroquine, Primaquine Phosphate interaction on file and 1,422 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chloroquine, Primaquine Phosphate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Slippery Elm with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Chloroquine, Primaquine Phosphate answer

Can you take Xanthan Gum with Chloroquine, Primaquine Phosphate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Chloroquine, Primaquine Phosphate answer

Can you take Activated Charcoal with Chloroquine, Primaquine Phosphate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Chloroquine, Primaquine Phosphate answer

Can you take Hibiscus Sabdariffa with Chloroquine, Primaquine Phosphate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Taking Hibiscus sabdariffa tea along with chloroquine seems to reduce levels of chloroquine.

Full Hibiscus Sabdariffa + Chloroquine, Primaquine Phosphate answer

Can you take Coffee Charcoal with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Chloroquine, Primaquine Phosphate answer

Can you take European Mandrake with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Chloroquine, Primaquine Phosphate answer

Can you take Glucomannan with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Chloroquine, Primaquine Phosphate answer

Can you take Khat with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Chewing khat after taking chloroquine appears to decrease the absorption of chloroquine.

Full Khat + Chloroquine, Primaquine Phosphate answer

Can you take Yohimbe with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Full Yohimbe + Chloroquine, Primaquine Phosphate answer

Can you take Biofeedback with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Chloroquine, Primaquine Phosphate answer

Can you take Dendrobium with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Chloroquine, Primaquine Phosphate answer

Can you take Fever Bark with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP2D6 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Full Fever Bark + Chloroquine, Primaquine Phosphate answer

Can you take Ginkgo with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Chloroquine, Primaquine Phosphate answer

Can you take Grapefruit with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Grapefruit juice may increase blood levels of primaquine, potentially increasing the effects and adverse effects of primaquine.

Full Grapefruit + Chloroquine, Primaquine Phosphate answer

Can you take Guar Gum with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Chloroquine, Primaquine Phosphate answer

Can you take Gum Arabic with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Chloroquine, Primaquine Phosphate answer

Can you take Iboga with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with CYP2D6 inhibitors might increase the levels and clinical effects of ibogaine.

Full Iboga + Chloroquine, Primaquine Phosphate answer

Can you take Melatonin with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Chloroquine, Primaquine Phosphate answer

Can you take N-acetyl Cysteine (nac) with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.

Full N-acetyl Cysteine (nac) + Chloroquine, Primaquine Phosphate answer

Can you take Rauwolscine with Chloroquine, Primaquine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Chloroquine, Primaquine Phosphate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chloroquine, Primaquine Phosphate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chloroquine, Primaquine Phosphate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chloroquine, Primaquine Phosphate sits in 5 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chloroquine, Primaquine Phosphate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chloroquine, Primaquine Phosphate through this category.

Chloroquine (Aralen) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Chloroquine, Primaquine Phosphate through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chloroquine, Primaquine Phosphate through this category.

Primaquine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chloroquine, Primaquine Phosphate through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chloroquine, Primaquine Phosphate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chloroquine, Primaquine Phosphate.

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Pharmacist Counseling Corner

Chloroquine, Primaquine Phosphate & Supplements: Common Questions

What supplements interact with Chloroquine, Primaquine Phosphate?
Our database currently documents 30 ingredients with a known Chloroquine, Primaquine Phosphate interaction (2 major, 19 moderate, 9 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 30. The highest-ranked right now: Activated Charcoal, Hibiscus Sabdariffa, Coffee Charcoal.
Which Chloroquine, Primaquine Phosphate supplement interactions are the most serious?
The 2 major-rated combinations — led by Activated Charcoal and Hibiscus Sabdariffa — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Chloroquine, Primaquine Phosphate?
Plenty of supplements coexist fine with Chloroquine, Primaquine Phosphate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Aralen / Primaquine have the same supplement interactions as Chloroquine, Primaquine Phosphate?
Yes — Aralen / Primaquine all contain Chloroquine, Primaquine Phosphate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chloroquine, Primaquine Phosphate and my other medications?
This page covers Chloroquine, Primaquine Phosphate against supplements and herbal ingredients. Checking Chloroquine, Primaquine Phosphate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.