Medication interaction hub

What Supplements Interact with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium brand name: Pylera. Every interaction below applies to the brands too.

148 Interactions 6 Major 128 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Metronidazole, Tetracyline, Bismuth Subcitrate Potassium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol is the risk to handle first with Pylera (metronidazole, tetracycline, and bismuth subcitrate potassium, usually prescribed for H. pylori stomach infections). Beer and wine both carry major ratings, since alcohol adds to the liver strain this combination already causes, and metronidazole mixed with alcohol can trigger flushing, nausea, and a pounding heart. Even remedies preserved in alcohol qualify. Six of the 148 ingredients on file rate major, so I would treat this list with real caution rather than a quick skim.

Beyond alcohol, calcium and similar minerals bind tetracycline in the gut and blunt its absorption, so space them well apart from each dose. Activated charcoal, another major entry, can soak up the medications themselves. Twenty ingredients add sun sensitivity, probiotics tend to be killed off by the antibiotics, and two kidney-stressing plants also sit at the major level. The 128 moderate and 14 minor entries largely echo these same themes at a milder pitch.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 128 Minor 14 No known interaction 1,304

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium: Top Interactions at a Glance

The most significant Metronidazole, Tetracyline, Bismuth Subcitrate Potassium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Metronidazole, Tetracyline, Bismuth Subcitrate Potassium + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Oleander + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.

Read the full interaction Major Likelihood Probable Wine + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Possible Asarabacca + Metronidazole, Tetracyline, Bismuth Subcitrate Potassiumi

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Metronidazole, Tetracyline, Bismuth Subcitrate Potassium

All 1,452 ingredients in our database, ranked by severity — 148 with a Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Riboflavin with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.

Full Riboflavin + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Red Yeast Rice with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Bromelain with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bromelain might increase levels of tetracycline antibiotics.

Full Bromelain + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactiplantibacillus Pentosus with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactiplantibacillus Plantarum with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Plantarum + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Acidophilus with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Crispatus with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Crispatus + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Delbrueckii with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Delbrueckii + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Gasseri with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Gasseri + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Helveticus with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Helveticus + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Jensenii with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Lactobacillus Johnsonii with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Latilactobacillus Sakei with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Levilactobacillus Brevis with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Ligilactobacillus Salivarius with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Limosilactobacillus Fermentum with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Limosilactobacillus Reuteri with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Reuteri + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Magnesium with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium decreases absorption of tetracyclines.

Full Magnesium + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Manganese with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, manganese might reduce the absorption of tetracycline antibiotics.

Full Manganese + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer

Can you take Masterwort with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effec...

Full Masterwort + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium answer
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What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Metronidazole, Tetracyline, Bismuth Subcitrate Potassium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Metronidazole, Tetracyline, Bismuth Subcitrate Potassium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium sits in 10 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Tetracycline Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

Metronidazole (Flagyl) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Metronidazole, Tetracyline, Bismuth Subcitrate Potassium through this category.

About Metronidazole, Tetracyline, Bismuth Subcitrate Potassium

Bismuth, metronidazole, and tetracycline is a three-ingredient antibiotic combination used to eliminate Helicobacter pylori infection in people with active duodenal ulcers or a history of duodenal ulcer disease.

Generic name: Metronidazole, Tetracyline, Bismuth Subcitrate Potassium  ·  Brand name: Pylera.

See the full Bismuth, Metronidazole, and Tetracycline drug information

Related: does Metronidazole, Tetracyline, Bismuth Subcitrate Potassium deplete any nutrients?

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium has 11 reported nutrient associations in the research literature — see the Metronidazole, Tetracyline, Bismuth Subcitrate Potassium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Metronidazole, Tetracyline, Bismuth Subcitrate Potassium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Metronidazole, Tetracyline, Bismuth Subcitrate Potassium.

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Products that contain Metronidazole, Tetracyline, Bismuth Subcitrate Potassium-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Metronidazole, Tetracyline, Bismuth Subcitrate Potassium & Supplements: Common Questions

What supplements interact with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?
Our database currently documents 148 ingredients with a known Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interaction (6 major, 128 moderate, 14 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 148. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Metronidazole, Tetracyline, Bismuth Subcitrate Potassium supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Oleander and Wine, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?
Plenty of supplements coexist fine with Metronidazole, Tetracyline, Bismuth Subcitrate Potassium; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Pylera have the same supplement interactions as Metronidazole, Tetracyline, Bismuth Subcitrate Potassium?
Yes — Pylera all contain Metronidazole, Tetracyline, Bismuth Subcitrate Potassium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Metronidazole, Tetracyline, Bismuth Subcitrate Potassium deplete any vitamins or nutrients?
It might — Metronidazole, Tetracyline, Bismuth Subcitrate Potassium has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Metronidazole, Tetracyline, Bismuth Subcitrate Potassium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Metronidazole, Tetracyline, Bismuth Subcitrate Potassium and my other medications?
This page covers Metronidazole, Tetracyline, Bismuth Subcitrate Potassium against supplements and herbal ingredients. Checking Metronidazole, Tetracyline, Bismuth Subcitrate Potassium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bismuth, Metronidazole, and Tetracycline drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.