Medication interaction hub

What Supplements Interact with Pargyline?

Pargyline brand name: Eutonyl. Every interaction below applies to the brands too.

136 Interactions 4 Major 111 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pargyline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pargyline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Pargyline (Eutonyl) is an older blood pressure medicine that works as an MAO inhibitor, and that mechanism makes this a list to read carefully rather than skim. Of the 136 supplements and herbs on file, four carry a major rating, and tyramine, found in aged cheeses, cured meats, and some fermented products, is the one to understand first, since it can push blood pressure upward and undercut the drug's control. Most of the 111 moderate entries pull the opposite direction, adding to the pressure-lowering effect, and everyday items like fish oil sit in that group.

A smaller cluster of 17 ingredients, activated charcoal among them, can blunt the absorption of medicines taken by mouth, Pargyline included, so those belong well apart from your dose. The 21 minor entries carry less weight, but with four major flags attached to one medication, this page deserves genuine attention, beginning with those four.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 111 Minor 21 No known interaction 1,316

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Pargyline: Top Interactions at a Glance

The most significant Pargyline supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 136 interacting ingredients — plus 1,316 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Pargyline + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Pargylinei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Pargylinei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Pargylinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Pargylinei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction
The complete list

Every Supplement Checked Against Pargyline

All 1,452 ingredients in our database, ranked by severity — 136 with a Pargyline interaction on file and 1,316 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pargyline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Docosahexaenoic Acid (dha) with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Pargyline answer

Can you take Tribulus with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Pargyline answer

Can you take Sodium with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Pargyline answer

Can you take American Hellebore with Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Full American Hellebore + Pargyline answer

Can you take Tyramine with Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Full Tyramine + Pargyline answer

Can you take Activated Charcoal with Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Pargyline answer

Can you take American Mistletoe with Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially...

Full American Mistletoe + Pargyline answer

Can you take Apple with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Full Apple + Pargyline answer

Can you take Banaba with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.

Full Banaba + Pargyline answer

Can you take Beer with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Beer + Pargyline answer

Can you take Casein Peptides with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.

Full Casein Peptides + Pargyline answer

Can you take Cat's Claw with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.

Full Cat's Claw + Pargyline answer

Can you take Celery with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Pargyline answer

Can you take Coca with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antihypertensive drugs.

Full Coca + Pargyline answer

Can you take Cod Liver Oil with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.

Full Cod Liver Oil + Pargyline answer

Can you take Coffee Charcoal with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Pargyline answer

Can you take Eicosapentaenoic Acid (epa) with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Pargyline answer

Can you take European Mandrake with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Pargyline answer

Can you take Fever Bark with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might alter the effects of antihypertensive drugs.

Full Fever Bark + Pargyline answer

Can you take Fish Oil with Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Pargyline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pargyline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pargyline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pargyline sits in 2 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Pargyline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pargyline through this category.

Related: does Pargyline deplete any nutrients?

Pargyline has 1 reported nutrient association in the research literature — see the Pargyline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Pargyline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pargyline.

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Products that contain Pargyline-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Pargyline.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Pargyline & Supplements: Common Questions

What supplements interact with Pargyline?
Our database currently documents 136 ingredients with a known Pargyline interaction (4 major, 111 moderate, 21 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 136. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Pargyline supplement interactions are the most serious?
The 4 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Pargyline?
Plenty of supplements coexist fine with Pargyline; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Eutonyl have the same supplement interactions as Pargyline?
Yes — Eutonyl all contain Pargyline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Pargyline deplete any vitamins or nutrients?
It might — Pargyline has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Pargyline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Pargyline and my other medications?
This page covers Pargyline against supplements and herbal ingredients. Checking Pargyline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.