No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

100% Pure L-Methionine Ingredients & Drug Interactions

by NutraBio

100% Pure L-Methionine label
See full label image
Powder Category: Amino Acid/protein
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure L-Methionine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

100% Pure L-Methionine is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of 100% Pure L-Methionine by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Methionine, an amino acid your body uses to build proteins and produce other important compounds like glutathione and carnitine. It's found naturally in protein-containing foods like meat, eggs, and dairy.

There are no inactive ingredients listed — it's just the L-Methionine in powder form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Methionine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Methionine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Neural tube birth defects — rated "Possibly Effective" (Natural Medicines).

L-Methionine is possibly effective for reducing the risk of neural tube birth defects (birth defects of the brain and spine that develop very early in pregnancy). For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence we hold is insufficient to say whether it works.

If you're considering it for a specific reason, your doctor or pharmacist can help you weigh what's known.

The evidence, ingredient by ingredient Methionine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Methionine from food sources is well tolerated. High-dose supplements, though, may cause dizziness, drowsiness, low blood pressure (hypotension), irritability, vomiting, headache, or changes in blood calcium and white blood cell levels.

In rare cases, serious effects like brain swelling (cerebral edema) have occurred. High doses can also raise homocysteine levels, which is a risk factor for vascular disease — though one study in people with type 2 diabetes and a history of heart disease found no increase.

In pregnancy, normal dietary amounts are fine, but the safety of supplement doses has not been proven. Supplement safety while breastfeeding is not well studied.

Talk with your doctor or pharmacist before using this if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Methionine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-Methionine. Still, check your exact medications with the search tool on this page before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

If you're looking for an L-Methionine supplement and have no documented interactions with your medications, this is a straightforward option. It's particularly relevant if you're pregnant or planning to become pregnant and want to support neural tube development — but check with your OB/GYN first.

Because high doses can raise homocysteine and cause side effects, use it under medical guidance rather than on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure L-Methionine, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908235147
Net contents 8.8 Oz(s); 250 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50959
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure L-Methionine by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Gram(s)
Maximum serving Sizes:
1.5 Gram(s)
Servings per container
166
UPC/BARCODE
649908235147
IngredientAmount% DV
L-Methionine1500 mg--

Other ingredients: Absolutely None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pharmaceutical Grade HPLC Lab tested for potency

Manufactured in a GMP & FDA inspected facility

Quality & purity since 1996. NutraBio manufactures in our own FDA registered & inspected GMP facility complying with FDA 21 CFR Part 111 regulations.

Pharmaceutical Free Form Amino Acid

Powder 166 servings

Made in a GMP & FDA inspected facility

Serving scoop included (may settle to the bottom during shipping.)

Suggested/Recommended/Usage/Directions

1 Serving~ Mixed with 8-16 oz. Favorite Beverage~ 1-2x daily~ with food Suggested Use: As a dietary supplement, mix 1 level scoop into your favorite beverage 1 to 2 times daily preferably with meals, or as directed by your physician. May be hygroscopic and may clump during storage which will not affect the quality of the product.

Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of the reach of children.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Allergen Free

Formulation

Vegetarian

Non-GMO Gluten Free BSE/TSE Free

No FIllers No Excipients No Additives

Free of Harmful Impurities

Brand IP Statement(s)

Amino Therapy

Seals/Symbols

TRUE LABEL FULL LABEL DISCLOSURE

OU

NUTRABIO Since 1996

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

23514-000 B20262-002

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure L-Methionine by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure L-Methionine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure L-Methionine by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 Gram(s) Dosage formPowder Servings per container166 Amounts shown are per serving.

L-Methionine

No known
interactions
1500 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

L-Methionine monograph & interactions

Other (inactive) ingredients: Absolutely None. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure L-Methionine by NutraBio Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in 100% Pure L-Methionine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for 100% Pure L-Methionine, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Pure L-Methionine by NutraBio: Common Questions

Does 100% Pure L-Methionine by NutraBio interact with any medications?
We do not currently list a known interaction for the mapped ingredients in 100% Pure L-Methionine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
100% Pure L-Methionine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-Methionine used for?
L-Methionine is an amino acid your body uses to build proteins and produce compounds like glutathione (an antioxidant) and carnitine. It's possibly effective for reducing neural tube birth defects. For other uses like hay fever or asthma, the evidence we hold isn't strong enough to say whether it works.
Are there side effects?
At food amounts, L-Methionine is well tolerated. High-dose supplements can cause dizziness, drowsiness, low blood pressure, irritability, vomiting, or headache. Very high doses may raise homocysteine levels, which is a risk factor for heart disease. Serious effects like brain swelling are rare but possible.
Is it safe during pregnancy?
Normal dietary amounts are fine. The safety of supplement doses in pregnancy hasn't been proven, so talk with your OB/GYN before starting a supplement, especially if you're interested in it for neural tube defect prevention.
What about breastfeeding?
Food amounts are expected to be safe, but the safety of supplement doses while breastfeeding is not well studied. Check with your doctor before taking this supplement if you're breastfeeding.
Does it interact with medications?
No interactions are documented in our data for L-Methionine. Still, run your exact medications through the checker on this page to be sure, and ask your pharmacist if you have questions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure L-Methionine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure L-Methionine label
Go deeper

The Full Monographs Behind 100% Pure L-Methionine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Sources

Sources & How We Checked

100% Pure L-Methionine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team