Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

5-HTP Plus 200 mg Ingredients & Drug Interactions

by Dr. Emil Nutrition

5-HTP Plus 200 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 5-HTP Plus 200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

5-HTP Plus 200 mg is a dietary supplement by Dr. Emil Nutrition with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 572 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are 5-Hydroxytryptophan, L-Tryptophan, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 5-HTP Plus 200 mg by Dr. Emil Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP Plus 200 mg by Dr. Emil Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of 5-HTP Plus 200 mg by Dr. Emil Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 4 active ingredients. Vitamin B6 supports nervous system and red blood cell health.

5-Hydroxytryptophan (5-HTP) is a compound your body makes from tryptophan and uses to produce serotonin, a neurotransmitter involved in mood and sleep. L-tryptophan is an amino acid your body converts into 5-HTP and serotonin.

SAMe is a compound involved in methylation reactions — chemical processes that support joint health, mood, and liver function. The capsule also contains inactive ingredients: microcrystalline cellulose, magnesium stearate, silicon dioxide, and hypromellose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Mood, sleep, and anxiety support.
  • We looked for evidence on: Anxiety, Depression, Insomnia, Fibromyalgia, Migraine headache, Stress — and 2 related terms.
  • The strongest evidence on file: Same is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: 5-htp is rated "Possibly Effective" for Depression.
  • Also on file: L-tryptophan is rated "Possibly Ineffective" for Depression.

Vitamin B6 is Effective for sideroblastic anemia and B6 deficiency, and Likely Effective for lowering homocysteine levels (a heart-health marker). It's Possibly Effective for pregnancy-related nausea and vomiting.

5-HTP is Possibly Effective for depression, but evidence for other uses — Alzheimer's disease, panic disorder, and cerebellar ataxia — is insufficient to rate. L-tryptophan is rated Possibly Ineffective for depression, and evidence for anxiety, athletic performance, teeth-grinding, and PMS is insufficient.

SAMe is Likely Effective for osteoarthritis and Possibly Effective for depression and cholestasis (liver bile-flow problems), but evidence for Alzheimer's disease and ADHD is insufficient.

The evidence, ingredient by ingredient Vitamin B6 5-htp L-tryptophan Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated in doses under 100 mg daily. At higher doses over time, it can damage nerves (sensory neuropathy), though this is rare at lower intakes.

Common side effects include headache, nausea, and loss of appetite. 5-HTP is generally well tolerated short-term but commonly causes nausea, diarrhea, headache, and drowsiness — effects that may improve with continued use.

Serious but rare side effects include hallucinations and mania. L-tryptophan is generally well tolerated, though it can cause drowsiness, nausea, and headache.

It has a historical association with a contamination-related illness (eosinophilia-myalgia syndrome) from a 1989 outbreak, but current products are considered safe. SAMe is generally well tolerated at standard doses; common effects are nausea, diarrhea, and constipation.

It may trigger mania in people with bipolar disorder. Regarding pregnancy: Vitamin B6 is Likely Safe but also rated Possibly Unsafe — use only under doctor guidance.

5-HTP and L-tryptophan safety data in pregnancy are insufficient; the facts advise against use. SAMe is Possibly Safe in pregnancy.

For breastfeeding, Vitamin B6 and L-tryptophan are Likely Safe; 5-HTP and SAMe lack sufficient data — talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Vitamin B6 5-htp L-tryptophan Same

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — L-tryptophan, Same, 5-htp, Vitamin B6.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 572 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check the following medication types before taking this product, worst severity first: CNS depressants (sedating medications, sleep aids, alcohol) — L-tryptophan carries a Major risk of additive drowsiness; serotonergic drugs (antidepressants, some migraine and pain medications) — Moderate risk of serotonin syndrome from 5-HTP, L-tryptophan, and SAMe combined; blood pressure medications (antihypertensives) — Moderate risk from Vitamin B6; seizure medications (phenobarbital, phenytoin) — Moderate risk from high-dose B6; amiodarone (heart rhythm medication) — Moderate risk from B6; carbidopa and levodopa (Parkinson's medications) — Moderate risk from 5-HTP and SAMe. No interactions are documented for the inactive ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient serotonin-support supplement best suited for people exploring mood or sleep support under professional guidance. If you take any antidepressant, seizure medication, heart rhythm drug, blood pressure medication, or Parkinson's medication, check your exact drugs with the tool below before starting.

Anyone on sedating medications or with a history of bipolar disorder should talk with their pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 5-HTP Plus 200 mg, straight from the product label.

Brand Dr. Emil Nutrition
Barcode (UPC) 850002956207
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272247
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 5-HTP Plus 200 mg by Dr. Emil Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
850002956207
IngredientAmount% DV
Total Carbohydrates1 Gram(s)--
Vitamin B610 mg588%
5-Hydroxytryptophan200 mg--
L-Tryptophan20 mg--
SAMe20 mg--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two (2) capsules once daily, with at least 8 oz. of water or as directed by a healthcare professional. Do not exceed recommended dosage in 24 hour period.

Precautions

Keep out of reach of children.

Caution: Do not use if pregnant or nursing.

Do not exceed recommended dosage in 24 hour period. Do not exceed recommended dose.

If you are taking any medication or are under the care of a physician for depression or related disorder, contact your physician before using this product.

May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Product has been manufactured at a cGMP facility.

Supports brain function, mood & sleep

Vegan friendly

Gluten free

Formula

5-HTP Plus With co-factor B6

Plus serotonin synthesizers

FDA Statement of Identity

Dietary Supplement

General Statements

30-day supply

Seals/Symbols

Manufactured in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

5-HTP Plus 200 mg by Dr. Emil Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

5-HTP Plus 200 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 5-HTP Plus 200 mg by Dr. Emil Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

5-Hydroxytryptophan

Interacts with
398 drugs
200 mg per serving

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-Hydroxytryptophan monograph & interactions

L-Tryptophan

Interacts with
394 drugs
20 mg per serving

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for...

L-Tryptophan monograph & interactions

SAMe

Interacts with
189 drugs
20 mg per serving

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

SAMe monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

5-HTP Plus 200 mg by Dr. Emil Nutrition Drug Interactions

Want to check YOUR meds against 5-HTP Plus 200 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
572Drugs
248 Major 324 Moderate

Ingredients driving the most interactions

5-Hydroxytryptophan 398
L-Tryptophan 394
Vitamin B6 210
SAMe 189

Individual Drug Interactions

The ingredients in 5-HTP Plus 200 mg interact with 572 drugs. Click any drug to see the details.

4 of the 4 ingredients in 5-HTP Plus 200 mg interact with drugs. Each result below shows which ingredient is responsible. 5-Hydroxytryptophan L-Tryptophan Vitamin B6 SAMe

Each ingredient & the kinds of drugs it affects

For each ingredient in 5-HTP Plus 200 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

5-Hydroxytryptophan3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-Hydroxytryptophan full monograph & interactions

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

SAMe2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
SAMe full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 5-HTP Plus 200 mg, from the product label.

Dr. Emil Nutrition

See all Dr. Emil Nutrition products
Name
Dr. Emil Nutrition
Street Address
3706 Butler Street
City
Pittsburgh
State
PA
ZipCode
15201
Phone Number
884-437-3645
Web Address
dremilnutrition.com
Pharmacist Counseling Corner

5-HTP Plus 200 mg by Dr. Emil Nutrition: Common Questions

Does 5-HTP Plus 200 mg by Dr. Emil Nutrition interact with any medications?
Yes. Based on its ingredients, 5-HTP Plus 200 mg has a known interaction with 572 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
5-HTP Plus 200 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Vitamin B6 is Likely Safe in pregnancy but also rated Possibly Unsafe — use only under doctor guidance. 5-HTP and L-tryptophan should be avoided in pregnancy due to insufficient safety data. SAMe is Possibly Safe. For breastfeeding, Vitamin B6 and L-tryptophan are Likely Safe, but 5-HTP and SAMe lack enough data — talk with your doctor or pharmacist for personalized advice.
What side effects might I notice?
The most common are nausea, diarrhea, headache, and drowsiness — these tend to be dose-dependent and may improve with continued use. Less common are loss of appetite, vomiting, and insomnia. High doses of Vitamin B6 over time can harm nerves. Serious side effects are rare but can include hallucinations or mania.
Does this actually help with depression?
5-HTP is Possibly Effective for depression, meaning some evidence supports it but results vary. Vitamin B6 and SAMe are also Possibly Effective for depression. L-tryptophan is rated Possibly Ineffective. Talk with your doctor about whether this is right for you alongside any other treatments.
Why does this product have both 5-HTP and L-tryptophan?
L-tryptophan is an amino acid your body converts into 5-HTP, which then becomes serotonin. Both ingredients work in the same pathway, so combining them provides complementary approaches to supporting serotonin production.
Is L-tryptophan safe after the 1989 contamination scare?
Yes. In 1989, a single Japanese manufacturer produced contaminated L-tryptophan that caused illness in over 1,500 people. Since then, imports have been regulated and products are considered safe. Today's L-tryptophan supplements are held to safety standards.
Can this cause serotonin syndrome?
Theoretically, yes, especially if you combine this product with antidepressants or other serotonin-boosting medications. The risk is Moderate with 5-HTP, L-tryptophan, and SAMe together. This is why checking your medications with our tool before starting is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 5-HTP Plus 200 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

5-HTP Plus 200 mg label
Go deeper

The Full Monographs Behind 5-HTP Plus 200 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph → Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Same

Interacts with 189 drugs

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the qu...

Read the full Same monograph →
Sources

Sources & How We Checked

5-HTP Plus 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 113 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
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