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Dietary supplement

Acetyl L-Carnitine 500 mg Ingredients & Drug Interactions

by SimplySupplements

Acetyl L-Carnitine 500 mg label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acetyl L-Carnitine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acetyl L-Carnitine 500 mg is a dietary supplement by SimplySupplements with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve pain (neuropathy), energy and fatigue.Based on those ingredients, 203 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acetyl L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acetyl L-Carnitine 500 mg by SimplySupplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Acetyl L-Carnitine 500 mg by SimplySupplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acetyl L-Carnitine 500 mg by SimplySupplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Acetyl L-Carnitine, 500 mg per capsule. Acetyl L-Carnitine is a form of carnitine, a compound involved in energy production in your cells.

It's also found in small amounts in red meat and dairy. The capsule also contains inactive ingredients: magnesium stearate (a flow agent), gelatin (the capsule shell), and titanium dioxide (a whitening agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: antioxidant for normal mental function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Depression, Schizophrenia, cognitive impairment — and 2 related terms.
  • The strongest evidence on file: Acetyl-l-carnitine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Acetyl-l-carnitine is rated "Possibly Effective" for Alzheimer disease, Depression.
  • Also on file: Acetyl-l-carnitine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Schizophrenia.

Acetyl L-Carnitine is rated possibly effective for several conditions based on available evidence. These include age-related cognitive decline, Alzheimer disease, alcohol use disorder, diabetic neuropathy (nerve damage from diabetes), and depression.

That means the science suggests it may help, but the evidence isn't yet conclusive — more or stronger studies are needed to be sure.

The evidence, ingredient by ingredient Acetyl-l-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, Acetyl L-Carnitine is generally well tolerated over the short term, though long-term safety data are limited. The most common side effects are agitation, dry mouth, headache, insomnia, and reduced appetite.

Some people report a fishy odor in urine, breath, or sweat. Gastrointestinal upset — nausea, diarrhea, constipation, or abdominal pain — can occur, though it's not more common than with placebo in most studies.

For pregnancy, there isn't enough reliable safety information, so you'd need to talk with your doctor or midwife first. The same goes for breastfeeding — safety data are unknown, and avoiding it is the safer choice unless your doctor advises otherwise.

Side effects, ingredient by ingredient Acetyl-l-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Acetyl-l-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 203 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on any serotonergic antidepressants or mood medications (SSRIs, SNRIs, or others that raise serotonin), blood thinners like warfarin or acenocoumarol, or thyroid hormone replacement. These are Moderate-severity interactions documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Acetyl L-Carnitine may be worth considering if you're interested in cognitive or mood support and your doctor thinks it fits your situation. If you take any antidepressant, blood thinner, or thyroid medication, check with your pharmacist first — interactions are possible.

Pregnant or breastfeeding? Talk to your doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acetyl L-Carnitine 500 mg, straight from the product label.

Brand SimplySupplements
Barcode (UPC) 5060208416398
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22417
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acetyl L-Carnitine 500 mg by SimplySupplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
5060208416398
IngredientAmount% DV
Acetyl L-Carnitine500 mg--

Other ingredients: Magnesium Stearate, Gelatin, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Food supplement: This product should not be used as a substitute for a varied diet.

Important Information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or Pharmacist prior to taking supplements.

Do not exceed the stated dose.

Keep away from children at all times.

Do not use if the seal is broken.

Pregnant or lactating women should consult a doctor befoere using this product.

Allergy Advice: Contains an ingredient derived from Beef.

Seals/Symbols

EasyGest CAPSULES

SimplySupplements(TM)

QUALITY ASSURED

General Statements

- Easy to Swallow - Easy to Absorb - Easy to Digest - No Product Odour - No Bad Taste

AutoDespatch SAVE 10% and get FREE P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique Auto Despatch system. Same Day Despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class! PriceMatch Guarantee! If you buy from us and then see the same product cheaper elsewhere we will refund the difference plus 10%!

SUPER STRENGTH

Antioxidant for normal mental function

Product Information Acetyl L-Carnitine is a powerful antioxidant which is believed to work particularly well when taken in combination with Alpha Lipoic Acid, as the two are thought to work in synergy within the body to offer benficial properties.

The image is for illustrative purposes only.

General

S616

Suggested/Recommended/Usage/Directions

Suggested Daily Intake Take one capsule daily as a food supplement or as directed by a healthcare professional.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acetyl L-Carnitine 500 mg by SimplySupplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acetyl L-Carnitine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acetyl L-Carnitine 500 mg by SimplySupplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Acetyl L-Carnitine

Interacts with
203 drugs
500 mg per serving

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl L-Carnitine monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Gelatin, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acetyl L-Carnitine 500 mg by SimplySupplements Drug Interactions

Want to check YOUR meds against Acetyl L-Carnitine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
203Drugs
203 Moderate

Ingredients driving the most interactions

Acetyl L-Carnitine 203

Individual Drug Interactions

The ingredients in Acetyl L-Carnitine 500 mg interact with 203 drugs. Click any drug to see the details.

1 of the 1 ingredient in Acetyl L-Carnitine 500 mg interact with drugs. Each result below shows which ingredient is responsible. Acetyl L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in Acetyl L-Carnitine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Acetyl L-Carnitine4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acetyl L-Carnitine 500 mg, from the product label.

SimplySupplements

See all SimplySupplements products
Phone Number
0800 988 0292
Pharmacist Counseling Corner

Acetyl L-Carnitine 500 mg by SimplySupplements: Common Questions

Does Acetyl L-Carnitine 500 mg by SimplySupplements interact with any medications?
Yes. Based on its ingredients, Acetyl L-Carnitine 500 mg has a known interaction with 203 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acetyl L-Carnitine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Acetyl L-Carnitine actually do?
Acetyl L-Carnitine is involved in energy production inside your cells. Research suggests it may help with age-related memory changes, Alzheimer disease, depression, nerve damage from diabetes, and alcohol use disorder — though the evidence is still developing and labeled as possibly effective.
What are the most common side effects?
Agitation, dry mouth, headache, insomnia, and reduced appetite are the most frequently reported. Some people notice a fishy odor in their urine, breath, or sweat. Gastrointestinal symptoms like nausea or diarrhea can happen but aren't more common than placebo in most studies.
Is it safe to take long-term?
It's generally well tolerated in the short term, but long-term safety hasn't been fully established, so we don't have solid data on years of use. Ask your doctor if you're thinking about taking it for extended periods.
Can I take this if I'm pregnant or breastfeeding?
For pregnancy, there isn't enough safety information to say yes or no — you'd need to discuss it with your doctor or midwife. For breastfeeding, safety is unknown, and the safer choice is to avoid it unless your doctor advises otherwise.
Does this supplement have any fillers?
Yes, it contains inactive ingredients: magnesium stearate (a flow agent), gelatin (capsule shell), and titanium dioxide (a whitening agent). These help with formulation and aren't considered active components.
Can Acetyl L-Carnitine affect how my medications work?
Yes — it interacts with antidepressants, blood thinners, and thyroid medication in particular. Use the medication checker on this page to look up your specific drugs, or ask your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acetyl L-Carnitine 500 mg label
Go deeper

The Full Monographs Behind Acetyl L-Carnitine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph →
Sources

Sources & How We Checked

Acetyl L-Carnitine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acetyl-l-carnitine 22 references
  1. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996;47:705-11. PubMed
  2. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992;49:1137-41. PubMed
  3. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. Neurology 1991;41:1726-32. PubMed
  4. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998;10:193-203. PubMed
  5. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995;16:1-4. PubMed
  6. Rai G, Wright G, Scott L, et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990;11:638-47. PubMed
  7. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  8. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003;18:61-71.. PubMed
  9. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  10. Hudson S, Tabet N. Acetyl-L-carnitine for dementia. Cochrane Database Syst Rev 2003;2:CD003158.. PubMed
  11. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  12. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D 2002;3:223-31. PubMed
  13. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  14. Sima AAF, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Diabetes Care 2005;28:89-94.
  15. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.
  16. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and a-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct;33(5):627-35.
  17. Ledinek AH, Sajko MC, Rot U. Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S86-9. PubMed
  18. Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Prog Neuropsychop PubMed
  19. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. Int J Clin Pharmacol Ther. 2015;53(11):980-6. PubMed
  20. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Australas Psychiatry. 2017;25(1):13-4.
  21. Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR. Acetyl-L-Carnitine Augmentation of Clozapine in Partial-Responder Schizophrenia: A 12-Week, Open-Label Uncontrolled Preliminary Study. Clin Neuropharmacol. 2016;39(6):277-80. PubMed
  22. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018;80(2):154-9. PubMed

See these in context on the Acetyl-l-carnitine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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