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Dietary supplement

ActivAMP AMP-K Stimulator 225 mg Ingredients & Drug Interactions

by Swanson

ActivAMP AMP-K Stimulator 225 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ActivAMP AMP-K Stimulator 225 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ActivAMP AMP-K Stimulator 225 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ActivAMP Gynostemma pentaphyllum Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ActivAMP AMP-K Stimulator 225 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with ActivAMP AMP-K Stimulator 225 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ActivAMP AMP-K Stimulator 225 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: ActivAMP Gynostemma pentaphyllum Extract, a form of jiaogulan, a plant used in traditional medicine. The capsule also contains inactive ingredients—hypromellose, brown rice powder, rice extract, and silica—which are fillers and binders.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy metabolism muscular performance body fat reduction.
  • We looked for evidence on: Athletic performance, Obesity, Stress, metabolic rate, endurance, fatigue.
  • The closest evidence on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Stress.

The evidence shows jiaogulan is possibly effective for diabetes. For athletic performance, cancer, cardiovascular disease, nonalcoholic fatty liver disease, and respiratory tract infections, the evidence we hold is not sufficient to rate whether it works.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jiaogulan appears to be well tolerated in the short term—up to about 4 months—though long-term safety hasn't been well studied. The most common side effects are diarrhea and nausea.

Some people also report dry mouth, dizziness, or trouble sleeping. Pregnancy and breastfeeding are off-limits: the safety data advises against use during pregnancy because effects on the developing baby are not established, and breastfeeding data is too limited to say it's safe.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check before taking this product if you use blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or immunosuppressants (Moderate risk of reduced effectiveness).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have diabetes and want to explore jiaogulan, talk with your doctor or pharmacist first—especially if you're already on diabetes medication, blood thinners, or immunosuppressants. Jiaogulan is not for use in pregnancy or while breastfeeding.

Check your medications against our interaction tool before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ActivAMP AMP-K Stimulator 225 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614029580
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 308446
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ActivAMP AMP-K Stimulator 225 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
087614029580
IngredientAmount% DV
ActivAMP Gynostemma pentaphyllum Extract225 mg--

Other ingredients: Hypromellose, Brown Rice, Powder, Rice extract, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports energy metabolism Helps improve muscular performance, reduce body fat and optimize metabolic activity

Energy and metabolic support

Brand IP Statement(s)

Science-backed quality since 1969

ActivAmp is a registered trademark of GE Nutrients, Inc.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule two times per day with water.

Precautions

Warning: For adults only. Keep out of reach of children.

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition especially if you are taking a blood-thinning medication or if you have an autoimmune condition.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ActivAMP AMP-K Stimulator 225 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ActivAMP AMP-K Stimulator 225 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ActivAMP AMP-K Stimulator 225 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

ActivAMP Gynostemma pentaphyllum Extract

Interacts with
327 drugs
225 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

ActivAMP Gynostemma pentaphyllum Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Brown Rice, Powder, Rice extract, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

ActivAMP AMP-K Stimulator 225 mg by Swanson Drug Interactions

Want to check YOUR meds against ActivAMP AMP-K Stimulator 225 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

ActivAMP Gynostemma pentaphyllum Extract 327

Individual Drug Interactions

The ingredients in ActivAMP AMP-K Stimulator 225 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in ActivAMP AMP-K Stimulator 225 mg interact with drugs. Each result below shows which ingredient is responsible. ActivAMP Gynostemma pentaphyllum Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in ActivAMP AMP-K Stimulator 225 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ActivAMP Gynostemma pentaphyllum Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
ActivAMP Gynostemma pentaphyllum Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ActivAMP AMP-K Stimulator 225 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

ActivAMP AMP-K Stimulator 225 mg by Swanson: Common Questions

Does ActivAMP AMP-K Stimulator 225 mg by Swanson interact with any medications?
Yes. Based on its ingredients, ActivAMP AMP-K Stimulator 225 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ActivAMP AMP-K Stimulator 225 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this supplement help my diabetes?
Jiaogulan is rated possibly effective for diabetes based on clinical research. That said, you should never replace your diabetes medication with a supplement. Talk with your pharmacist or doctor about whether adding jiaogulan makes sense alongside your current treatment.
What are the most common side effects?
Diarrhea and nausea are the most common. Some people also experience dry mouth, dizziness, or insomnia. These were reported in studies lasting up to 4 months.
Can I take this long-term?
The safety data covers short-term use—up to about 4 months. Long-term safety hasn't been well studied, so if you're thinking of taking it regularly beyond that, check with your pharmacist.
Is it safe during pregnancy?
No. The safety data advises against use during pregnancy because effects on the developing baby have not been established. If you're pregnant or planning to become pregnant, talk with your doctor before taking this or any supplement.
Can I take this while breastfeeding?
No. There isn't enough safety information about jiaogulan in breast milk, so it's best to avoid it while breastfeeding. Talk with your doctor or pharmacist if you have questions.
What is jiaogulan?
Jiaogulan, also called Gynostemma pentaphyllum, is a plant used in traditional medicine. The ActivAMP extract in this product concentrates its active compounds.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ActivAMP AMP-K Stimulator 225 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ActivAMP AMP-K Stimulator 225 mg label
Go deeper

The Full Monographs Behind ActivAMP AMP-K Stimulator 225 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

ActivAMP AMP-K Stimulator 225 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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