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Dietary supplement

Activated Broccoli Vital Extracts 350 mg Ingredients & Drug Interactions

by Solaray

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Activated Broccoli Vital Extracts 350 mg is a dietary supplement by Solaray with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, detoxification support, general heart health.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic freeze-dried Broccoli sprouts, Broccoli seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Activated Broccoli Vital Extracts 350 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 4 active ingredients.
  • “Broccoli seed extract” is listed as a grouped ingredient — the label gives one combined amount (350 mg) without saying how much of each component you get.

This product contains four active ingredients: organic freeze-dried broccoli sprouts, broccoli seed extract, sulforaphane glucosinolate, and myrosinase (an enzyme). Broccoli sprouts and sulforaphane are the compounds doing the work here — sulforaphane is a naturally occurring compound in broccoli, and myrosinase helps activate it in your digestive tract.

The remaining inactive ingredients are cellulose and calcium ascorbate (a form of vitamin C used as a preservative).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Heart health and digestion support.
  • We looked for evidence on: Hypercholesterolemia, Hypertension, Digestive health, Cardiovascular health.
  • The closest evidence on file: Sulforaphane is rated "Insufficient Reliable Evidence To Rate" for Pregnancy-induced hypertension (Natural Medicines).

The evidence for what this supplement does is sparse. Sulforaphane is possibly effective for prostate cancer, but we don't have solid data yet.

For allergic rhinitis (hay fever), asthma, liver disease, and Helicobacter pylori infection, there isn't enough reliable evidence to say whether broccoli sprout or sulforaphane work. The bottom line: this is marketed as a health supplement, but clinical proof of benefit for most conditions isn't established in the data we have.

The evidence, ingredient by ingredient Broccoli Sprout Broccoli Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli sprouts as food are generally well tolerated, but this is a concentrated supplement — less studied and with variable quality. Side effects you might notice include loose stools, diarrhea, stomach cramping, or abdominal pain, especially at higher doses.

Sulforaphane can cause bowel discomfort, heartburn, stomach upset, headache, and vomiting. Rarely, sulforaphane has been linked to seizures in people with autism and seizure disorders, and to insomnia and irritability.

One concern: raw broccoli sprouts can carry food-borne bacteria like Salmonella or E. coli if grown improperly — cooking eliminates this risk, but supplements aren't cooked.

Side effects, ingredient by ingredient Broccoli Sprout Broccoli Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sulforaphane, Broccoli Sprout.
  • The most serious interaction on file is rated Moderate.
  • For scale: 724 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any medications broken down by CYP3A4 enzymes (a major liver pathway) — sulforaphane may raise their levels. Also check drugs metabolized by CYP1A2, CYP2A6, and CYP2E1.

If you're on antiepileptic drugs or have a history of seizures, mention this supplement to your doctor first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you don't take medications metabolized by your liver, this supplement is generally well tolerated, though digestive upset is common. If you're on any prescription drugs — especially heart, blood pressure, antidepressant, or antihistamine medications — check them against the tool below before you start.

Talk to your pharmacist about whether this product makes sense alongside your current regimen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Activated Broccoli Vital Extracts 350 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280282467
Net contents 30 VegCap(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 325902
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Activated Broccoli Vital Extracts 350 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
30
UPC/BARCODE
076280282467
IngredientAmount% DV
organic freeze-dried Broccoli sprouts50 mg--
Broccoli seed extract350 mg--
Sulforaphane Glucosinolate35 mg--
Myrosinase0 NP--
Myrosinase13 mg--

Other ingredients: Cellulose, Calcium Ascorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A Brighter Way 1973

Formula

10% Sulforaphane Glucosinolates

Formulation

+ Heart health + Digestion

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified Vegan

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Activated Broccoli Vital Extracts 350 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Activated Broccoli Vital Extracts 350 mg by Solaray

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic freeze-dried Broccoli sprouts

Interacts with
187 drugs
50 mg per serving

Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammatory, and d...

Organic freeze-dried Broccoli sprouts monograph & interactions

Broccoli seed extract

Interacts with
187 drugs
350 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed extract monograph & interactions

Myrosinase

13 mg per serving Form: Brassica oleracea Italica Group

Other (inactive) ingredients: Cellulose, Calcium Ascorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Activated Broccoli Vital Extracts 350 mg by Solaray Drug Interactions

Want to check YOUR meds against Activated Broccoli Vital Extracts 350 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
723Drugs
723 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Activated Broccoli Vital Extracts 350 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic freeze-dried Broccoli sprouts2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.
Animal research shows that broccoli sprout extract can increase CYP1A2 gene expression. Also, pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to glucosinolate constituents, which are also found in broccoli sprout.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating broccoli 500 grams daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 is attributed to glucosinolate constituents, which are also found in broccoli sprout.

Likelihood Possible Evidence D

Broccoli seed extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Activated Broccoli Vital Extracts 350 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Activated Broccoli Vital Extracts 350 mg by Solaray: Common Questions

Does Activated Broccoli Vital Extracts 350 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Activated Broccoli Vital Extracts 350 mg has a known interaction with 723 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Activated Broccoli Vital Extracts 350 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Broccoli sprout as food is likely safe in pregnancy, but the concentrated supplement hasn't been well studied — your doctor should approve it first. Sulforaphane in concentrated form isn't proven safe in pregnancy, so it's best to avoid the supplement and stick to eating broccoli as food. For breastfeeding, safety data on supplement doses is lacking; talk to your doctor or pharmacist before using it.
What's sulforaphane and why is it in here?
Sulforaphane is a compound naturally found in broccoli and broccoli sprouts. It's the active ingredient researchers have been studying for potential health benefits, especially for prostate cancer. This product includes myrosinase, an enzyme that helps your body activate sulforaphane during digestion.
Can this actually prevent or treat cancer?
Sulforaphane is possibly effective for prostate cancer, but the evidence isn't conclusive yet. For other cancers, we don't have enough reliable data. Don't use this as a substitute for cancer treatment — talk to your oncologist if you're interested in adding it to your plan.
Will this give me diarrhea or stomach problems?
Yes, it's fairly common. Loose stools, diarrhea, abdominal cramping, and stomach upset have been reported, especially at higher doses. Start with a low dose and see how you tolerate it. If problems persist, cut back or stop and tell your pharmacist.
What if the broccoli sprouts are contaminated with bacteria?
Improperly grown broccoli sprouts can carry bacteria like Salmonella or E. coli. Cooking kills these germs, but supplements aren't cooked. Choose a reputable brand and check whether their product has been tested for safety.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Activated Broccoli Vital Extracts 350 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Activated Broccoli Vital Extracts 350 mg label
Sources

Sources & How We Checked

Activated Broccoli Vital Extracts 350 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli Sprout 8 references
  1. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  2. Pezdirc KB, Hure AJ, Blumfield ML, Collins CE. Listeria monocytogenes and diet during pregnancy; balancing nutrient intake adequacy v. adverse pregnancy outcomes. Public Health Nutr 2012;15(12):2202-9.
  3. Gorski L, Flaherty D, Duhe JM. Comparison of the stress response of Listeria monocytogenes strains with sprout colonization. J Food Prot 2008;71(8):1556-1562. PubMed
  4. Fahey JW, Ourisson PJ, Degnan FH. Pathogen detection, testing, and control in fresh broccoli sprouts. Nutr J 2006;5:13. PubMed
  5. Rajkowski KT, Boyd G, Thayer DW. Irradiation D-values for Escherichia coli O157:H7 and Salmonella sp. on inoculated broccoli seeds and effects of irradiation on broccoli sprout keeping quality and seed viability. J Food Prot 2003;66(5):760-766. PubMed
  6. Yoshida K, Ushida Y, Ishijima T, et al. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World J Gastroenterol. 2015;21(35):10091-103. PubMed
  7. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  8. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli Sprout monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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