Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

AdrenaMed Ingredients & Drug Interactions

by NuMedica

AdrenaMed label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AdrenaMed against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AdrenaMed is a dietary supplement by NuMedica with 6 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,332 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Rhodiola Root Extract, Cordyceps Mycelium Extract, American Ginseng Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against AdrenaMed by NuMedica

Ask about any prescription or over-the-counter medication and we check it for interactions with AdrenaMed by NuMedica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of AdrenaMed by NuMedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

AdrenaMed has six active ingredients. Vitamin B6 supports energy and nerve function.

Pantothenic acid helps your body break down fats and carbohydrates. Para-Aminobenzoic Acid is included but we hold no interaction data for it.

Rhodiola root extract is an herbal adaptogen. American ginseng root extract is traditionally used to support immune function and energy.

Cordyceps mycelium extract is a fungal product also marketed for energy and stamina. The capsule also contains inactive ingredients (fillers and binders): hydroxypropyl methylcellulose, microcrystalline cellulose, ascorbyl palmitate, L-leucine, and bamboo extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support stress response and energy.
  • We looked for evidence on: Anxiety, Athletic performance, Chronic fatigue syndrome (CFS), Cognitive function, Depression, Fatigue — and 4 related terms.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Fatigue.
  • Also on file: Pantothenic Acid is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Athletic performance, Chronic fatigue syndrome (CFS), Depression.

The evidence for most of these ingredients in AdrenaMed is limited. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and possibly effective for pregnancy-related nausea and vomiting—though use in pregnancy must be guided by a doctor.

For the other conditions (like high homocysteine), the data rates it likely effective or possibly effective. Pantothenic acid is effective for pantothenic acid deficiency, but for other uses we hold insufficient evidence.

For rhodiola, American ginseng, and cordyceps, the evidence we have rates them at insufficient evidence for most of the claims made about them, though American ginseng is possibly effective for upper respiratory infections. The bottom line: effectiveness for adrenal support or energy specifically is not established in our data.

The evidence, ingredient by ingredient Vitamin B6 Pantothenic Acid Rhodiola American Ginseng Cordyceps

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, but high doses over time can cause nerve damage (sensory neuropathy). Common side effects at any dose include headache, nausea, and heartburn.

Pantothenic acid is generally well tolerated orally and may cause diarrhea. Rhodiola is generally well tolerated for short-term use, but long-term safety isn't well studied; adverse effects include dizziness and changes in saliva.

American ginseng is generally well tolerated short-term in healthy adults but can cause headache, and long-term safety is unclear. Cordyceps is generally well tolerated for up to a year, with uncommon side effects like diarrhea, constipation, and abdominal discomfort; there is one rare case report of liver inflammation.

Rhodiola, American ginseng, and cordyceps should all be avoided during pregnancy and breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Vitamin B6 Pantothenic Acid Rhodiola American Ginseng Cordyceps

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Cordyceps, Rhodiola, Vitamin B6, American Ginseng.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners like warfarin (Major concern with American ginseng), blood pressure medications, diabetes drugs, seizure medications (phenobarbital, phenytoin), heart rhythm drugs like amiodarone, monoamine oxidase inhibitors (older antidepressants), immune-suppressant drugs, and drugs your liver metabolizes (including losartan) all have documented interactions. If you take levodopa for Parkinson's and are not on carbidopa, that's also a concern.

Check your prescriptions in the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, seizure medications, blood pressure drugs, diabetes medications, or monoamine oxidase inhibitors, check your exact prescriptions with the tool below before taking this product. Rhodiola and American ginseng have not been well studied long-term, and several ingredients should be avoided in pregnancy and while breastfeeding.

Talk to your pharmacist before starting, especially if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AdrenaMed, straight from the product label.

Brand NuMedica
Barcode (UPC) 812527010581
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 323488
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AdrenaMed by NuMedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
812527010581
IngredientAmount% DV
Vitamin B650 mg2941%
Pantothenic Acid50 mg1000%
Para-Aminobenzoic Acid25 mg--
Rhodiola Root Extract100 mg--
American Ginseng Root Extract200 mg--
Cordyceps Mycelium Extract400 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Ascorbyl Palmitate, L-Leucine, Bamboo Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule twice per day or as directed by your healthcare practitioner.

Formula

AdrenaMed is a concentrated adaptogenic herbal and vitamin formula featuring standardized extracts of cordyceps, rhodiola and ginseng - all designed to support the stress response. Additionally, this formula contains select B vitamins involved in adrenal hormone production to support adrenal stress.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: If pregnant or lactating, please consult with your healthcare practitioner before use.

Keep out of reach of children.

Storage

Storage: Keep tightly closed in a cool, dry place.

Formulation

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Vegetarian

Gluten-free

Professional quality formula Support for adrenal stress Adaptogenic stress formula

Seals/Symbols

cGMP Third-Party Certified Facility

Brand IP Statement(s)

NuMedica Advancing Nutrition

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AdrenaMed by NuMedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AdrenaMed label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AdrenaMed by NuMedica

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
50 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Pantothenic Acid

No known
interactions
50 mg per serving Form: D-Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Para-Aminobenzoic Acid

25 mg per serving

Rhodiola Root Extract

Interacts with
1,271 drugs
100 mg per serving Form: Rosavins, Salidrosides

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola Root Extract monograph & interactions

American Ginseng Root Extract

Interacts with
217 drugs
200 mg per serving Form: Panax quinquefolius Root Extract

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...

American Ginseng Root Extract monograph & interactions

Cordyceps Mycelium Extract

Interacts with
249 drugs
400 mg per serving Form: Adenosine, Cordycepic Acid, Cordyceps sinesis Mycelium Extract

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Mycelium Extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Ascorbyl Palmitate, L-Leucine, Bamboo Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

AdrenaMed by NuMedica Drug Interactions

Want to check YOUR meds against AdrenaMed?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,332Drugs
2 Major 742 Moderate 588 Minor

Ingredients driving the most interactions

Rhodiola Root Extract 1,271
Cordyceps Mycelium Extract 249
American Ginseng Root Extract 217
Vitamin B6 210

Individual Drug Interactions

The ingredients in AdrenaMed interact with 1,332 drugs. Click any drug to see the details.

4 of the 6 ingredients in AdrenaMed interact with drugs. Each result below shows which ingredient is responsible. Rhodiola Root Extract Cordyceps Mycelium Extract American Ginseng Root Extract Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in AdrenaMed with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola Root Extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola Root Extract full monograph & interactions

Cordyceps Mycelium Extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mycelium Extract full monograph & interactions

American Ginseng Root Extract4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
American Ginseng Root Extract full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AdrenaMed, from the product label.

NuMedica

See all NuMedica products
Name
NuMedica LLC
Street Address
9503 E. 55th Place
City
Tulsa
State
OK
ZipCode
74145
Phone Number
800.869.8100
Web Address
www.numedica.com
Pharmacist Counseling Corner

AdrenaMed by NuMedica: Common Questions

Does AdrenaMed by NuMedica interact with any medications?
Yes. Based on its ingredients, AdrenaMed has a known interaction with 1,332 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AdrenaMed contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Rhodiola, American ginseng, and cordyceps should be avoided during pregnancy and breastfeeding—there isn't enough safety data. Vitamin B6 and pantothenic acid in prenatal amounts are fine, but talk with your doctor or pharmacist before taking high-dose supplements of any ingredient. Since AdrenaMed is a combination product, it's best to check with your provider for personalized advice.
Is vitamin B6 in this product safe at high doses?
Vitamin B6 is well tolerated under 100 mg daily. High doses over time can damage nerves (sensory neuropathy), particularly at doses over 1,000 mg daily or total intakes over 1,000 grams. Common side effects include headache, nausea, and heartburn. Check the dose of B6 in this product and discuss it with your pharmacist if you're taking high-dose B6 elsewhere.
What is American ginseng in this product supposed to do?
American ginseng is included to support immune function and energy. The only use rated possibly effective in our data is upper respiratory infection (common cold). For other uses marketed on supplement labels, the evidence we hold is either insufficient or not established.
Will this product affect my seizure medication?
Yes—vitamin B6 at high doses may reduce the levels and effectiveness of phenobarbital (Luminal) and phenytoin (Dilantin). Tell your pharmacist if you take either of these medications before starting AdrenaMed.
What side effects are most common?
Vitamin B6 may cause headache, nausea, or heartburn. Cordyceps can cause diarrhea, constipation, or abdominal discomfort. Rhodiola may cause dizziness or changes in saliva production. American ginseng may cause headache. Most effects are mild and uncommon at recommended doses.
Does this interact with my blood pressure or diabetes medication?
Yes. Vitamin B6 and rhodiola both lower blood pressure, so together with blood pressure drugs they might lower it too much. Rhodiola and American ginseng may increase blood sugar lowering with diabetes drugs, raising the risk of low blood sugar. Use the medication checker below to verify your specific drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AdrenaMed label
Go deeper

The Full Monographs Behind AdrenaMed’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph →
Sources

Sources & How We Checked

AdrenaMed's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
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American Ginseng 12 references
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Cordyceps 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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