Advanced Immune Support Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Advanced Immune Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Advanced Immune Support is a dietary supplement by The Vitamin Shoppe with 6 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 382 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mushroom mycelial extract, Astragalus, Agaricus blazei mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Advanced Immune Support by The Vitamin Shoppe
Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Immune Support by The Vitamin Shoppe — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Advanced Immune Support by The Vitamin Shoppe
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Advanced Immune Support contains six ingredients, three of which are active: maitake mushroom mycelial extract, astragalus, and agaricus blazei mushroom. The product also contains Active Hexose Correlated Compound, which is a blend of component ingredients listed separately.
The remaining three ingredients are inactive fillers: rice flour, vegetable cellulose, magnesium stearate, microcrystalline cellulose, and candelilla wax.
Does it work?
Not established
The evidence for these ingredients isn't established in our data. Maitake mushroom, astragalus, and agaricus blazei mushroom all have insufficient reliable evidence to rate them for allergies, anemia, cancer, diabetes control, asthma, angina, or the other conditions in the literature we hold.
That doesn't mean they don't work — it means the research to prove it isn't solid enough for us to call.
How safe is it?
Well-documented data
Maitake mushroom is generally well tolerated as a food, though concentrated supplement safety hasn't been fully studied. The most common side effects in trials were stomach upset, including diarrhea and epigastric pain (pain below your ribs), plus nausea in a small number of participants.
A rare allergic rash was reported in one patient and cleared on its own. Astragalus is generally well tolerated short-term in healthy adults, but human safety data is limited; dizziness and rash have been reported rarely in some studies.
Agaricus mushroom is generally well tolerated, with the most common side effects being abdominal discomfort, diarrhea, and nausea. Rare but serious reports exist of allergic reactions, liver injury, and lung inflammation (interstitial lung disease), including three cases of severe liver damage in women with cancer taking supplements.
The safety data advises against this product during pregnancy and while breastfeeding — there isn't enough data to know either way.
Meds to double-check
Moderate interaction found
Double-check this product before starting if you take blood thinners like warfarin, blood pressure medications, diabetes drugs, immunosuppressants, lithium, or cyclophosphamide (a chemotherapy drug). All carry Moderate-severity risks.
No interactions are documented for the other ingredients we could not check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is for people looking to support their immune system who don't take blood thinners, blood pressure drugs, diabetes medications, immunosuppressants, lithium, or certain chemotherapy drugs. If you take any of those, or if you're pregnant or breastfeeding, talk with your pharmacist before starting.
The evidence for whether it actually works isn't solid, so manage expectations.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Advanced Immune Support, straight from the product label.
| Brand | The Vitamin Shoppe |
|---|---|
| Barcode (UPC) | 766536042494 |
| Net contents | 60 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 10, 2014 |
| DSLD ID | 37523 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Advanced Immune Support by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Microcrystalline Cellulose | 0 NP | -- |
| Candelilla Wax | 0 NP | -- |
| Active Hexose Correlated Compound | 500 mg | -- |
| Mushroom mycelial extract | 0 NP | -- |
| Cyclodextrin | 0 NP | -- |
| Astragalus | 500 mg | -- |
| Agaricus blazei mushroom | 200 mg | -- |
Other ingredients: Rice Flour, Vegetable Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Does not contain: Corn, Sugar, Salt, Soy, Dairy, Fish, Animal Derivatives, Preservatives, Artificial Colors or Flavors.
dairy free soy free nut free
Precautions
WARNING: Do not use if you are pregnant, nursing, or planning to have surgery. Please consult your physician prior to use if you have any medical condition or are taking any medication especially anticoagulants.
KEEP OUT OF REACH OF CHILDREN.
TAMPER EVIDENT Do not use if outer seal is broken or missing.
Contains: Wheat.
Formula
Contains: Wheat.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Suggested/Recommended/Usage/Directions
DIRECTIONS: As a dietary supplement, take two (2) veggie capsules daily, preferably with meals.
Storage
STORE IN A COOL, DRY PLACE.
Brand IP Statement(s)
AHCC(R) is a registered trademark of Amino Up Chemical Company, Ltd.
General Statements
Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.
specialty
immunity
{veggie capsule} actual size
General
Item No. VS-4249 1776988 HO 1
FDA Statement of Identity
dietary supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Advanced Immune Support by The Vitamin Shoppe label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Advanced Immune Support by The Vitamin Shoppe
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Active Hexose Correlated Compound
- › Microcrystalline Cellulose
- › Candelilla Wax
- › Mushroom mycelial extract
- › Cyclodextrin
Astragalus
Interacts with208 drugs
Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...
Astragalus monograph & interactionsAgaricus blazei mushroom
Interacts with86 drugs
Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...
Agaricus blazei mushroom monograph & interactionsOther (inactive) ingredients: Rice Flour, Vegetable Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Advanced Immune Support by The Vitamin Shoppe Drug Interactions
HelloPharmacist Interaction Report
Advanced Immune Support by The Vitamin Shoppe contains three active ingredients we can check for interactions, and together they interact with a substantial number of medications.
The most serious concern is with blood thinners like warfarin — maitake mushroom may increase their effect, raising your bleeding risk. Altogether, these interactions span 375 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Maitake mushroom also pairs cautiously with blood pressure drugs (antihypertensive drugs) and diabetes medications, both at Moderate severity. The risk is that it could lower your blood pressure or blood sugar too far.
Astragalus carries similar warnings: it may interfere with immunosuppressants (drugs that tamp down your immune system after transplant, for example), increase lithium levels if you take it for bipolar disorder, potentially blunt cyclophosphamide (a chemotherapy drug), and lower blood sugar alongside diabetes medications — all Moderate severity. Agaricus mushroom also interacts with diabetes medications at Moderate severity.
We could not check three other ingredients in this formula: microcrystalline cellulose, candelilla wax, and cyclodextrin. Run your exact medications through the checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Advanced Immune Support?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Advanced Immune Support interact with 382 drugs. Click any drug to see the details.
3 of the 6 ingredients in Advanced Immune Support interact with drugs. Each result below shows which ingredient is responsible. Mushroom mycelial extract Astragalus Agaricus blazei mushroom
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
AstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Acarbose interactionMushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Acarbose interactionAgaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Acetohexamide interactionAstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Acetohexamide interactionAgaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Acetohexamide interactionAdalimumabHumira
How Adalimumab interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
AstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Albiglutide interactionMushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Albiglutide interactionAgaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
AstragalusImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Alogliptin interactionAgaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Alogliptin interactionAstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
AstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Alogliptin, Metformin interactionMushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Alogliptin, Metformin interactionAgaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Advanced Immune Support — through 3 ingredients. Tap an ingredient for the detail:
Agaricus Blazei MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Blazei Mushroom + Alogliptin, Pioglitazone interactionAstragalusAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Alogliptin, Pioglitazone interactionMushroom Mycelial ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mushroom Mycelial Extract + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Advanced Immune Support — through 1 ingredient. Tap an ingredient for the detail:
Mushroom Mycelial ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Mushroom Mycelial Extract + Ammonium Chloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Advanced Immune Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Mushroom mycelial extract
Antidiabetes Drugs
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.
Antihypertensive Drugs
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Warfarin (Coumadin)
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.
Astragalus
Antidiabetes Drugs
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.
Cyclophosphamide
Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.
Immunosuppressants
Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.
Lithium
Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.
Agaricus blazei mushroom
Antidiabetes Drugs
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.
Brand information
Manufacturer and brand details for Advanced Immune Support, from the product label.
The Vitamin Shoppe
See all The Vitamin Shoppe products- Name
- Vitamin Shoppe, Inc.
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-800-223-1216
- Web Address
- www.vitaminshoppe.com
Advanced Immune Support by The Vitamin Shoppe: Common Questions
Does Advanced Immune Support by The Vitamin Shoppe interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
What are the most common side effects?
Does this actually work for immune support?
What's maitake mushroom supposed to do?
Why are there so many drug interactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Advanced Immune Support is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Advanced Immune Support’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Maitake Mushroom
Interacts with 260 drugsMaitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...
Read the full Maitake Mushroom monograph → Herb & supplement monographAstragalus
Interacts with 208 drugsAstragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...
Read the full Astragalus monograph → Herb & supplement monographAgaricus Mushroom
Interacts with 86 drugsAgaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...
Read the full Agaricus Mushroom monograph →Sources & How We Checked
Advanced Immune Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maitake Mushroom 8 references
- Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
- Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
- Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
- Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
- Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
- Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
- Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
- Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed
Astragalus 13 references
- Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
- Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
- Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
- Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
- Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
- Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
- Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
- Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
- Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
- Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
- Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
- Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
- Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):
Agaricus Mushroom 5 references
- Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
- Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
- Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
- Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
- Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.
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