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Dietary supplement

Agmatine 500 Milligrams Ingredients & Drug Interactions

by NutraBio

Agmatine 500 Milligrams label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine 500 Milligrams is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine 500 Milligrams by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine 500 Milligrams by NutraBio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agmatine 500 Milligrams by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Agmatine 500 Milligrams is a straightforward single-ingredient supplement: each capsule contains 500 mg of agmatine sulfate. Agmatine is a compound naturally produced in your body from the amino acid arginine.

It's wrapped in a vegetable capsule (the inactive ingredient that holds the powder).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: pre- and post-workout support.
  • We looked for evidence on: Athletic performance, Muscle strength, Exercise performance, Muscle pumps, Workout recovery.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence backing agmatine for any health purpose isn't yet established in our data. The supplement has been studied for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder — but in each case, the evidence is insufficient to draw a reliable conclusion.

If you're considering agmatine for any of these reasons, talk with your doctor or pharmacist about what the current research shows and whether it makes sense for you.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. The most common side effects reported in small studies are diarrhea, indigestion (dyspepsia), and nausea — mild to moderate diarrhea and nausea showed up in a few patients taking higher doses (3.56 grams daily) and cleared up once they stopped.

However, long-term safety in people hasn't been well studied, so we don't have much data on what happens with extended use. If you're pregnant or breastfeeding, there isn't enough safety data, so it's best to avoid agmatine.

Talk with your doctor or pharmacist about your individual situation before taking it.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on blood pressure medication, agmatine could lower your pressure further — a Moderate concern. If you take diabetes medication, agmatine might lower your blood sugar too much, also Moderate.

Check your exact medications with the tool on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine might interest you if you've read about it for conditions like anxiety or cognitive support — but the evidence doesn't yet confirm it works for any of these. The real thing to watch for is whether you take blood pressure or diabetes medications; if you do, check with your pharmacist first.

Short-term use looks okay for most people, but we don't know much about long-term safety.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine 500 Milligrams, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908517465
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 248184
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine 500 Milligrams by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
Servings per container
90
UPC/BARCODE
649908517465
IngredientAmount% DV
Agmatine Sulfate500 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take on workout & non-workout days. Non-Workout days: Take 1-2 servings daily with food. Workout days: Take 20-40 minutes before training.

Formulation

Vegetarian

Gluten Free Non-GMO Lactose Free No exipients, no fillers, allergen free, no artificial color, flavor or sweetener, no preservatives, no starch, no sugar, no soy, no wheat, no yeast, no fish, no milk, sodium free.

Nitric oxide booster HPLC lab tested for potency

Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of reach of children.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Discontinue use two weeks prior to surgery.

General Statements

Since 1996 Manufactured in our GMP & FDA inspected facility FDA Registration: 16906175560

Dietary Supplement

Seals/Symbols

Made in USA -with ingredients sourced worldwide-

OU (Kosher)

Formula

Pure Agmatine Sulfate

OU (Kosher)

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine 500 Milligrams by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine 500 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine 500 Milligrams by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine 500 Milligrams by NutraBio Drug Interactions

Want to check YOUR meds against Agmatine 500 Milligrams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Agmatine 500 Milligrams interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine 500 Milligrams interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine 500 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine 500 Milligrams, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

Agmatine 500 Milligrams by NutraBio: Common Questions

Does Agmatine 500 Milligrams by NutraBio interact with any medications?
Yes. Based on its ingredients, Agmatine 500 Milligrams has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine 500 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data for either pregnancy or breastfeeding. The advice is to avoid it in both cases. Talk with your doctor or pharmacist about your situation and any alternatives that might work better.
What are the side effects?
The most common ones reported are diarrhea, indigestion, and nausea. In small studies, these were mild to moderate and went away when people stopped taking it. Long-term side effects haven't been well studied.
Does agmatine actually work for anxiety (or Alzheimer disease, or autism)?
The evidence we have isn't strong enough to say either way right now. Agmatine has been studied for all three of these conditions, but none of them have sufficient reliable evidence yet. Ask your doctor what's currently known and whether it's worth trying for your situation.
What is agmatine?
It's a compound your body makes naturally from the amino acid arginine. In supplement form, it comes from outside sources and is meant to boost levels in your bloodstream and tissues.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine 500 Milligrams is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine 500 Milligrams label
Go deeper

The Full Monographs Behind Agmatine 500 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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