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Dietary supplement

Agmatine Sulfate 550 mg Ingredients & Drug Interactions

by Hard Rhino

Agmatine Sulfate 550 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine Sulfate 550 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine Sulfate 550 mg is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine Sulfate 550 mg by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine Sulfate 550 mg by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agmatine Sulfate 550 mg by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: agmatine sulfate, at 550 mg per capsule. The only other ingredient is vegetarian cellulose, which is the capsule material itself.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promotes nitric oxide production and muscle recovery.
  • We looked for evidence on: Athletic performance, Muscle strength, exercise endurance, post-workout recovery, blood flow.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine isn't established in the data we hold. Our monograph lists six conditions—alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder—and for each one, the rating is insufficient reliable evidence to rate.

That means the research so far either hasn't been done, isn't robust enough, or is too mixed to draw a clear conclusion. If you're considering this for a specific reason, it's worth talking with your pharmacist or doctor about what the current science actually supports.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. The most common side effects in small clinical trials were diarrhea, upset stomach (dyspepsia), and nausea—and they typically showed up within 2 to 3 days.

In one small study, 3 out of 24 people on a daily dose of 3.56 grams reported mild-to-moderate diarrhea and nausea, which resolved once they stopped taking it. The catch is that long-term safety in humans hasn't been well studied, so we don't know what happens if you take this for months or years.

There isn't enough safety data to recommend agmatine during pregnancy or while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Hard Rhino's Agmatine Sulfate, double-check any antihypertensive drugs (blood pressure medications) you take—agmatine might lower your blood pressure too much. Also screen any antidiabetes drugs (blood sugar medications) you're on, since agmatine theoretically raises the risk of low blood sugar.

Both interactions are rated Moderate severity. Use the medication checker on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine is a single-ingredient supplement with no clear established benefit in the conditions listed in our data. It's generally well tolerated short-term, but it can interact with blood pressure and blood sugar medications—and we don't know much about long-term safety.

If you take any antihypertensive or antidiabetes drugs, check your specific medications before you start. And if you're pregnant or breastfeeding, avoid this one.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine Sulfate 550 mg, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 798711499496
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71678
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine Sulfate 550 mg by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
798711499496
IngredientAmount% DV
Agmatine Sulfate550 mg--

Other ingredients: Vegetarian Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one serving (1 capsule). Taken once in the morning on an empty stomach and/or again one hour prior to work out for best results.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if seal is broken.

General Statements

Promotes increased Nitric Oxide (N.O.) production Aids in post-recovery and muscle repair Supports muscle pump and mass

Formulation

Allergens: This product contains no soy, dairy & byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.

This contains non-GMO ingredients

Storage

Storage: Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine Sulfate 550 mg by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine Sulfate 550 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine Sulfate 550 mg by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
550 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Vegetarian Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine Sulfate 550 mg by Hard Rhino Drug Interactions

Want to check YOUR meds against Agmatine Sulfate 550 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Agmatine Sulfate 550 mg interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine Sulfate 550 mg interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine Sulfate 550 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine Sulfate 550 mg, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
Street Address
1607 West Whispering Wind Drive
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866) 961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

Agmatine Sulfate 550 mg by Hard Rhino: Common Questions

Does Agmatine Sulfate 550 mg by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Agmatine Sulfate 550 mg has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine Sulfate 550 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does agmatine do in the body?
Agmatine is a compound that animal research suggests can modestly lower blood pressure and heart rate, and may have mild effects on blood sugar. However, reliable evidence for what it actually does in people—and whether it helps any specific condition—isn't established in our data.
What are the most common side effects?
In small clinical studies, the most common side effects were diarrhea, upset stomach, and nausea. These typically appeared within 2 to 3 days of starting and went away once people stopped taking it. Most people tolerated it without problems short-term.
Is it safe to take long-term?
We don't have solid data on long-term safety in humans. Short-term use appears generally well tolerated, but if you're thinking about taking this for months or longer, that's a good question for your pharmacist or doctor.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data, so it's best to avoid agmatine during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you have questions specific to your situation.
Does this product have any fillers?
The only other ingredient is vegetarian cellulose, which is the material the capsule is made from. There are no added fillers or binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine Sulfate 550 mg label
Go deeper

The Full Monographs Behind Agmatine Sulfate 550 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine Sulfate 550 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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