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Dietary supplement

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit Ingredients & Drug Interactions

by Bayer

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit is a dietary supplement by Bayer with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 168 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium Carbonate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer

Ask about any prescription or over-the-counter medication and we check it for interactions with Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: calcium carbonate, a common antacid that neutralizes stomach acid and is also used to treat low blood calcium and raise potassium levels in kidney failure. The remaining ingredients are inactive — colorants, sweeteners, binders, and flavoring — that give the chew its texture and taste.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: fast relief of heartburn and acid indigestion.
  • We looked for evidence on: Dyspepsia, gastroesophageal reflux disease, acid reflux, indigestion.
  • The strongest evidence on file: Calcium is rated "Effective" for Dyspepsia (Natural Medicines).

Calcium carbonate in this product is effective for heartburn and indigestion (dyspepsia), kidney failure, low blood calcium (hypocalcemia), and high potassium levels (hyperkalemia). It's also likely effective for osteoporosis.

The evidence supports its use for these purposes when taken as directed.

The evidence, ingredient by ingredient Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium carbonate is generally well tolerated at recommended doses. The most common side effects are belching, constipation, diarrhea, bloating, and stomach upset.

Rare but serious concerns include kidney stones and a condition called calciphylaxis. Very high doses — beyond what's recommended — carry a theoretical risk of increased prostate cancer and cardiovascular concerns, though research on these points is mixed and often limited to doses well above typical antacid use.

Ca adequate calcium during pregnancy supports fetal development; stay within the amounts your doctor recommends. During breastfeeding, calcium needs can be met through this product at recommended amounts — check with your provider if you have questions about your personal situation.

Side effects, ingredient by ingredient Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take dolutegravir (Tivicay) or elvitegravir (Vitekta) for HIV — calcium cuts their blood levels significantly. Also flag ceftriaxone (Rocephin) by IV, levothyroxine (Synthroid) for thyroid disease, sotalol (Betapace) for heart rhythm, diltiazem (Cardizem) for blood pressure, calcipotriene (Dovonex) for psoriasis, or raltegravir (Isentress) for HIV.

Timing adjustments or avoiding the combination may be needed depending on your drug.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This antacid works well for heartburn and stomach upset, and the calcium is useful if you also need extra calcium intake. However, if you take HIV medications like dolutegravir or elvitegravir, an antibiotic like ceftriaxone, thyroid hormone, or heart medications, you need to talk with your doctor or pharmacist first — timing or spacing matters, or the interaction may be too risky to manage.

Otherwise, it's generally safe at recommended doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit, straight from the product label.

Brand Bayer
Barcode (UPC) 016500563815
Net contents 150 Chewable Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239710
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Not Present
Maximum serving Sizes:
1 Not Present
UPC/BARCODE
016500563815
IngredientAmount% DV
Calcium Carbonate750 mg--

Other ingredients: Acacia, Carmine, Carnauba Wax, Citric Acid, Corn Starch, Corn Syrup, DL-Alpha-Tocopherol, FD&C Blue #1 Aluminum Lake, FD&C Red #40 Aluminum Lake, FD&C Yellow #5 Lake, FD&C Yellow #6, FD&C Yellow #6 Aluminum Lake, FD&C Yellow #6 Lake, Flavors, hydrogenated Coconut Oil, Hydrogenated Vegetable Oil, Lecithin, Medium Chain Triglycerides, Methyl Paraben, modified Starch, Phosphoric Acid, pregelatinized modified Starch, Propyl Paraben, Propylene Glycol, Shellac, Sodium Benzoate, Sorbic Acid, Sorbitol, Sugar, Titanium Dioxide, Water, White Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not use if safety seal bearing "sealed for your protection" under cap is torn or missing.

Warnings Do not use if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor or pharmacist before use if you are presently taking a prescription drug. Antacids may interact with certain prescription drugs.

When using this product Do not take more than 5 chewable tablets in a 24-hour period Do not use the maximum dosage of this product for more than 2 weeks, except under the advice and supervision of a physician Constipation may occur

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

General Statements

Enjoy the relief!

New size!

Questions or comments? 1-800-986-0369 (Mon-Fri 9AM-5PM EST)

Brand IP Statement(s)

Bayer, the Bayer Cross, Alka-Seltzer and ReliefChews are registered trademarks of Bayer.

Formulation

Made in the USA of US & imported materials

Fast powerful relief of Heartburn Acid indigestion Upset stomach

Uses for the relief of: Acid indigestion Heartburn Sour stomach Upset stomach associated with these symptoms

Formula

Calcium Carbonate / Antacid

Other information Each chewable tablet contains: calcium 330 mg Contains FD&C Yellow No. 5 (Tartrazine) as a color additive

Suggested/Recommended/Usage/Directions

Directions Adults and children 12 years and over: fully chew then swallow 1 or 2 chewable tablets as symptoms occur, or as directed by a doctor Children under 12 years: consult a doctor Do not take more than 5 chewable tablets in a 24-hour period

Storage

Store at room temperature. Avoid humidity. Close cap tightly after use

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Not Present Dosage formTablet Or Pill Amounts shown are per serving.

Calcium Carbonate

Interacts with
168 drugs
750 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium Carbonate monograph & interactions

Other (inactive) ingredients: Acacia, Carmine, Carnauba Wax, Citric Acid, Corn Starch, Corn Syrup, DL-Alpha-Tocopherol, FD&C Blue #1 Aluminum Lake, FD&C Red #40 Aluminum Lake, FD&C Yellow #5 Lake, FD&C Yellow #6, FD&C Yellow #6 Aluminum Lake, FD&C Yellow #6 Lake, Flavors, Hydrogenated Coconut Oil, Hydrogenated Vegetable Oil, Lecithin, Medium Chain Triglycerides, Methyl Paraben, Modified Starch, Phosphoric Acid, Pregelatinized modified Starch, Propyl Paraben, Propylene Glycol, Shellac, Sodium Benzoate, Sorbic Acid, Sorbitol, Sugar, Titanium Dioxide, Water, White Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer Drug Interactions

Want to check YOUR meds against Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
168Drugs
7 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Calcium Carbonate 168

Individual Drug Interactions

The ingredients in Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit interact with 168 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit interact with drugs. Each result below shows which ingredient is responsible. Calcium Carbonate

Each ingredient & the kinds of drugs it affects

For each ingredient in Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium Carbonate18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium Carbonate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit, from the product label.

Bayer

See all Bayer products
Name
Bayer HealthCare LLC
City
Whippany
State
NJ
ZipCode
07981
Phone Number
1-800-986-0369
Pharmacist Counseling Corner

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer: Common Questions

Does Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit by Bayer interact with any medications?
Yes. Based on its ingredients, Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit has a known interaction with 168 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does calcium carbonate do in this product?
Calcium carbonate is an antacid — it neutralizes stomach acid to relieve heartburn and indigestion. It also supplies dietary calcium, which your body needs for bones, muscles, and nerves.
What are the most common side effects?
Belching, constipation, diarrhea, bloating, and mild stomach upset are the typical side effects when taken orally. These are usually minor and go away with continued use or a change in dose.
Is it safe to take during pregnancy?
Adequate calcium is important during pregnancy. The data supports its safety in pregnancy when you stay within the amounts your doctor recommends — talk with your doctor or midwife about the right dose for you.
Can I take this with my thyroid medication?
Calcium can bind to thyroid hormone and reduce how much your body absorbs, making the medication less effective. If you take levothyroxine (Synthroid), separate it from this product by at least 4 hours — take one in the morning and the other later in the day.
Is there a concern with high doses?
Yes. Very high doses beyond the recommended daily amount carry theoretical risks for kidney stones and, in rare cases, may link to prostate cancer or cardiovascular concerns. Stick to the label dose and don't exceed recommended daily limits.
Can I take this with my blood pressure or heart medication?
That depends on which medication you take. Calcium can reduce how well some heart drugs work — diltiazem (Cardizem) and sotalol (Betapace) are affected. Check with your pharmacist or doctor before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit label
Go deeper

The Full Monographs Behind Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Alka-Seltzer Extra Strength Heartburn Relief Chews Assorted Fruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 62 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  24. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
  25. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
  27. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
  28. Tavani A, Bertuccio P, Bosetti C, et al. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 2005;48:27-33. PubMed
  29. Giovannucci E, Liu Y, Stampfer MJ, Willett WC. A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:203-10. PubMed
  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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