Major interaction on record — check this product against your medications before combining. Based on 13 of 17 ingredients. Check your meds →
Dietary supplement

Amino Acid Complex Ingredients & Drug Interactions

by Wonder Labs

Amino Acid Complex label
See full label image
Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino Acid Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amino Acid Complex is a dietary supplement by Wonder Labs with 17 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 439 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine, L-Tyrosine, L-Phenylalanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino Acid Complex by Wonder Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino Acid Complex by Wonder Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amino Acid Complex by Wonder Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 17 of its 17 active ingredients.
  • “Collagen” is listed as a grouped ingredient — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

Amino Acid Complex by Wonder Labs contains 17 active amino acids: L-leucine, L-arginine, L-alanine, L-isoleucine, L-methionine, L-tyrosine, L-phenylalanine, L-valine, L-proline, L-glycine, L-ornithine hydrochloride, L-aspartic acid, L-histidine, L-glutamic acid, L-threonine, L-lysine, and L-serine. These are protein building blocks your body uses to build and repair tissue, create enzymes, and support nervous-system function.

The tablets also contain inactive ingredients—veg. cellulose, silica, and veg. magnesium stearate—which are the capsule material and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: nutritional supplement and amino acid support.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle strength, Muscle fatigue, Fatigue, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Possibly Effective" for Herpes labialis (cold sores).
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

The evidence for this product's blend is not established in the data we hold. Individual amino acids show mixed evidence for specific uses: L-tyrosine is possibly effective for cognitive function and memory; L-lysine is possibly effective for cold sores; L-arginine, L-phenylalanine, L-ornithine, and others show insufficient evidence for most claimed uses.

Without clinical trials of the formula itself, we cannot say what to expect from taking all these ingredients together.

The evidence, ingredient by ingredient L-arginine Alpha-alanine Methionine Tyrosine Phenylalanine Proline Glycine Ornithine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 13 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 13 of 13.
  • General safety write-ups exist for 13 of 13.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is generally well tolerated short-term but can lower blood pressure and may not be safe for everyone—use only under medical supervision. Common side effects from oral amino acids in this blend may include abdominal pain, bloating, nausea, diarrhea, headache, heartburn, constipation, and insomnia, depending on the dose and individual response.

L-phenylalanine should be avoided by people with phenylketonuria (PKU). L-methionine at high doses may raise homocysteine levels, a risk factor for heart disease.

Most amino acids in this product have not been well studied for long-term safety.

Side effects, ingredient by ingredient L-arginine Alpha-alanine Methionine Tyrosine Phenylalanine Proline Glycine Ornithine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 13 matched ingredients can interact with medications — Lysine, Phenylalanine, L-arginine, Tyrosine, Glycine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 439 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using if you take levodopa (Parkinson disease), NMDA antagonists, blood pressure medications (including ACE inhibitors and ARBs), blood thinners (anticoagulants and antiplatelet drugs), diabetes drugs, thyroid hormones, clozapine (antipsychotic), baclofen (muscle relaxant), MAOIs (antidepressants), sildenafil (Viagra), or 5-HT4 agonists (gut-motility drugs). The most serious risks involve levodopa and NMDA antagonists.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a broad amino acid blend intended to support protein metabolism and general wellness. If you take levodopa (for Parkinson disease), blood pressure medications, blood thinners, diabetes drugs, thyroid hormones, psychiatric medications including clozapine, or NMDA antagonists, you should check your exact medications with our tool before starting.

Talk to your pharmacist or doctor before using, especially if you have PKU, heart disease, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 13 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Acid Complex, straight from the product label.

Brand Wonder Labs
Barcode (UPC) 099528670277
Net contents 270 Tablet(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 260735
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Acid Complex by Wonder Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
270
UPC/BARCODE
099528670277
IngredientAmount% DV
L-Leucine39 mg--
L-Arginine115.5 mg--
L-Alanine126 mg--
L-Isoleucine18 mg--
L-Methionine13.5 mg--
L-Tyrosine9 mg--
L-Phenylalanine24 mg--
L-Valine33 mg--
L-Proline205.5 mg--
L-Glycine349.5 mg--
L-Ornithine Hydrochloride22.5 mg--
L-Aspartic Acid67.5 mg--
L-Histidine13.5 mg--
L-Glutamic Acid150 mg--
L-Threonine28.5 mg--
L-Lysine49.5 mg--
L-Serine51 mg--
Collagen1500 mg--

Other ingredients: Veg. Cellulose, Silica, Veg. Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 tablet twice a day before meals or exercise.

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of the reach of children.

Caution: If you are pregnant or nursing do not take this product.

Phenylketonurics: Contains Phenylalanine.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees - 30 degrees C).

Formulation

Contains no preservatives, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish

Non-GMO Gluten free

Seals/Symbols

FDA Registered Facility Certified GMP Good Manufacturing Practice USA Made

Formula

Free form amino acids

8 Essential amino acids 3 Branch-chain amino acids

FDA Statement of Identity

Dietary Supplement

General Statements

Reorder #6702

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino Acid Complex by Wonder Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino Acid Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino Acid Complex by Wonder Labs

These are the 17 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container270 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Collagen

1500 mg per serving

Other (inactive) ingredients: Veg. Cellulose, Silica, Veg. Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Acid Complex by Wonder Labs Drug Interactions

Want to check YOUR meds against Amino Acid Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
439Drugs
8 Major 423 Moderate 8 Minor

Ingredients driving the most interactions

L-Arginine 403
L-Tyrosine 21
L-Phenylalanine 16
L-Threonine 3
L-Glycine 1

Individual Drug Interactions

The ingredients in Amino Acid Complex interact with 439 drugs. Click any drug to see the details.

6 of the 17 ingredients in Amino Acid Complex interact with drugs. Each result below shows which ingredient is responsible. L-Arginine L-Tyrosine L-Phenylalanine L-Threonine L-Glycine L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Acid Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
L-Glycine full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino Acid Complex, from the product label.

Wonder Labs

See all Wonder Labs products
Name
Wonder Labs
Street Address
115 S.C.T. Court
City
White House
State
TN
ZipCode
37188
Phone Number
800.992.1672
Web Address
www.wonderlabs.com
Pharmacist Counseling Corner

Amino Acid Complex by Wonder Labs: Common Questions

Does Amino Acid Complex by Wonder Labs interact with any medications?
Yes. Based on its ingredients, Amino Acid Complex has a known interaction with 439 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Acid Complex contains 17 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Most amino acids in this blend lack sufficient safety data in pregnancy and lactation. L-methionine, L-histidine, and a few others have some data suggesting they may be okay, but L-phenylalanine, L-ornithine, L-aspartic acid, L-serine, and others are not well studied. Talk with your doctor or pharmacist before using any supplement dose during pregnancy or while breastfeeding—they can weigh your individual situation.
Is this safe for people with PKU (phenylketonuria)?
No. L-phenylalanine, one of the ingredients, should be avoided by anyone with PKU. Check the label carefully and do not use this product if you have PKU.
What side effects might I experience?
Common side effects from these amino acids may include abdominal pain, nausea, diarrhea, bloating, headache, heartburn, constipation, and insomnia. Most are mild and dose-dependent. If you experience persistent or severe symptoms, stop and talk to your pharmacist.
Does this product actually improve muscle growth or athletic performance?
The evidence for most of these amino acids on muscle growth or athletic performance is weak or unclear—the data shows mostly insufficient evidence. L-ornithine is possibly effective for athletic performance, but the overall blend has not been clinically tested for these goals.
Can L-arginine really lower my blood pressure?
Yes, L-arginine can lower blood pressure in some people by increasing nitric oxide, which widens blood vessels. That's why it can interact with blood pressure medications and may cause dangerously low blood pressure if combined with them. Always check with your doctor or pharmacist if you're on any blood pressure medication.
What does each amino acid do?
These are building blocks for protein and support various body functions—for example, L-tyrosine helps with mood and focus, L-lysine is involved in immune function and collagen, and L-glycine supports joint and gut health. However, the evidence for supplement benefits in healthy people is limited for most of them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino Acid Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Acid Complex label
Go deeper

The Full Monographs Behind Amino Acid Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Alpha-alanine

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...

Read the full Alpha-alanine monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Aspartic Acid

Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is heavily marketed for boosting testosterone...

Read the full Aspartic Acid monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Serine

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has been studied for certain neurological condi...

Read the full Serine monograph →
Sources

Sources & How We Checked

Amino Acid Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 135 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
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Alpha-alanine 2 references
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See these in context on the Alpha-alanine monograph →

Methionine 12 references
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Tyrosine 4 references
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Phenylalanine 23 references
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Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
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Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
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  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

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Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Aspartic Acid 1 reference
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI

See these in context on the Aspartic Acid monograph →

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
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  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

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Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
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  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

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Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

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