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Dietary supplement

AminO.D. Jolly Watermelon Ingredients & Drug Interactions

by Purus Labs

AminO.D. Jolly Watermelon label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AminO.D. Jolly Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AminO.D. Jolly Watermelon is a dietary supplement by Purus Labs with 1 active ingredient.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against AminO.D. Jolly Watermelon by Purus Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with AminO.D. Jolly Watermelon by Purus Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of AminO.D. Jolly Watermelon by Purus Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “AminOD EAA Repletion Matrix” is a proprietary blend — the label gives one combined amount (5.80 Gram(s)) without saying how much of each component you get.
  • “AminoBlast” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

AminO.D. Jolly Watermelon is a powder with 7 ingredients, most of them branched-chain and essential amino acids.

The active amino acids are L-Leucine, L-Isoleucine, L-Valine, L-Phenylalanine, L-Histidine, L-Threonine, and L-Lysine. These are building blocks your body uses to build and repair muscle.

The product also contains inactive ingredients — citric acid, natural and artificial flavor, malic acid, sucralose, and silica — that add taste and texture.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle protein synthesis and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle hypertrophy, Post-workout recovery.
  • The closest evidence on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for these individual amino acids is mixed. L-Phenylalanine is possibly effective for vitiligo but possibly ineffective for ADHD, and there isn't enough data to rate it for alcohol use disorder or multiple sclerosis.

L-Lysine is possibly effective for cold sores but lacks solid evidence for wound healing or child growth. L-Histidine has some evidence for cholera but insufficient data for eczema, kidney disease, or rheumatoid arthritis.

L-Threonine appears possibly ineffective for ALS and lacks reliable evidence for MS or spasticity. The effectiveness of L-Valine, L-Leucine, and L-Isoleucine for specific health conditions isn't established in the data we hold.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Phenylalanine is generally well tolerated at typical doses but should not be used by people with PKU (phenylketonuria). Common side effects include anxiety, constipation, headache, heartburn, insomnia, nausea, and sedation.

The safety data advises against supplement doses during pregnancy and while breastfeeding. L-Threonine from food is safe; supplements may cause headache or minor stomach upset including diarrhea, gas, or constipation.

Supplement use in pregnancy and breastfeeding hasn't been well studied. L-Lysine is generally well tolerated, though high amounts may upset your stomach; long-term safety isn't well studied.

There's limited safety data for pregnancy and breastfeeding. L-Histidine and the other amino acids lack established adverse effects in our data, but their safety at supplement doses hasn't been fully studied.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Lysine, Phenylalanine, Threonine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on levodopa (Parkinson medication) — L-Phenylalanine can reduce how well it works. Also check for baclofen (muscle relaxer), MAOIs (older antidepressants), NMDA antagonists (certain neurological drugs), or 5-HT4 agonists (GI medications).

We couldn't verify interactions for L-Leucine, L-Isoleucine, or L-Valine, so use the medication checker on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is an amino acid blend most suited to people looking to support muscle. If you take levodopa, baclofen, an MAOI, or an NMDA antagonist, you need to check with your pharmacist before using it.

Anyone with PKU should avoid L-Phenylalanine. Pregnant or breastfeeding individuals should discuss this product with their doctor or pharmacist first, as safety data is limited for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AminO.D. Jolly Watermelon, straight from the product label.

Brand Purus Labs
Barcode (UPC) 855734002154
Net contents 219 Gram(s); 7.7 oz.
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36800
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AminO.D. Jolly Watermelon by Purus Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.3 Gram(s)
Maximum serving Sizes:
7.3 Gram(s)
Servings per container
30
UPC/BARCODE
855734002154
IngredientAmount% DV
L-Leucine2.1 Gram(s)--
L-Isoleucine480 mg--
L-Phenylalanine839 mg--
L-Valine600 mg--
L-Histidine480 mg--
L-Threonine600 mg--
L-Lysine719 mg--
AminOD EAA Repletion Matrix5.8 Gram(s)--
AminoBlast0 NP--

Other ingredients: Citric Acid, Natural and Artificial flavor, Malic Acid, Sucralose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

SUBSTANTIATED EFFECTS The importance of amino acids, with regards to muscle protein synthesis, has long been accepted and validated; however, which exact amino acids at what specific ratios are the more important questions.

It even outperforms whole protein!

{chart} 36 PERCENT AMINOBLAST(R) L-LEUCINE 14 PERCENT L-PHENYLALANINE 12 PERCENT L-LYSINE 10 PERCENT L-VALINE 10 PERCENT L-THREONINE 8.5 PERCENT L-ISOLEUCINE 8.5 PERCENT L-HISTIDINE

ALL DAY ANABOLISM

ESSENTIAL AMINO ACID REPLETION DRINK PRE - INTRA - POST MPS ENHANCER

30 TRUE SERVINGS

NATURAL & ARTIFICIAL FLAVOR

MORE EFFECTIVE THAN PROTEIN LESS EXPENSIVE THAN PROTEIN LESS CALORIES THAN PROTEIN

NUTRITIONAL INFO

FOLLOW US FACEBOOK.COM/PURUSLABS TWITTER @PURUSLABS INSTAGRAM @PURUSLABS

PROUDLY MADE IN THE U.S.A.

Brand IP Statement(s)

We conducted a meta analysis on over 10 years of ergogenic amino acid research to bring you the most comprehensively anabolic amino acid composition available, AminOD(R), the industry's first muscle protein synthesis-stimulating essential amino acid matrix.

Suggested/Recommended/Usage/Directions

AminOD(R) usage: As research provides evidence for effectively taking a serving of AminOD pre, intra and 1-2 hours post workout, mix one serving in 8 oz. cold water in any of the above instances to maximize muscle protein synthesis. For an anytime flavor splash, mix one serving in your water and enjoy as needed.

SIMPLIFIED USAGE 1 LEVEL SCOOP 8 OZ. WATER OR OTHER DRINK ALL DAY ANY DAY

Precautions

WARNING: AminOD(R) is intended only for healthy adults over the age of 18.

Do not use if you are currently pregnant or nursing, could be pregnant, or are attempting to become pregnant.

Consult a licensed healthcare practitioner before using this product. Discontinue use and contact a doctor immediately if you experience an irregular or rapid heart beat, chest pain, shortness of breath, dizziness, lightheadedness, fainting or presyncope, tremors, headache, nausea, or other similar symptoms. If you are a performance athlete, please check with your sanctioning body prior to use to ensure compliance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT WITH SEVEN ESSENTIAL AMINO ACIDS

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AminO.D. Jolly Watermelon by Purus Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AminO.D. Jolly Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AminO.D. Jolly Watermelon by Purus Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size7.3 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

AminOD EAA Repletion Matrix

5.8 Gram(s) per serving
  • › AminoBlast

Other (inactive) ingredients: Citric Acid, Natural and Artificial flavor, Malic Acid, Sucralose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

AminO.D. Jolly Watermelon by Purus Labs Drug Interactions

Want to check YOUR meds against AminO.D. Jolly Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
8 Major 11 Moderate 1 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in AminO.D. Jolly Watermelon interact with 20 drugs. Click any drug to see the details.

0 of the 1 ingredient in AminO.D. Jolly Watermelon interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in AminO.D. Jolly Watermelon with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for AminO.D. Jolly Watermelon, from the product label.

Purus Labs

See all Purus Labs products
Name
Purus Labs(R)
Street Address
11370 Pagemill Rd.
City
Dallas
State
TX
Web Address
www.puruslabs.net
Pharmacist Counseling Corner

AminO.D. Jolly Watermelon by Purus Labs: Common Questions

Does AminO.D. Jolly Watermelon by Purus Labs interact with any medications?
Yes. Based on its ingredients, AminO.D. Jolly Watermelon has a known interaction with 20 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AminO.D. Jolly Watermelon contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
L-Phenylalanine should not be used at supplement doses during pregnancy or breastfeeding — the safety data advises against it. For L-Threonine and L-Lysine, there isn't enough reliable data to know either way, so you'd need to talk with your doctor or pharmacist for personalized advice. The other ingredients lack pregnancy/breastfeeding data on file with us.
What are the amino acids in this product actually for?
These are branched-chain and essential amino acids — building blocks your body uses to build and repair muscle tissue. Leucine, isoleucine, and valine are particularly important for muscle protein synthesis. Lysine has some evidence for cold sores. The others support general nutrition, though the data on specific health benefits is limited or mixed.
Are there fillers in this powder?
Yes. Besides the seven active amino acids, this product contains citric acid, natural and artificial flavor, malic acid, sucralose, and silica — those are inactive ingredients that add taste and texture to the powder.
I have PKU. Can I take this?
No. This product contains L-Phenylalanine, which people with PKU must avoid. Talk with your doctor about amino acid supplements that are safe for your condition.
What side effects might I experience?
L-Phenylalanine may cause anxiety, constipation, headache, heartburn, insomnia, nausea, or sedation. L-Threonine can cause headache or minor stomach upset like diarrhea, gas, or constipation. L-Lysine may cause abdominal pain, diarrhea, or indigestion, especially at high doses. Most people tolerate these amino acids well at typical amounts.
Does this product have any interactions I should know about?
Yes — there are a few important ones. L-Phenylalanine interacts with levodopa (Parkinson medication), baclofen (muscle relaxer), and MAOIs (certain antidepressants). L-Threonine interacts with NMDA antagonists, and L-Lysine with 5-HT4 agonists. Use the medication checker on this page to verify your exact drugs before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AminO.D. Jolly Watermelon is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AminO.D. Jolly Watermelon label
Sources

Sources & How We Checked

AminO.D. Jolly Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
  7. Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
  8. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  9. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  10. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  11. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  12. Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
  13. Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
  15. Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
  16. Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
  17. Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
  18. Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
  19. Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
  20. Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
  2. Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
  3. Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

See these in context on the Threonine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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