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Niacin, also known as vitamin B3, is a water-soluble vitamin found in a variety of foods, including meat, poultry, fish, and fortified grains. It plays a variety of roles in the body, including in the metabolism of carbohydrates, fats, and proteins. It is also necessary for the production of energy in the body and in the synthesis of different hormones. Niacin deficiency is rare in developed countries, however, supplementation has been shown to have several positive benefits. For example, it can reduce the risk of diabetic neuropathy (i.e., nerve pain) and has been shown effective for treating some types of high cholesterol (extended-release niacin is used as a prescription drug in the United States for this purpose). There is a multitude of niacin forms available as dietary supplements, including NADH, niacinamide, and nicotinamide riboside, all with different properties.

Vitamin B12, also known as cobalamin, is a water-soluble vitamin crucial for several bodily functions. It plays a pivotal role in the formation of red blood cells, aiding in the prevention of anemia. Vitamin B12 is essential for maintaining a healthy nervous system and proper brain function, as it is involved in the synthesis of myelin, the protective sheath around nerve fibers. This vitamin is primarily found in animal-based foods such as meat, fish, dairy products, and eggs, making it important for vegetarians and vegans to consider supplementation. A deficiency in vitamin B12 can lead to neurological issues, fatigue, and cognitive impairment.

L-Threonine is an essential amino acid, meaning it must be obtained through the diet since the body cannot produce it on its own. It plays a crucial role in supporting overall health and well-being. L-Threonine is involved in protein synthesis, aiding in the formation of collagen, elastin, and muscle tissue. It also contributes to maintaining proper immune function and balancing nitrogen levels within the body.

Methionine is an essential amino acid, meaning it must be obtained through the diet since the body cannot produce it on its own. It plays a crucial role in protein synthesis and various metabolic processes. Methionine is commonly found in protein-rich foods like meat, fish, dairy products, and certain plant-based sources, making it an important component of a balanced diet to support overall health and proper bodily functions.