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Dietary supplement

Andrographis Extract 1000 mg Ingredients & Drug Interactions

by Puritan's Pride

Andrographis Extract 1000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Andrographis Extract 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Andrographis Extract 1000 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis Whole Plant Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Andrographis Extract 1000 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Andrographis Extract 1000 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Andrographis Extract 1000 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: andrographis whole plant extract, 1000 mg per tablet. Andrographis is a plant used traditionally and in clinical research for conditions like sore throat, ulcerative colitis, and joint pain.

The tablet also contains several inactive ingredients—calcium carbonate, cellulose, polyethylene glycol, silica, magnesium stearate, and stearic acid—which are fillers and binders that help form and preserve the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Andrographis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Andrographis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Ulcerative colitis — rated "Possibly Effective" (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Natural Medicines).
  • On file: Tonsillopharyngitis — rated "Possibly Effective" (Natural Medicines).

The evidence for andrographis is modest. It's rated possibly effective for sore throat (tonsillopharyngitis), ulcerative colitis, and osteoarthritis based on available research.

For familial Mediterranean fever, the evidence we have is insufficient to rate it one way or the other. If you're considering this product for one of those three conditions, talk with your pharmacist or doctor about whether the research supports its use for your specific situation.

The evidence, ingredient by ingredient Andrographis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andrographis is generally well tolerated when taken short-term, but long-term safety and product quality aren't well established. The most common side effects are abdominal discomfort, altered taste, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, and rash—and these are more likely at higher doses (above 5–10 mg/kg of andrographolide) or if you take it for longer than 14 days.

Rarely, severe allergic reactions including anaphylaxis have been reported. Skin reactions, including Stevens-Johnson syndrome and other serious rashes, have also been documented.

During pregnancy, safety data suggests avoiding andrographis because of theoretical concerns and animal-study findings about reproductive effects. While breastfeeding, there isn't enough safety information, so it's best not to use it.

If you're pregnant or nursing, talk with your doctor or pharmacist before taking any supplement.

Side effects, ingredient by ingredient Andrographis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andrographis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 413 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) or blood pressure medications—andrographis may increase bleeding risk or lower your pressure further. If you take immunosuppressants (after a transplant, for example) or the pain relievers etoricoxib or celecoxib, or the diabetes drug glipizide, run those through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Andrographis may help with sore throat, ulcerative colitis, or joint pain, but the evidence is moderate. It's a serious concern if you take blood thinners, blood pressure medications, or immunosuppressants—check your medications first.

Avoid it if you're pregnant or breastfeeding. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Andrographis Extract 1000 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 074312004803
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286432
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Andrographis Extract 1000 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
074312004803
IngredientAmount% DV
Andrographis Whole Plant Extract1000 mg--

Other ingredients: Calcium Carbonate, Cellulose, Polyethylene Glycol, Silica, Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilitates ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item #21709 www.puritan.com 1-800-645-1030

Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if outer seal is broken or missing.

Contains bioengineered food ingredients.

Storage

Store at room temperature.

Brand IP Statement(s)

Copyright 2021 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formula

Andrographis extract 1000 mg per serving

Formulation

Supports immune system health Standardized extract

No artificial color, flavor or sweetener, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) tablets daily, preferably with meals.

FDA Disclaimer Statement

This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Andrographis Extract 1000 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Andrographis Extract 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Andrographis Extract 1000 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Andrographis Whole Plant Extract

Interacts with
413 drugs
1000 mg per serving Form: Andrographolide

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis Whole Plant Extract monograph & interactions

Other (inactive) ingredients: Calcium Carbonate, Cellulose, Polyethylene Glycol, Silica, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Andrographis Extract 1000 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Andrographis Extract 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
413Drugs
408 Moderate 5 Minor

Ingredients driving the most interactions

Andrographis Whole Plant Extract 413

Individual Drug Interactions

The ingredients in Andrographis Extract 1000 mg interact with 413 drugs. Click any drug to see the details.

1 of the 1 ingredient in Andrographis Extract 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Andrographis Whole Plant Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Andrographis Extract 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Andrographis Whole Plant Extract6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Andrographis Whole Plant Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Andrographis Extract 1000 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Andrographis Extract 1000 mg by Puritan's Pride: Common Questions

Does Andrographis Extract 1000 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Andrographis Extract 1000 mg has a known interaction with 413 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Andrographis Extract 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No. During pregnancy, the safety data advises against it because of theoretical concerns and animal-study findings about reproductive effects. While breastfeeding, there isn't enough safety information to know either way. Talk with your doctor or pharmacist for personalized guidance.
What are the most common side effects?
The most common are stomach discomfort, changed taste, diarrhea, dizziness, tiredness, headache, nausea, vomiting, itching, and rash. These are more likely at higher doses or if you take it for longer than 14 days. Rarely, severe allergic reactions have occurred.
Is it safe to take long-term?
Andrographis is generally well tolerated short-term, but long-term safety isn't well established. The evidence suggests that side effects become more likely at higher doses or beyond 14 days of use.
Does it actually work for sore throat?
The research rates it possibly effective for sore throat (tonsillopharyngitis), along with ulcerative colitis and osteoarthritis. The evidence is modest, so talk with your pharmacist about whether it's a good fit for what you're dealing with.
What's in this tablet besides the active ingredient?
It contains calcium carbonate, cellulose, polyethylene glycol, silica, magnesium stearate, and stearic acid—all inactive ingredients that help form and preserve the tablet.
Can it cause severe allergic reactions?
Severe allergic reactions, including anaphylaxis, are rare but have been reported. Skin reactions including Stevens-Johnson syndrome and other serious rashes have also been documented. Stop and seek medical care if you notice severe symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Andrographis Extract 1000 mg label
Go deeper

The Full Monographs Behind Andrographis Extract 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph →
Sources

Sources & How We Checked

Andrographis Extract 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
  12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
  13. Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
  19. Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
  25. Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
  26. Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed

See these in context on the Andrographis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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