Interactions on record — worth a quick check against your medications. Based on 7 of 12 ingredients. Check your meds →
Dietary supplement

Anotest Fruit Punch Ingredients & Drug Interactions

by MuscleTech Performance Series

Anotest Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Anotest Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Anotest Fruit Punch is a dietary supplement by MuscleTech Performance Series with 12 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 360 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Zinc, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Anotest Fruit Punch by MuscleTech Performance Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Anotest Fruit Punch by MuscleTech Performance Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Anotest Fruit Punch by MuscleTech Performance Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Boron Citrate” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Testosterone-Boosting Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “L-Carnitine Tartrate” is listed as a grouped ingredient — the label gives one combined amount (2,932 mg) without saying how much of each component you get.

Anotest Fruit Punch contains 11 active ingredients. The main amino acids are L-glutamine (important for immune function and gut health), L-leucine, L-isoleucine, and L-valine (branched-chain amino acids that support muscle recovery), plus D-aspartic acid and L-carnitine tartrate (which supplies L-carnitine for energy and fat metabolism).

The product also includes B vitamins—B6, B12, and folic acid—which support energy and nerve function. Zinc and boron support athletic performance and recovery, and boron citrate supplies additional boron.

Two proprietary blends round out the formula: a Testosterone-Boosting Complex and a Cortisol-Lowering and Recovery Complex. The powder also contains inactive ingredients including natural and artificial flavors, sweeteners (sucralose and acesulfame-potassium), FD&C Red No.

40 for color, sodium citrate, and malic acid.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: testosterone boosting for bodybuilders.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Androgen receptor function, Free testosterone elevation, Hormonal optimization.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for this product's ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness.

Vitamin B6 is effective for certain anemias and B6 deficiency itself, and possibly effective for pregnancy-related nausea. Folic acid is effective for folate deficiency and likely effective for preventing neural tube birth defects and treating methotrexate toxicity, with possibly effective use for depression and cognitive issues.

Vitamin B12 is effective for B12 deficiency and cyanide poisoning, and possibly effective for canker sores and postherpetic neuralgia. Zinc is effective for zinc deficiency and likely effective for Wilson disease, with possibly effective use for acne, age-related macular degeneration, and diabetes.

Boron is likely effective for boron deficiency and possibly effective for vaginal candidiasis and radiation dermatitis, though possibly ineffective for athletic performance. L-carnitine is effective for L-carnitine deficiency and possibly effective for heart health and cholesterol.

The specific testosterone-boosting and cortisol-lowering claims made by the proprietary blends cannot be verified from the data we hold.

The evidence, ingredient by ingredient Vitamin B6 Folic Acid Vitamin B12 Zinc Boron L-carnitine Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at recommended doses. L-glutamine is well tolerated orally but should only be used under medical supervision in people with kidney or liver disease; pregnancy and lactation data are limited, so consult your doctor.

Vitamin B6 is safe at normal amounts but high doses over time can damage nerves; pregnancy data show it's likely safe, possibly unsafe, and safe during lactation depending on context. Folic acid is generally safe at recommended doses during pregnancy and lactation.

Vitamin B12 is very safe with no established upper limit and is considered safe in pregnancy and lactation. Zinc is safe at recommended amounts but should be avoided at high doses during pregnancy.

Boron should be avoided in pregnancy and while breastfeeding due to limited safety data. L-carnitine is well tolerated at typical doses but safety during breastfeeding is not well studied.

Common side effects across these ingredients include mild gastrointestinal upset (nausea, diarrhea, abdominal discomfort), headache, and a fishy odor from L-carnitine at higher doses.

Side effects, ingredient by ingredient Vitamin B6 Folic Acid Vitamin B12 Zinc Boron L-carnitine Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Glutamine, Vitamin B12, Vitamin B6, Zinc, Folic Acid, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; Parkinson's medications.
  • For scale: 360 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Major interactions documented: anticonvulsants (phenobarbital, phenytoin, and primidone) are potentially antagonized by glutamine and folic acid, risking worsened seizure control. Moderate interactions to double-check: antihypertensive drugs and amiodarone (with vitamin B6); methotrexate, capecitabine, 5-fluorouracil, and pyrimethamine (with folic acid); quinolone and tetracycline antibiotics, cephalexin, penicillamine, ritonavir, integrase inhibitors, and bictegravir/emtricitabine/tenofovir alafenamide (with zinc); blood thinners like warfarin and acenocoumarol (with L-carnitine); and thyroid hormone (with L-carnitine).

Vitamin B6 at high doses may also reduce phenobarbital and phenytoin levels. Use the medication checker to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Anotest Fruit Punch may appeal to athletes and fitness enthusiasts seeking to support muscle recovery and performance with amino acids and recovery-focused nutrients. However, if you take anticonvulsant medications, blood thinners, antibiotics, thyroid hormone, or cancer drugs, you need to check your specific medications with the tool on this page before starting.

Talk to your pharmacist or doctor first, especially if you have kidney or liver disease or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Anotest Fruit Punch, straight from the product label.

Brand MuscleTech Performance Series
Barcode (UPC) 631656703412
Net contents 0.6 lbs; 284 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18092
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Anotest Fruit Punch by MuscleTech Performance Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
14 Gram(s)
Servings per container
40
UPC/BARCODE
631656703412
IngredientAmount% DV
Calories50 {Calories}, 25 {Calories}--
Total Carbohydrates2 g, 1 g1%, 1%
L-Glutamine2000 mg, 1000 mg--
Sugar0 g, 0 g--
Vitamin B64 mg, 2 mg200%, 100%
Folic Acid400 mcg, 200 mcg100%, 50%
Vitamin B122 mcg, 1 mcg33%, 17%
L-Leucine1800 mg, 900 mg--
L-Isoleucine750 mg, 375 mg--
L-Valine750 mg, 375 mg--
D-Aspartic Acid3120 mg, 1560 mg--
Zinc0 mg, 7.5 mg50%
Boron10 mg, 5 mg--
Boron Citrate200 mg, 100 mg--
Testosterone-Boosting Complex0 NP, 0 NP--
L-Carnitine Tartrate2932 mg, 1466 mg--
Supplying L-carnitine2000 mg, 1000 mg--
Cortisol-Lowering and Recovery Complex0 NP, 0 NP--

Other ingredients: Natural and Artificial flavors, Sucralose, Sodium Citrate, Acesulfame-Potassium, FD&C Red No. 40, Malic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

If you’re serious about performance and results, you need the ALL NEW MuscleTech(R) Performance Series! • NO Proprietary Blends • NO Underdosed Key Ingredients • NO Banned Substances (WADA) • NO Fillers • NO Hype • NO Exceptions Just the Most Powerful Formulas Available

ALL NEW ANOTEST(TM)s the first and only powdered testosterone booster designed to give you the effects of four different products in one formula. In fact, if you were to take this formula as a pill, you would have to take over 15 pills just to match the power of this hardcore anabolic powder. NEW ANOTEST(TM) is truly the most complete testosterone-boosting formula available.

• Increases Overall Testosterone Unlike the majority of other products that underdose D-aspartic acid, ANOTEST(TM) contains the exact 3.12-gram dose shown to increase testosterone by over 40% while staying within the normal healthy range.1

(C)2012.

Formula

The First 4-In-1 Testosterone-Boosting Powder for Bodybuilders

3.12g D-Aspartic Acid 200mg Boron Citrate 2g L-Carnitine 5.3g Glutamine & BCAAs Per 2-scoop max serving

General Statements

• Increases Free (Active) Testosterone The only testosterone powder that delivers a scientifically studied dose of boron, shown to increase free testosterone and decrease estradiol levels within the normal range.2

Amplifies Androgen Receptor Concentration A precise 2000mg dose of L-carnitine is shown to increase the concentration of androgen receptors, which bind to free testosterone. Researchers in this study theorized that it improved the uptake of testosterone into the muscle cell.3 The same 2000mg of L-carnitine is shown to be effective in improving recovery after training in three separate human studies through the reduction of muscle tissue damage.4,5,6 REFERENCES 1 Topo et al., 2009. Reproductive Biology and Endocrinology. 7:120. 2 Naghii et al., 2011. Journal of Trace Elements in Medicine and Biology. 25:54-58. 3 Kraemer et al., 2006. Medicine & Science in Sports & Exercise. 38(7):1288-1296. 4 Kraemer et al., 2003. Journal of Strength & Conditioning Research. 17(3):455-462. 5 Ho et al., 2010. Metabolism. 59(8):1190-1199. 6 Volek et al., 2002. American Journal of Physiology – Endocrinology and Metabolism. 282:E474-E482. 7 Sharp et al., 2010. Journal of Strength & Conditioning Research. 24(4):1125-1130.

NEW PERFORMANCESERIES

NATURAL AND ARTIFICIAL FLAVORS

Serving Size: 1 Scoop (7g)

For lot no. and expiry date: see bottle.

QR Code thenewmuscletech.com Twitter @TeamMuscleTech Facebook.com/MuscleTech

• Reduces Serum Cortisol Delivers a specific 5300mg combination dose of glutamine and BCAAs, shown to decrease serum cortisol (a catabolic hormone that inhibits lean muscle gains).7 • No PCT Required This powerful formula works with the body to naturally increase testosterone within the normal healthy range, thus eliminating the need for post-cycle therapy. • Get More for Your Money Unlike the competition, Performance Series products contain superior key ingredients in clinically dosed amounts that are fully disclosed so you know exactly what you are paying for. • Best-In-Class Flavor Every flavor won in head-to-head third-party taste tests against the leading competitors.

FIRST 4-IN-1 TESTOSTERONE-BOOSTING POWDER INCREASES TESTOSTERONE DECREASES ESTRADIOL REDUCES SERUM CORTISOL AMPLIFIES ANDROGEN RECEPTOR CONCENTRATION Results based on core ingredient testing. See side for study details.

Made in the U.S.A. from domestic and international ingredients.

Not intended to treat low testosterone or sexual dysfunction.

Seals/Symbols

AMERICAN MASTERS OF TASTE GOLD MEDAL SUPERIOR TASTE FORMULATED WITH CLINICALLY DOSED KEY INGREDIENTS

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

PROCESSED IN A FACILITY THAT ALSO PROCESSES MILK, EGGS, SOY, WHEAT AND PEANUT INGREDIENTS.

WARNING: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Discontinue use and consult a medical doctor if you experience unusual symptoms.

Consult a medical doctor before use if you have been treated for or diagnosed with, or have a family history of any medical condition or if you are using any prescription or over-the-counter drug(s), including blood thinners.

Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if packaging has been tampered with.

KEEP OUT OF REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Mix 1 serving (1 scoop) with 4 oz. of cold water in the morning. For full effects, mix 2 scoops with 8 oz. of cold water. Do not exceed 2 scoops in a 24-hour period. Read the entire label before use and follow directions provided.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General

8055US 0312

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Anotest Fruit Punch by MuscleTech Performance Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Anotest Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Anotest Fruit Punch by MuscleTech Performance Series

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 g per serving

Vitamin B6

Interacts with
210 drugs
4 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folic Acid

Interacts with
40 drugs
400 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Vitamin B12

Interacts with
20 drugs
2 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Zinc

Interacts with
67 drugs
0 mg per serving Form: Zinc Gluconate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Testosterone-Boosting Complex

0 NP per serving

Cortisol-Lowering and Recovery Complex

0 NP per serving
  • › L-Glutamine
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Other (inactive) ingredients: Natural and Artificial flavors, Sucralose, Sodium Citrate, Acesulfame-Potassium, FD&C Red No. 40, Malic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Anotest Fruit Punch by MuscleTech Performance Series Drug Interactions

Want to check YOUR meds against Anotest Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
360Drugs
333 Moderate 27 Minor

Ingredients driving the most interactions

Vitamin B6 210
Zinc 67
L-Glutamine 50
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in Anotest Fruit Punch interact with 360 drugs. Click any drug to see the details.

6 of the 12 ingredients in Anotest Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Zinc L-Glutamine Folic Acid Vitamin B12 L-Carnitine Tartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Anotest Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

L-Carnitine Tartrate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine Tartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Anotest Fruit Punch, from the product label.

MuscleTech Performance Series

See all MuscleTech Performance Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Anotest Fruit Punch by MuscleTech Performance Series: Common Questions

Does Anotest Fruit Punch by MuscleTech Performance Series interact with any medications?
Yes. Based on its ingredients, Anotest Fruit Punch has a known interaction with 360 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Anotest Fruit Punch contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
Most ingredients are likely safe during pregnancy at recommended doses—L-glutamine, B6, folic acid, B12, zinc, and boron are all rated likely safe or possibly safe. However, folic acid is possibly unsafe and boron is possibly unsafe in pregnancy, so talk with your doctor before starting. Avoid this product if you take seizure medications, blood thinners, thyroid hormone, or cancer drugs without first checking with your pharmacist.
Can I take this while breastfeeding?
Most ingredients are considered safe or likely safe while breastfeeding at recommended doses—B12, zinc, and boron are all rated safely. However, L-glutamine has limited safety data, L-carnitine safety is not well studied, and boron is rated to avoid while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
Does this actually help with muscle recovery?
L-glutamine is possibly effective for postoperative recovery and critical illness, and the branched-chain amino acids (leucine, isoleucine, valine) and L-carnitine are included to support energy and recovery. However, the specific testosterone-boosting and cortisol-lowering claims from the proprietary blends cannot be verified from the data we hold—ask your pharmacist about those claims.
What's the most common side effect?
Mild gastrointestinal upset—nausea, diarrhea, stomach cramps, and bloating—is the most common side effect reported across these ingredients, especially at higher doses. A fishy body odor has also been reported with L-carnitine. These effects are usually dose-related and tend to be mild.
I take antibiotics. Can I use this product?
It depends on which antibiotic. Zinc in this product can reduce the absorption of quinolone antibiotics, tetracyclines, cephalexin, and penicillamine. Take them at least 2 hours before or 4–6 hours after your zinc dose to minimize this interaction. Use the medication checker on this page with your exact antibiotic name, and talk to your pharmacist.
What's in the proprietary blends?
The product lists three proprietary blends—Testosterone-Boosting Complex, Cortisol-Lowering and Recovery Complex, and L-Carnitine Tartrate—but the individual ingredients within those blends are not specified. Contact the manufacturer directly if you need details about what's inside them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Anotest Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Anotest Fruit Punch label
Go deeper

The Full Monographs Behind Anotest Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Anotest Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 264 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
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  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
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  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
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  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
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See these in context on the Vitamin B6 monograph →

Folic Acid 56 references
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  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
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  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
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  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
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See these in context on the Folic Acid monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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See these in context on the Zinc monograph →

Boron 6 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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