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Dietary supplement

Apple Cider Vinegar 500 mg Ingredients & Drug Interactions

by Natural Factors

Apple Cider Vinegar 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar 500 mg is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Cider Vinegar. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Apple Cider Vinegar 500 mg by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar 500 mg by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar 500 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: apple cider vinegar, a fermented apple product traditionally used in cooking and folk remedies. At 500 mg per capsule, you're getting the vinegar in dried or concentrated form.

The capsule also contains gelatin and magnesium stearate as inactive ingredients — the gelatin is the capsule shell itself, and magnesium stearate is a binder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Apple Cider Vinegar's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promotes blood circulation, digestion, and fat storage reduction.
  • We looked for evidence on: Dyspepsia, Obesity, Hyperlipidemia, metabolic health, circulatory function.
  • The closest evidence on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Obesity.

The evidence isn't established in our data for any of apple cider vinegar's common uses — acne, athletic performance, cognitive function, dental plaque, depression, and eczema all carry ratings of insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the studies so far haven't been strong enough to prove it does.

The evidence, ingredient by ingredient Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In food amounts, apple cider vinegar is generally well tolerated. For short-term medicinal use by mouth, it also seems to be well tolerated.

However, safety data on larger supplement doses is limited, and long-term use in bigger amounts may not be safe. Serious side effects are rare but possible with long-term use: low potassium, high renin levels (which can affect blood pressure and kidney function), and bone loss have been reported.

There's one documented case of someone who drank 250 mL daily for 6 years and developed all three. When applied directly to skin, apple cider vinegar can cause chemical burns and irritation, even from a single application.

Side effects, ingredient by ingredient Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use diuretic drugs (water pills), digoxin (Lanoxin), insulin, or any other diabetes medication — these carry Moderate or Minor interactions involving potassium levels and blood sugar. Talk with your doctor or pharmacist about your specific medications before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Apple cider vinegar as a supplement is most suitable for people who don't take diuretics, digoxin, insulin, or diabetes medications — or for those willing to check with their doctor first. If you have a heart condition, take blood-pressure or diabetes medication, or use a potassium-depleting diuretic, talk with your pharmacist or doctor before starting this product.

The evidence for what it treats isn't established yet, so weigh that against any interaction risks for you personally.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar 500 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958020549
Net contents 360 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220700
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar 500 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
180
UPC/BARCODE
068958020549
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Apple Cider Vinegar1000 mg--

Other ingredients: Gelatin Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass Spec Documentation Lab tested

Purity & Potency Guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 1-2 capsules 3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

Apple Cider Vinegar offers a wide variety of health-promoting benefits. Promotes good blood circulation, helps improve digestion, and helps lower the body’s storage of fat. Optimize your healthy well-being by taking Apple Cider Vinegar in the convenient form of a capsule.

Formulation

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

Digestion & circulation

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Recyclable container and label.

Easy to swallow capsules

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Isura is a trademark of Isura

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar 500 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar 500 mg by Natural Factors

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Apple Cider Vinegar

Interacts with
162 drugs
1000 mg per serving Form: Malus pumila

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar monograph & interactions

Other (inactive) ingredients: Gelatin Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar 500 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
89 Moderate 73 Minor

Ingredients driving the most interactions

Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in Apple Cider Vinegar 500 mg interact with 162 drugs. Click any drug to see the details.

1 of the 1 ingredient in Apple Cider Vinegar 500 mg interact with drugs. Each result below shows which ingredient is responsible. Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar 500 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors
Street Address
14224 167th Avenue SE
City
Monroe
State
WA
ZipCode
98272
Pharmacist Counseling Corner

Apple Cider Vinegar 500 mg by Natural Factors: Common Questions

Does Apple Cider Vinegar 500 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar 500 mg has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does apple cider vinegar actually work for acne, eczema, or the other conditions it's marketed for?
The evidence isn't established in the data we hold for any of those uses — acne, eczema, cognitive function, dental plaque, athletic performance, and depression all lack reliable evidence to prove it works. That doesn't mean it's useless, just that research hasn't confirmed it yet.
Is apple cider vinegar safe to take long-term?
In food amounts, yes — it's generally well tolerated. But there's little safety data on large supplement doses over a long time. In bigger amounts taken for years, serious side effects like low potassium, bone loss, and high renin levels have been reported in rare cases.
What's the risk if I take this with my water pill or diabetes medication?
Apple cider vinegar can lower your potassium level, and if your diuretic already depletes potassium, the risk goes up. With diabetes medications and insulin, combined use could cause your blood sugar to drop too low. Check your exact medications with your doctor or pharmacist before starting.
Can I apply apple cider vinegar to my skin directly?
The safety data shows apple cider vinegar can cause chemical burns and skin irritation when applied topically, even from a single application. There are documented cases of burns and erosion from topical use, so it's not recommended for skin application.
Is apple cider vinegar safe during pregnancy or while breastfeeding?
Safety data on apple cider vinegar supplements during pregnancy and lactation isn't on file in our data. Talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding and considering this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar 500 mg label
Go deeper

The Full Monographs Behind Apple Cider Vinegar 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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