Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor Ingredients & Drug Interactions

by vitafusion

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor label
See full label image
Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar Delicious, Natural Apple Cider Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor is a dietary supplement by vitafusion with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Cider Vinegar, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: vitamin B12 and apple cider vinegar. Vitamin B12 is an essential nutrient your body needs for nerve function, red blood cell formation, and DNA synthesis.

Apple cider vinegar is a fermented product made from apples. The remaining ingredients are inactive — they're there to give the gummy its texture, sweetness, and flavor (sugar, glucose syrup, gelatin, oils, waxes, malic acid, and natural flavor).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy metabolism support with apple cider vinegar.
  • We looked for evidence on: Fatigue, Vitamin B12 deficiency, low energy, metabolic support.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

Vitamin B12 is effective for treating B12 deficiency itself and a rare inherited condition called Imerslund-Grasbeck disease, and it's likely effective for cyanide poisoning. It may also help with canker sores and nerve pain after shingles (postherpetic neuralgia), though the evidence is limited.

For apple cider vinegar, the evidence we hold shows insufficient reliable evidence to rate it for acne, athletic performance, cognitive function, dental plaque, depression, or eczema — meaning the research hasn't established whether it works for these uses.

The evidence, ingredient by ingredient Vitamin B12 Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated; your body simply removes excess amounts in the urine, so there's no established upper limit. It's considered safe during pregnancy and breastfeeding at recommended amounts — in fact, it's needed during both.

Allergic reactions are rare but possible, and case reports mention rash, itching, or skin redness; theoretically, if you have a cobalt allergy, you should be aware. Apple cider vinegar in food amounts is well tolerated, but large medicinal doses or long-term use carry caution.

Serious but rare effects from prolonged, large amounts include low potassium levels, bone loss, and elevated renin (a kidney hormone). When applied to skin undiluted or in high concentration, it can cause chemical burns and irritation.

Side effects, ingredient by ingredient Vitamin B12 Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Apple Cider Vinegar, Vitamin B12.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on diuretic drugs (water pills), digoxin (Lanoxin), insulin, or other antidiabetes medications — apple cider vinegar in this product carries Moderate interactions with the first three and a Minor interaction with antidiabetes drugs. Also mention metformin (Glucophage) for diabetes, as vitamin B12 has a Minor interaction there.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take metformin, any diuretic, digoxin, insulin, or other diabetes medication, check your exact drugs with the tool on this page before starting — the apple cider vinegar in this product interacts with several common ones. Vitamin B12 is very safe and needed in pregnancy and breastfeeding, but this gummy's apple cider vinegar concentration means it's not a casual food product.

Talk to your pharmacist or doctor if you have any heart or kidney concerns, or if you're on blood pressure or diabetes medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar Delicious, Natural Apple Cider Flavor, straight from the product label.

Brand vitafusion
Barcode (UPC) 027917018201
Net contents 24 Gummy(ies)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286318
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy Vitamin(s)
Maximum serving Sizes:
2 Gummy Vitamin(s)
Servings per container
12
UPC/BARCODE
027917018201
IngredientAmount% DV
Calories20 Calorie(s)--
Vitamin B124.8 mcg200%
Added Sugars4 Gram(s)8%
Total Sugars4 Gram(s)--
Total Carbohydrate5 Gram(s)2%
Apple Cider Vinegar500 mcg--

Other ingredients: Sugar, Glucose Syrup, Apple juice concentrate, Gelatin, Water, Blend of oils, Beeswax, Carnauba wax, Malic Acid, Natural flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

vitafusion Apple Cider Vinegar gummy vitamins are apple cider vinegar (ACV) made delicious! These babies are packed with 500 mg of apple cider vinegar per serving, plus B-12 for energy metabolism support. You'll love their tasty apple cider flavor with just the right amount of zing!

Apple Cider Vinegar plus B-12 for energy metabolism support 500 mg ACV per serving

Formulation

No artificial flavors or sweeteners No gluten No high fructose corn syrup No dairy No synthetic FD&C dyes

Colors may darken over time, which does not alter potency.

Gummy vitamins

Seals/Symbols

2022 ChefsBest Excellence Award Made in the USA with US & International Ingredients

Certified Renewable Energy Green-e Made with 100% certified renewable electricity.

General Statements

Award winning taste Growing communities with fruitful planting We believe in holistic wellness and realize it's more than just taking vitamins. That's why we support the Fruit Tree Planting Foundation and together have planted more than 200,000 fruit trees in underserved communities. Join our mission vitafusion.com America's #1 gummy vitamin brand

Questions, comments? Call 1-888-334-5389 M-F 9AM-5PM ET www.vitafusion.com

The ChefsBest Excellence Award is awarded to brands that surpass quality standards established by independent professional chefs. Evaluation funded by Church & Dwight Co., Inc.

Our commitment Discard seal, empty & replace cap Plastic bottle Bottle not recyclable unless label removed Plastic label how2recycle.info

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: tree nuts (coconut).

To ensure quality and potency this product is made with higher dietary ingredient levels than labeled. Do not exceed suggested dosage.

If pregnant, nursing, taking medication, or have a medical condition, consult a doctor before using.

Your need for this product may be met through a balanced diet. Talk to your doctor about your nutritional needs. Product has a tamper evident seal.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: Adults take two (2) gummies daily. Chew thoroughly.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy Vitamin(s) Dosage formGummy Or Jelly Servings per container12 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
4.8 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Apple Cider Vinegar

Interacts with
162 drugs
500 mcg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar monograph & interactions

Other (inactive) ingredients: Sugar, Glucose Syrup, Apple juice concentrate, Gelatin, Water, Blend of oils, Beeswax, Carnauba wax, Malic Acid, Natural flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar Delicious, Natural Apple Cider Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
89 Moderate 73 Minor

Ingredients driving the most interactions

Apple Cider Vinegar 162
Vitamin B12 20

Individual Drug Interactions

The ingredients in Apple Cider Vinegar Delicious, Natural Apple Cider Flavor interact with 162 drugs. Click any drug to see the details.

2 of the 2 ingredients in Apple Cider Vinegar Delicious, Natural Apple Cider Flavor interact with drugs. Each result below shows which ingredient is responsible. Apple Cider Vinegar Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar Delicious, Natural Apple Cider Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar Delicious, Natural Apple Cider Flavor, from the product label.

vitafusion

See all vitafusion products
Name
Church & Dwight Co., Inc.
City
Ewing
State
NJ
ZipCode
08628
Phone Number
1-888-334-5389
Web Address
www.vitafusion.com
Pharmacist Counseling Corner

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion: Common Questions

Does Apple Cider Vinegar Delicious, Natural Apple Cider Flavor by vitafusion interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar Delicious, Natural Apple Cider Flavor has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar Delicious, Natural Apple Cider Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Vitamin B12 is considered likely safe during pregnancy and lactation at recommended amounts — it's actually needed during both. However, there isn't enough safety data on large medicinal or supplement doses of apple cider vinegar during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice before starting, especially if you're considering this as a supplement rather than using it in food.
Can this help with weight loss or digestion?
The facts we have don't include evidence ratings for weight loss or digestion. For apple cider vinegar itself, we hold insufficient reliable evidence for acne, athletic performance, cognitive function, dental plaque, depression, and eczema — so research hasn't clearly established whether it works for those uses either. If you're curious about its role in digestion or metabolism, your pharmacist or doctor can discuss what the broader research suggests.
What are the side effects of vitamin B12?
Vitamin B12 taken by mouth is generally well tolerated. Allergic reactions are rare but possible — they show up as rash, itching, or skin redness. In one case, someone with a cobalt allergy developed contact dermatitis from oral B12. Serious side effects are extremely uncommon.
Is this a lot of apple cider vinegar in one gummy?
The facts don't specify the amount of apple cider vinegar per gummy, so I can't tell you whether it's a typical food serving or a higher medicinal dose. Because the safety data shows caution with larger amounts and long-term use, ask your pharmacist to check the label — they can tell you how much you're getting per serving and whether that matters for your situation.
Can I take this if I'm on diabetes medication?
It depends on which medication. Apple cider vinegar may lower blood sugar on its own, so combining it with insulin or other antidiabetes drugs could push your glucose too low. If you take metformin, vitamin B12 can help offset the B12 deficiency metformin sometimes causes — but you'll still need to check your exact medication with the tool on this page or with your pharmacist to be sure it's safe for you.
Does this have fillers?
Yes. The inactive ingredients include sugar, glucose syrup, gelatin, oils, waxes, malic acid, and natural flavor — those are the fillers and binders that make it a gummy. If you're avoiding any of these, check the label to see if this product works for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar Delicious, Natural Apple Cider Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor label
Go deeper

The Full Monographs Behind Apple Cider Vinegar Delicious, Natural Apple Cider Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar Delicious, Natural Apple Cider Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 41 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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