Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Apple Pectin 500 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Apple Pectin 500 mg label
See full label image
Tablet Or Pill Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Pectin 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Pectin 500 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 23 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apple Pectin 500 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Pectin 500 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Apple Pectin 500 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: apple pectin at 500 mg per dose. Pectin is a soluble fiber extracted from apples that's been studied for cholesterol and blood sugar support.

The tablet also contains inactive ingredients (microcrystalline cellulose, dicalcium phosphate, stearic acid, magnesium stearate, and an aqueous coating) that help form and protect the pill.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: soluble fiber for digestive health.
  • We looked for evidence on: Diarrhea, Gastroesophageal reflux disease (GERD), Hypercholesterolemia, Impaired glucose tolerance (Prediabetes), Irritable bowel syndrome (IBS), Constipation — and 2 related terms.
  • The strongest evidence on file: Pectin is rated "Possibly Effective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Gastroesophageal reflux disease (GERD), Irritable bowel syndrome (IBS), Impaired glucose tolerance (Prediabetes).

Apple pectin shows possibly effective evidence for high cholesterol (hypercholesterolemia) in the data we hold. For blood sugar control and prediabetes, the evidence is insufficient—we don't have enough reliable data to say whether it works.

If you're interested in pectin for cholesterol, talk with your doctor about how it might fit into your overall plan.

The evidence, ingredient by ingredient Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pectin from food and typical supplement amounts is generally well tolerated in most people. The most common side effects are mild: diarrhea, gas, loose stools, and mild cramping.

Allergic reactions are rare but can happen in sensitive individuals, and in one case, a child experienced a severe allergic reaction (anaphylaxis) to a pectin-containing product. Pectin supplements haven't been well studied in pregnancy or while breastfeeding, so check with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pectin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 23 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check whether you take lovastatin (a cholesterol drug), any tetracycline antibiotics, or digoxin (a heart medication). All three have Moderate-severity interactions with pectin.

If you do, your pharmacist can help you time your doses to minimize the risk—usually taking them several hours apart works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Apple pectin may help with cholesterol, but it can interfere with three common medication types: lovastatin, tetracycline antibiotics, and digoxin. If you take any of these, separate the timing and ask your pharmacist.

Otherwise, it's generally well tolerated—just watch for gas or loose stools, and talk to your doctor before using it in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Pectin 500 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536014811
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 35114
Product type Fiber And Other Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Pectin 500 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
766536014811
IngredientAmount% DV
Apple Pectin500 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Aqueous Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

specialty

a natural source of soluble fiber

{tablet} actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

digestive health

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free soy free nut free

Does not contain: Yeast, Wheat, Gluten, Salt, Soy, Dairy, Citrus, Fish, Animal Derivatives, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) tablet up to twice daily, preferably with meals.

Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Storage

STORE IN A COOL, DRY PLACE.

General

Item No. VS-1481 1049504 BO 1

Seals/Symbols

V SUITABLE FOR MOST VEGETARIANS

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Pectin 500 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Pectin 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Pectin 500 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Apple Pectin

Interacts with
23 drugs
500 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Apple Pectin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Aqueous Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Pectin 500 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Apple Pectin 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
23Drugs
23 Moderate

Ingredients driving the most interactions

Apple Pectin 23

Individual Drug Interactions

The ingredients in Apple Pectin 500 mg interact with 23 drugs. Click any drug to see the details.

1 of the 1 ingredient in Apple Pectin 500 mg interact with drugs. Each result below shows which ingredient is responsible. Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Pectin 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Pectin 500 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Apple Pectin 500 mg by The Vitamin Shoppe: Common Questions

Does Apple Pectin 500 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Apple Pectin 500 mg has a known interaction with 23 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Pectin 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this affect my blood pressure medication?
The ingredients in this product have no documented interactions with blood pressure medications in the data we hold. That said, always mention all your supplements when you fill a prescription—your pharmacist can double-check your exact medications.
What side effects should I watch for?
Most people experience nothing. If you do notice something, it's usually mild: diarrhea, gas, loose stools, or mild cramping. Allergic reactions are rare but can happen; stop and call your doctor if you have trouble breathing or swelling.
Is pectin safe during pregnancy?
Food amounts of pectin are fine, but pectin supplements in concentrated form haven't been well studied in pregnancy. Talk with your doctor before starting—they know your situation and can give you personalized advice.
Can I take this while breastfeeding?
Dietary amounts of pectin are likely fine, but supplement safety while nursing hasn't been well studied. Check with your doctor or pharmacist to make sure it's right for you and your baby.
Does this actually lower cholesterol?
The evidence says possibly effective for high cholesterol. That means there's some research behind it, but it's not ironclad. If cholesterol management is your goal, talk with your doctor about whether pectin fits into your overall plan.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Pectin 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Pectin 500 mg label
Go deeper

The Full Monographs Behind Apple Pectin 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Apple Pectin 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team