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Dietary supplement

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium Ingredients & Drug Interactions

by Superior Source

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium is a dietary supplement by Superior Source with 5 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 592 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium, Stevia leaf extract, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source

Ask about any prescription or over-the-counter medication and we check it for interactions with B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 active ingredients: vitamin B6, folic acid, vitamin B12, stevia leaf extract, and selenium. Vitamin B6 helps your body use proteins and supports nerve function.

Folic acid is a B vitamin needed for cell division and DNA, and it's especially important for preventing birth defects during pregnancy. Vitamin B12 supports nerve health, red blood cells, and energy production.

Stevia leaf extract is a natural sweetener that contains no calories. Selenium is a mineral that acts as an antioxidant and supports thyroid and immune function.

The product also contains inactive ingredients: lactose, acacia, and natural flavors.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Folate deficiency — rated "Effective" (Folic Acid) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).

Vitamin B6 is effective for treating sideroblastic anemia and B6 deficiency, and likely effective for high homocysteine levels (hyperhomocysteinemia). It's possibly effective for pregnancy-related nausea and vomiting.

Folic acid is effective for folate deficiency, likely effective for preventing birth defects and reducing methotrexate side effects, and possibly effective for depression and cognitive problems. Vitamin B12 is effective for B12 deficiency and a rare absorption disorder, and likely effective for cyanide poisoning.

For stevia, the evidence we hold on diabetes, high blood pressure, and obesity is insufficient to rate its effectiveness. Selenium is likely effective for selenium deficiency, possibly effective for pre-eclampsia and autoimmune thyroiditis, and appears ineffective for high cholesterol (dyslipidemia).

The evidence, ingredient by ingredient Vitamin B6 Folic Acid Vitamin B12 Stevia Selenium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well-tolerated at doses below 100 mg daily, though high doses over time can damage nerves (sensory neuropathy). Common side effects at normal doses are mild — nausea, headache, heartburn.

Folic acid is generally well-tolerated at recommended doses and is considered safe during pregnancy and breastfeeding to prevent birth defects, though late-pregnancy use has been linked in population studies to increased childhood asthma risk. Vitamin B12 is very safe overall with no established upper limit; excess is removed in urine, and it's safe in pregnancy and breastfeeding.

Stevia is generally recognized as safe at typical food amounts, but whole-leaf extracts and high-dose supplements lack detailed safety data. Selenium is safe within normal dietary amounts, but excess selenium can be toxic, affecting liver, skin, nails, and hair.

All ingredients appear generally well tolerated at the doses in this product, but individual sensitivities vary.

Side effects, ingredient by ingredient Vitamin B6 Folic Acid Vitamin B12 Stevia Selenium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Stevia, Vitamin B12, Vitamin B6, Selenium, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 592 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take blood pressure drugs, seizure medications (phenobarbital, phenytoin, primidone), blood thinners or antiplatelet drugs, amiodarone, cancer treatments (capecitabine, methotrexate, 5-fluorouracil), pyrimethamine for parasitic infections, immunosuppressants, lithium, barbiturates, or metformin. These are the drug types with documented moderate or minor interactions in this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward B-vitamin and mineral supplement for people who want to cover their bases with B6, B12, folate, and selenium. If you take medications for blood pressure, seizures, blood clotting, diabetes, mood, or cancer treatment, run this through the checker with your exact drugs first — there are interactions to watch.

Pregnant or breastfeeding? Talk with your doctor or pharmacist before starting, since some of these ingredients have nuances in pregnancy.

Otherwise, chat with your pharmacist if you're unsure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium, straight from the product label.

Brand Superior Source
Net contents 60 MicroLingual(R) Instant Dissolve Tablet(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 70936
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 MicroLingual(R) Tablet(s)
Maximum serving Sizes:
1 MicroLingual(R) Tablet(s)
Servings per container
60
IngredientAmount% DV
Vitamin B62 mg100%
Folic Acid400 mcg100%
Vitamin B121000 mcg16670%
Stevia leaf extract1 mg--
Selenium200 mcg286%

Other ingredients: Lactose, Acacia, Natural Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Dissolves immediately on contact

No shot

Our proprietary hydrodrying process results in fewer inactive binders and fillers and a higher ratio of nutritional ingredients - hence the small size. They efficiently provide your body with the nutrients you need right now.

"Less is more" Simplicity Purity Efficiency No pills to swallow

Formulation

Preservative free

Seals/Symbols

Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Our instant Dissolve MicroLingual Tablets may be small but they are full potency! Typical tablets and capsules need to be swallowed and are inefficiently absorbed in the digestive system. MicroLingual tablets dissolve immediately under the tongue heading straight into the body.

Directions: As a dietary supplement, dissolve one MicroLingual tablet under the tongue daily. This product may also be swallowed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

B-12/B-6 & Folic Acid Plus Selenium

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium

Suggested/Recommended/Usage/Directions

Place on or under the tongue

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 MicroLingual(R) Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folic Acid

Interacts with
40 drugs
400 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Stevia leaf extract

Interacts with
259 drugs
1 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Selenium

Interacts with
321 drugs
200 mcg per serving Form: Selenomethionine

Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...

Selenium monograph & interactions

Other (inactive) ingredients: Lactose, Acacia, Natural Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source Drug Interactions

Want to check YOUR meds against B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
592Drugs
468 Moderate 124 Minor

Ingredients driving the most interactions

Selenium 321
Stevia leaf extract 259
Vitamin B6 210
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium interact with 592 drugs. Click any drug to see the details.

5 of the 5 ingredients in B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium interact with drugs. Each result below shows which ingredient is responsible. Selenium Stevia leaf extract Vitamin B6 Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Selenium6 drug types · 321 drugs

Anticoagulant/Antiplatelet Drugs

Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.

Likelihood Possible Evidence D
Barbiturates

Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.

Likelihood Possible Evidence D
Contraceptive Drugs

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.

Likelihood Possible Evidence B
Niacin

Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Selenium full monograph & interactions

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium, from the product label.

Superior Source

See all Superior Source products
Name
Continental Vitamin Co. Superior Source
City
Los Angeles
State
CA
ZipCode
90058
Phone Number
(800) 421-6175
Web Address
www.superiorsource1.com
Pharmacist Counseling Corner

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source: Common Questions

Does B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium by Superior Source interact with any medications?
Yes. Based on its ingredients, B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium has a known interaction with 592 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while pregnant?
Vitamin B6 is rated likely safe and possibly unsafe in pregnancy — talk with your doctor. Folic acid is likely safe in pregnancy and is actually recommended at standard prenatal doses to prevent birth defects. Vitamin B12 is likely safe. Stevia and selenium in pregnancy are rated possibly safe or possibly unsafe — there isn't enough data to know for sure. Your provider knows your situation best; check with them before you start.
Can this cause side effects?
Most people tolerate these ingredients well at the doses here. Vitamin B6 may cause nausea, headache, or heartburn. Folic acid at recommended levels is generally gentle, though some people report mild stomach upset. Stevia may cause bloating, headache, or dizziness in a small number of people, usually in the first week. Selenium at normal amounts is well-tolerated. High doses of any of these — especially B6 and selenium — can cause problems, but this product's doses are standard.
What is selenium for?
Selenium is a mineral that acts as an antioxidant in your body, protecting cells from damage. It also supports your thyroid gland and immune system. This product contains it to complement the B vitamins in a single formula.
Why is there stevia in a B-vitamin supplement?
Stevia is a natural, zero-calorie sweetener used here to make the tablet taste better without adding sugar or artificial sweeteners. It doesn't play a therapeutic role — it's there for flavor only.
Is this safe if I take metformin?
Metformin can lower vitamin B12 levels over time, so there's a minor interaction — but that's exactly why people on metformin often take a B12 supplement like this one. It's generally a good pairing. Still, let your pharmacist know you're on metformin so they can monitor your B12 status.
Does folic acid really prevent birth defects?
Yes — folic acid is rated likely effective for preventing neural tube birth defects (serious birth defects of the brain and spine) when taken before and during early pregnancy. That's why it's recommended as part of standard prenatal care. Always take it under your doctor's guidance during pregnancy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium label
Go deeper

The Full Monographs Behind B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Selenium

Interacts with 321 drugs

Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who eat a varied diet get enough, and supple...

Read the full Selenium monograph →
Sources

Sources & How We Checked

B-12 1000 mcg B-6 & Folic Acid 400 mcg Plus Selenium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 164 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
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Folic Acid 56 references
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Stevia 10 references
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Selenium 36 references
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See these in context on the Selenium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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