Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

B12 Strips 2000 mcg Winter Berry Ingredients & Drug Interactions

by Essential Source

B12 Strips 2000 mcg Winter Berry label
See full label image
Other (e.g. Tea Bag) Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B12 Strips 2000 mcg Winter Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B12 Strips 2000 mcg Winter Berry is a dietary supplement by Essential Source with 4 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 230 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Methylcobalamin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against B12 Strips 2000 mcg Winter Berry by Essential Source

Ask about any prescription or over-the-counter medication and we check it for interactions with B12 Strips 2000 mcg Winter Berry by Essential Source — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of B12 Strips 2000 mcg Winter Berry by Essential Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients: biotin, methylcobalamin (a form of vitamin B12), folate, and vitamin B6. Biotin supports nail, hair, and skin health.

Methylcobalamin is the active B12 your body uses for nerve function, energy, and red blood cell formation. We don't have details on what folate does in this formula, but it's a B vitamin your body needs.

Vitamin B6 helps your body metabolize amino acids and supports brain and immune function. The remaining ingredients are inactive excipients — things like hydroxypropyl methyl cellulose, glycerin, stevia, modified starch, natural flavor, gum arabic, sodium carboxymethyl cellulose, monoglyceride stearate, and menthol — that help form and flavor the strip.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Increase energy and promote cardiovascular health.
  • We looked for evidence on: Fatigue, Cardiovascular disease (CVD), Hyperhomocysteinemia, Atherosclerosis, Hypertension, Energy metabolism — and 2 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Likely Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Fatigue.

Biotin is likely effective for biotin deficiency, but the evidence doesn't support its use for multiple sclerosis or seborrheic dermatitis. Methylcobalamin (B12) is effective for B12 deficiency and Imerslund-Grasbeck disease, and likely effective for cyanide poisoning; it may help with canker sores and postherpetic neuralgia, though the evidence is weaker.

Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and likely effective for high homocysteine levels; it may help with pregnancy-related nausea. We don't have effectiveness data on file for folate in this product.

The evidence, ingredient by ingredient Biotin Vitamin B12 Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at high doses, because your body removes excess in the urine; a small number of people taking high-dose biotin have reported mild diarrhea. One rare case report linked very high-dose biotin with a chest inflammation, though it's unclear whether biotin alone caused it.

Methylcobalamin (B12) is very safe with no established upper limit and is needed in pregnancy and breastfeeding at normal amounts. Vitamin B6 is safe at normal dietary amounts, but high doses over time can damage nerves; doses above 1000 mg daily pose the greatest risk, though neuropathy can occur at lower doses too.

The most common side effects from B6 at normal doses are mild — headache, nausea, abdominal pain, or loss of appetite. Safety data isn't on file for folate in this product.

Side effects, ingredient by ingredient Biotin Vitamin B12 Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 230 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these types: antihypertensive drugs (blood pressure medications), amiodarone, phenobarbital, phenytoin, levodopa, and metformin. Vitamin B6 in this strip can interact moderately or moderately with several of these; methylcobalamin has a minor interaction with metformin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a B-complex strip aimed at people with B12 deficiency or general energy support. If you take blood pressure medications, seizure drugs, amiodarone, levodopa, or metformin, check with us or your pharmacist before starting — some of these combinations need watching.

Talk to your doctor or pharmacist about whether this product fits your health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B12 Strips 2000 mcg Winter Berry, straight from the product label.

Brand Essential Source
Barcode (UPC) 736211636119
Net contents 30 Fast Dissolving Strip(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 265614
Product type Vitamin
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B12 Strips 2000 mcg Winter Berry by Essential Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Strip(s)
Maximum serving Sizes:
2 Strip(s)
Servings per container
30
UPC/BARCODE
736211636119
IngredientAmount% DV
Biotin2500 mcg833%
Methylcobalamin2000 mcg33333%
Folate800 mcg200%
Vitamin B65 mg250%

Other ingredients: Hydroxypropyl Methyl Cellulose, Glycerin, Stevia, modified Starch, Natural flavor, Gum Arabic, Sodium Carboxy Methyl Cellulose, Monoglyceride Stearate, Menthol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Advanced delivery system Increase energy Promote cardio health

This Product Contains No: Animal byproduct; Egg; Fish & shellfish; Gluten from wheat, rye, oats, or barley; Milk (including lactose); Peanuts; Tree nuts; and soy.

B12 Deficiency May Cause: Fatigue Depression Poor memory Neurological symptoms High homocystiene levels Poor circulation B12 strips promote jitter free energy plus better sleep!!! B12 not only helps create energy for your body, but it also plays a role in your bodies production of melatonin, your natural sleep hormone. Get a sustained boost of energy in the day and restful sleep at night from just one strip.

Formula

Most active forms of vit. B12, B6, and Folate

Strip B12 Advanced Delivery Oral B12 Sublingual B12 Q. Why should I take B12 Strips instead of a pill or liquid? A. When you take a supplement in a digestible form, any B12 present is absorbed by tiny proteins in the stomach and intestines that bind B12. As a result, only a small percentage of any form of B12 makes it into your bloodstream. B12 Utilization Cyanocobalamin B12 Methylcobalamin B12 Q. Why should I choose Methylcobalamin over Cyanocobalamin B12? A. Methylcobalamin is the most efficient form of B12. Before Cyanocobalamin can be properly utilized by the body, it has to be stripped down in a time consuming, multi-step process. Methylcobalamin is already the most highly reduced form, allowing a high level of benefit. This product was manufactured in a GMP approved facility.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: For best results, allow strip to fully dissolve on tongue, swish fluid throughout entire mouth for 30 seconds making sure to pass fluid under tongue. As a dietary supplement take one to two strips daily as needed.

Precautions

Warning: Do not exceed this amount on a regular basis.

Keep out of reach of children.

Storage

Store at 55 to 78 degrees F in a dry place. Keep out of direct sunlight.

General Statements

Free Product Offer: Send us 3 proofs of purchase (receipts/UPC’s) with $6.95 for shipping and handling, and we will send you a 4th box free! It’s that simple. Please recycle

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to prevent, treat or cure any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B12 Strips 2000 mcg Winter Berry by Essential Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B12 Strips 2000 mcg Winter Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B12 Strips 2000 mcg Winter Berry by Essential Source

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Strip(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
2500 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Methylcobalamin

Interacts with
20 drugs
2000 mcg per serving Form: Vitamin B12

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Methylcobalamin monograph & interactions

Folate

800 mcg per serving Form: 5-MTHF

Vitamin B6

Interacts with
210 drugs
5 mg per serving Form: P5P

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methyl Cellulose, Glycerin, Stevia, Modified Starch, Natural flavor, Gum Arabic, Sodium Carboxy Methyl Cellulose, Monoglyceride Stearate, Menthol. These complete the product’s ingredient list but are not active constituents.

Interaction report

B12 Strips 2000 mcg Winter Berry by Essential Source Drug Interactions

Want to check YOUR meds against B12 Strips 2000 mcg Winter Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
230Drugs
205 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Methylcobalamin 20

Individual Drug Interactions

The ingredients in B12 Strips 2000 mcg Winter Berry interact with 230 drugs. Click any drug to see the details.

2 of the 4 ingredients in B12 Strips 2000 mcg Winter Berry interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Methylcobalamin

Each ingredient & the kinds of drugs it affects

For each ingredient in B12 Strips 2000 mcg Winter Berry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Methylcobalamin1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Methylcobalamin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B12 Strips 2000 mcg Winter Berry, from the product label.

Essential Source

See all Essential Source products
Name
Essential Source, Inc.
Street Address
625 Deer Valley Road Suite 103-152
City
Phoenix
State
AZ
ZipCode
85027
Phone Number
(877) 879-9966
Web Address
www.EssentialSource.net
Pharmacist Counseling Corner

B12 Strips 2000 mcg Winter Berry by Essential Source: Common Questions

Does B12 Strips 2000 mcg Winter Berry by Essential Source interact with any medications?
Yes. Based on its ingredients, B12 Strips 2000 mcg Winter Berry has a known interaction with 230 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B12 Strips 2000 mcg Winter Berry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy or while breastfeeding?
Biotin is likely safe in pregnancy and lactation. Methylcobalamin (B12) is needed in pregnancy and lactation and is considered safe at normal recommended amounts — follow your provider's advice on dosing. Vitamin B6 is likely safe in pregnancy and lactation, though there's one caution about higher doses. We don't have safety data on file for folate. Talk with your doctor or midwife about whether this product is right for you.
Can this help with my hair loss or skin condition?
Biotin is likely effective if you have a biotin deficiency, but the evidence doesn't support using it for hair loss (alopecia areata) or seborrheic dermatitis. If you think you have a deficiency, your doctor can test for it.
What are the common side effects?
At normal doses, biotin and B12 are very well tolerated. Vitamin B6 at standard doses may cause mild headache, nausea, abdominal pain, or loss of appetite in some people. High-dose vitamin B6 over time can damage nerves, but that's not a concern at the doses found in most supplements.
Will this give me energy?
B12 does support energy and metabolism, especially if you're deficient. Vitamin B6 also plays a role in how your body uses food for fuel. The evidence on file shows these B vitamins are effective for deficiency; if you don't have a deficiency, energy benefits aren't established in our data.
How much B12 is in each strip?
Each strip contains 2000 mcg of methylcobalamin (the B12 form). That's well above the daily recommendation and is often used for people with absorption issues or deficiency.
Is this form of B12 better than others?
Methylcobalamin is a form your body can use directly. The data on file shows it's effective for B12 deficiency and related conditions. Whether it's better than other B12 forms isn't something our data addresses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B12 Strips 2000 mcg Winter Berry is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B12 Strips 2000 mcg Winter Berry label
Go deeper

The Full Monographs Behind B12 Strips 2000 mcg Winter Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

B12 Strips 2000 mcg Winter Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
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See these in context on the Vitamin B6 monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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