Balance Ingredients & Drug Interactions
by Plexus
What is this page for?
First and foremost: checking Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Balance is a dietary supplement by Plexus with 4 active ingredients. Its ingredients are commonly taken for general antioxidant support, blood sugar support, cholesterol and heart health.Based on those ingredients, 443 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cinnamon bark extract, Mulberry leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Balance by Plexus
Ask about any prescription or over-the-counter medication and we check it for interactions with Balance by Plexus — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Balance by Plexus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Balance contains 4 active ingredients. Mulberry leaf extract and cinnamon bark extract are the two we have complete data for; both have been studied for their effects on blood sugar and other conditions.
The product also contains White Kidney Bean extract and Common Bean extract, though we don't hold detailed information on those two. The capsules are made with inactive ingredients like rice flour, silica, and a few other fillers and binders.
Does it work?
Not established
The evidence we hold doesn't establish that these ingredients work for any condition. Mulberry leaf extract is rated as having insufficient reliable evidence for diabetes, menopausal symptoms, and mouth sores.
Cinnamon bark extract also carries insufficient evidence for diabetes, high cholesterol, diarrhea, amenorrhea, angina, and common cold. That doesn't mean they don't work—it means the studies available to us haven't proven they do.
How safe is it?
Well-documented data
Mulberry leaf extract from the fruit as food is likely fine, but concentrated supplement doses are less studied; the facts caution to avoid concentrated extracts unless your doctor approves. Cassia cinnamon in food amounts is generally safe, but high-dose supplement forms carry a risk of liver damage over time because of a compound called coumarin they contain.
In trials, cinnamon has been generally well tolerated at supplement doses, though a few people reported rashes or allergic skin reactions. Pregnancy and lactation data for mulberry leaf extract isn't on file, so talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check your exact antidiabetes drugs (like metformin, insulin, or sulfonylureas) before starting—both ingredients may increase low blood sugar risk. If you're on any medication that can harm the liver, flag that with your pharmacist, since cinnamon contains coumarin.
Check midazolam (Versed, a sedative sometimes used for procedures) as well—mulberry may slow how your body clears it.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take diabetes medication, you need to check with your pharmacist before starting Balance—both mulberry and cinnamon may lower blood sugar further. If you take medications that stress your liver, cinnamon is another concern.
This isn't a product you should take without running your medications through the checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Balance, straight from the product label.
| Brand | Plexus |
|---|---|
| Barcode (UPC) | P1-BLNC-X60B |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 317548 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Balance by Plexus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1150 mg | -- |
| White Kidney Bean extract | 0 NP | -- |
| Mulberry leaf extract | 0 NP | -- |
| Cinnamon bark extract | 0 NP | -- |
| Common Bean extract | 0 NP | -- |
Other ingredients: Hypromellose, Rice Flour, Dicalcium Phosphate, Medium Chain Triglyceride powder, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Counter carbs and sugars
More balance. Less guilt. Carbs and sugars hide in almost everything you eat. You could avoid them with a rigid, restrictive diet plan, or you can take a more balanced approach. Balance helps block and balance unwanted carbs and sugars - reducing their effects - so you can enjoy your favorite foods without falling off track.
Gluten free, vegetarian, and non-GMO No artificial colors
Gluten free, vegetarian, and non-GMO
60 day money back guarantee
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Adults take 2 capsules 20-30 minutes before or with your largest meal each day. Use in conjunction with a reduced calorie weight loss diet plan. Individual results will vary.
Precautions
Note: Do not exceed suggested daily serving. Do not use if inner safety seal under the cap is broken or missing. Use only as directed.
Not recommended for use by individuals under 18. Keep out of reach of children.
As with any dietary supplement, consult your physician prior to use if you are pregnant, nursing, have or suspect a medical condition, or are taking medication.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Weight management series
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Balance by Plexus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Balance by Plexus
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › White Kidney Bean extract
- › Mulberry leaf extract
- › Cinnamon bark extract
- › Common Bean extract
Other (inactive) ingredients: Hypromellose, Rice Flour, Dicalcium Phosphate, Medium Chain Triglyceride powder, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Balance by Plexus Drug Interactions
HelloPharmacist Interaction Report
Balance by Plexus contains mulberry leaf extract and cinnamon bark extract, both of which have documented interactions with medications.
The most serious concern is mulberry leaf extract with antidiabetes drugs—it may increase the risk of low blood sugar (hypoglycemia) when taken together, so dose adjustments to your diabetes medication might be needed.
Read the full breakdown — every affected drug type, severity by severity
Cinnamon bark extract also interacts with antidiabetes drugs in the same way, potentially lowering blood sugar further. Additionally, cinnamon contains a compound called coumarin that theoretically could cause additive liver damage if you're taking medications known to harm the liver (hepatotoxic drugs).
We could not check White Kidney Bean extract or Common Bean extract—no interaction data is on file for them.
Altogether, these interactions span 426 individual medications. Use the medication checker below to search for your exact prescriptions before you start this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Balance?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Balance interact with 443 drugs. Click any drug to see the details.
2 of the 4 ingredients in Balance interact with drugs. Each result below shows which ingredient is responsible. Cinnamon bark extract Mulberry leaf extract
Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetohexamideDymelor
How Acetohexamide interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Mulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Acetohexamide interactionCinnamon Bark ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Acetohexamide interactionAdagrasibKrazati
How Adagrasib interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Adagrasib interactionAlbiglutideTanzeum
How Albiglutide interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Bark Extract + Albiglutide interactionMulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Albiglutide interactionAldesleukinProleukin
How Aldesleukin interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Aldesleukin interactionAlectinib HydrochlorideAlecensa
How Alectinib Hydrochloride interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Alectinib Hydrochloride interactionAllopurinolCaplenal, Cosuric, Rimapurinol, Zyloprim, Zyloric
How Allopurinol interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Allopurinol interactionAlogliptinNesina
How Alogliptin interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Mulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Alogliptin interactionCinnamon Bark ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Bark Extract + Alogliptin, Metformin interactionMulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Mulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Alogliptin, Pioglitazone interactionCinnamon Bark ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Bark Extract + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Ambrisentan interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amiodarone interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Amphotericin, Tetracycline interactionAnidulafunginEraxis
How Anidulafungin interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Anidulafungin interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Balance — through 2 ingredients. Tap an ingredient for the detail:
Mulberry Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mulberry Leaf Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCinnamon Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Bark Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprocitentanTryvio
How Aprocitentan interacts with Balance — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Bark ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Bark Extract + Aprocitentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cinnamon bark extract
Antidiabetes Drugs
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.
Hepatotoxic Drugs
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
Mulberry leaf extract
Antidiabetes Drugs
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
One small clinical study shows that black mulberry leaf extract has hypoglycemic effects. This is supported by in vitro research which also suggests that constituents in black mulberry twigs and leaves might have hypoglycemic effects.
Midazolam (Versed)
Theoretically, black mulberry might inhibit the metabolism of midazolam.
In vitro research shows that black mulberry juice can inhibit midazolam 1'-hydroxylation, a reaction that is catalyzed by cytochrome P450 3A4. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Balance, from the product label.
Plexus
See all Plexus products- Name
- Plexus Worldwide
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85258
- Phone Number
- 480-998-3490
- Web Address
- www.plexusworldwide.com
Balance by Plexus: Common Questions
Does Balance by Plexus interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my blood sugar?
Is cinnamon safe to take long-term?
Can I take this if I'm pregnant or nursing?
What are the side effects?
What do the bean extracts do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Balance is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Balance’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Mulberry
Interacts with 87 drugsBlack mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for...
Read the full Black Mulberry monograph → Herb & supplement monographCassia Cinnamon
Interacts with 442 drugsCassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...
Read the full Cassia Cinnamon monograph →Sources & How We Checked
Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Mulberry 5 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. PubMed
- Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. PubMed
- Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silic
- Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.
Cassia Cinnamon 20 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
- De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
- Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
- Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
- Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
- Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
- Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
- Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
- Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
- Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
- Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
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