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Dietary supplement

Beta Glucan (1,3/1,6) Ingredients & Drug Interactions

by Priority One Nutritional Supplements

Capsule Category: Fiber And Other Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Beta Glucan (1,3/1,6) is a dietary supplement by Priority One Nutritional Supplements with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta (1,3/1,6) D-Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Beta (1,3/1,6) D-Glucan, a type of soluble fiber derived from yeast and mushrooms. The capsule also holds silicon dioxide as an inactive ingredient and is made from vegetarian material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Beta-glucans's overall clinical evidence instead.

Strong

Strong clinical evidence supports Beta-glucans for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Natural Medicines).

Beta-glucans show likely effectiveness for two conditions: high cholesterol (dyslipidemia) and coronary heart disease. The evidence supports that this ingredient may help reduce cholesterol levels and support heart health.

The evidence, ingredient by ingredient Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated. However, concentrated supplements like this one lack extensive safety data, so caution is advised — start low and monitor how you feel.

During breastfeeding, there's little research on supplement doses, so talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you're on blood pressure medications (antihypertensives) or immunosuppressant drugs. Beta-glucans may lower blood pressure and could interfere with immune-suppressing therapy — both Moderate-severity concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is worth considering if you're interested in supporting cholesterol and heart health, and you don't take blood pressure medications or immunosuppressants. If you do take either of those types of drugs, check with your doctor or pharmacist first.

Because concentrated supplements lack robust safety data, it's smart to discuss this with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta Glucan (1,3/1,6), straight from the product label.

Brand Priority One Nutritional Supplements
Barcode (UPC) 815354020181
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 235665
Product type Fiber And Other Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
815354020181
IngredientAmount% DV
Beta (1,3/1,6) D-Glucan500 mg--

Other ingredients: Silicon Dioxide, Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Recommendations: Take one (1) capsule daily, preferably with a meal or as directed by your physician.

Storage

Keep container tightly closed, store in a cool, dry place.

Formulation

Contains no preservatives.

Vegetarian formulation

Non-GMO

General Statements

Bisphenol-A (BPA) & Phthalate Free

Priority One Nutritional Supplements Inc since 1988

For professional use only.

Seals/Symbols

GMP Certified

FDA Statement of Identity

A Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Beta (1,3/1,6) D-Glucan

Interacts with
293 drugs
500 mg per serving

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta (1,3/1,6) D-Glucan monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements Drug Interactions

Want to check YOUR meds against Beta Glucan (1,3/1,6)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta Glucan (1,3/1,6) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta (1,3/1,6) D-Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Beta Glucan (1,3/1,6), from the product label.

Priority One Nutritional Supplements

See all Priority One Nutritional Supplements products
Name
Priority One Nutritional Supplements, Inc.
Pharmacist Counseling Corner

Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements: Common Questions

Does Beta Glucan (1,3/1,6) by Priority One Nutritional Supplements interact with any medications?
Yes. Based on its ingredients, Beta Glucan (1,3/1,6) has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta Glucan (1,3/1,6) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does beta-glucan actually lower cholesterol?
Yes — beta-glucans from this type of ingredient show likely effectiveness for high cholesterol and heart disease based on clinical evidence. Results vary by person, and it works best as part of a broader approach to heart health.
What side effects should I watch for?
When taken by mouth, beta-glucans are generally well tolerated and side effects are uncommon. In one trial involving high doses in children, one patient developed temporary liver enzyme elevations within five days of starting, though this is rare.
Is it safe to take this while breastfeeding?
There isn't enough research on supplement doses during breastfeeding to know either way. Talk with your doctor or pharmacist about whether it's right for you right now.
What exactly is beta-glucan?
Beta-glucan is a type of soluble fiber, usually extracted from yeast or mushrooms. It's also found naturally in oats, barley, and other foods, but the amount in this supplement is much more concentrated than you'd get from eating.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Beta Glucan (1,3/1,6) is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta Glucan (1,3/1,6) label
Sources

Sources & How We Checked

Beta Glucan (1,3/1,6)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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