Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Betaine HCl+ Ingredients & Drug Interactions

by Enzyme Science

Betaine HCl+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine HCl+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Betaine HCl+ is a dietary supplement by Enzyme Science with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Betaine HCl+ by Enzyme Science

Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine HCl+ by Enzyme Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Betaine HCl+ by Enzyme Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 3 active ingredients.

Betaine HCl+ contains three active ingredients: protease (a digestive enzyme that breaks down protein), betaine hydrochloride (a compound that increases stomach acid), and Mucosave FG. The first two are meant to support protein digestion; the third's role isn't detailed in our data.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: occasional heartburn and indigestion from low stomach acid.
  • We looked for evidence on: Dyspepsia, Low stomach acid, Hypochlorhydria, Acid reflux.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for betaine hydrochloride isn't established in the data we hold. Our sources rate its use for indigestion, low thyroid function, diarrhea, rheumatoid arthritis, food allergies, and hay fever as having insufficient reliable evidence — meaning there's not enough research to say whether it works.

Protease effectiveness is also not rated in our records.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride may irritate your stomach and isn't safe if you have ulcers, gastritis, or true acid reflux — it could make those worse or slow healing. It might cause heartburn.

Protease is generally well tolerated but can occasionally cause digestive upset or allergic reactions; in rare cases, occupational exposure to airborne proteolytic enzymes has triggered asthma or allergic rhinitis. We don't have enough safety data on Mucosave FG to comment.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take proton pump inhibitors (PPIs), H2-blockers, or antacids — betaine hydrochloride may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is for people looking for digestive enzyme support, but it's not for anyone taking acid-reducing medications or managing ulcers and reflux. If you take PPIs, H2-blockers, or antacids, talk to your pharmacist before adding this — the interactions could weaken your medication.

Check your exact drugs on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine HCl+, straight from the product label.

Brand Enzyme Science
Barcode (UPC) 670480300343
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334816
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine HCl+ by Enzyme Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
670480300343
IngredientAmount% DV
Protease0 NP--
Betaine Hydrochloride1300 mg--
Mucosave FG50 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Rice Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

With HCl and an acid-active vegan protease, plus Mucosave FG. Gentle formula includes an acid-active vegan protease (active at a low pH), plus Mucosave FG, a clinically studied blend of prickly pear and olive leaf extracts shown to protect and soothe the stomach lining and boost digestion.

Protease + Mucosave FG

Formulation

Betaine HCl+ offers betaine hydrochloride for occasional heartburn and indigestion due to low stomach acid.

Do not use if safety seal is broken or missing.

For occasional heartburn and indigestion Soothes discomfort Boosts digestion

Vegan

Gluten-free Contains no: Casein, crustaceans, eggs, fish, gluten, milk, nuts, sesame, shellfish, soy, wheat; artificial colors, fillers or flavors Non-GMO

Suggested/Recommended/Usage/Directions

Recommended Dose: Take 1 capsule 1-2 times daily with meals. More may be taken as recommended by a healthcare practitioner.

Precautions

Consult a physician before use if you are pregnant or nursing, taking medications or have a medical condition.

Storage

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan for protocol Practitioner division of Enzymedica

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Mucosave FG is a registered trademark of BIONAP SRL

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine HCl+ by Enzyme Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine HCl+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine HCl+ by Enzyme Science

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Betaine Hydrochloride

Interacts with
36 drugs
1300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Mucosave FG

50 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Rice Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine HCl+ by Enzyme Science Drug Interactions

Want to check YOUR meds against Betaine HCl+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Betaine HCl+ interact with 36 drugs. Click any drug to see the details.

1 of the 3 ingredients in Betaine HCl+ interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Betaine HCl+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Betaine HCl+, from the product label.

Enzyme Science

See all Enzyme Science products
Name
Enzyme Science
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292
Phone Number
855-281-7246
Web Address
EnzyScience.com
Pharmacist Counseling Corner

Betaine HCl+ by Enzyme Science: Common Questions

Does Betaine HCl+ by Enzyme Science interact with any medications?
Yes. Based on its ingredients, Betaine HCl+ has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Betaine HCl+ contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or an ulcer?
No — betaine hydrochloride in this product increases stomach acid and can irritate ulcers or worsen reflux. It's not safe for those conditions. Talk to your pharmacist if you're considering it.
Is this safe during pregnancy?
The safety data advises against it. Betaine hydrochloride isn't recommended during pregnancy without a doctor's approval, and protease safety hasn't been established either. Talk with your doctor before taking this product.
What's protease, and why is it in here?
Protease is an enzyme that breaks down protein in food. It's included to help your body digest protein more completely, but we don't have strong evidence for how well it works.
Can I take this with my stomach medications?
If you take a PPI, H2-blocker, or antacid, this product may make those drugs less effective. Check the medication checker on this page with your exact prescriptions, and ask your pharmacist before starting.
Will this cause side effects?
Protease is generally well tolerated, but a small number of people may experience digestive upset or allergic reactions. Betaine hydrochloride may cause heartburn or stomach irritation. If you notice problems, stop and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine HCl+ is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine HCl+ label
Go deeper

The Full Monographs Behind Betaine HCl+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Betaine HCl+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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